Andreia Sofia Barros concluded her Ph.D. in Biomedical Sciences at the University of Porto in 2024, under a collaboration with Ferring Pharmaceuticals, and is currently a Junior Postdoctoral Researcher at Instituto de Investigação e Inovação em Saúde (i3S). During her PhD, Sofia worked with smart nanosystems to target Inflammatory Bowel Disease, and with complex in vitro 3D models simulating the in vivo intestinal scenarios to use as drug screens and to study the pathology of some diseases. Over the years, Andreia has collaborated with prominent pharmaceutical partners and engaged in extensive training at leading institutions. Her research interest comprises the areas of biomaterials, tissue engineering, nanotechnology, and target intestinal delivery, resulting in multiple high-impact publications and presentations at international conferences. To date, Andreia Sofia published 9 peer-reviewed papers (first author and co-author), 1 book chapter, and presented her work in national and international meetings and conferences. Her work was recognized through several prizes, including the prestigious 2024 Young Scientist Investigator Trainee Award from the Controlled Release Society (CRS). Andreia is also deeply involved in professional societies like the CRS, where she actively contributes as a Young Scientist representative and participates in peer review and conference organization. Overall, Andreia Sofia is a young member of the scientific world, always engaging in several activities and important roles (PhD students representative, Young Scientists representative, and science ambassador), aiming to fight for good and better science quality.
Selected Publications
Trends in 3D models of inflammatory bowel disease. Biochimica et Biophysica Acta - Molecular Basis of Disease1870(3):, 2024. [Journal: Review] [CI: 4] [IF: 4.2 (*)]
DOI: 10.1016/j.bbadis.2024.167042 SCOPUS: 85184021409
Barros A.S., Pinto S., Viegas J., Martins C., Almeida H., Alves I., Pinho S., Nunes R., Harris A., Sarmento B.
Orally Delivered Stimulus-Sensitive Nanomedicine to Harness Teduglutide Efficacy in Inflammatory Bowel Disease. Small20(45):, 2024. [Journal: Article] [IF: 13 (*)]
DOI: 10.1002/smll.202402502 SCOPUS: 85198399661
Barros A.S., Nunes R.
Tissue-based in vitro and ex vivo models for intestinal permeability studies. Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models:309-346, 2024. [Book: Book Chapter] [CI: 1]
DOI: 10.1016/B978-0-443-15510-9.00027-X SCOPUS: 85189588132
Macedo M.H., Barros A.S., Martínez E., Barrias C.C., Sarmento B.
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes. Journal of Controlled Release341:414-430, 2022. [Journal: Article] [CI: 17] [IF: 10,8]
DOI: 10.1016/j.jconrel.2021.11.048 SCOPUS: 85120638989
Helena Macedo M., Baião A., Pinto S., Barros A.S., Almeida H., Almeida A., das Neves J., Sarmento B.
Mucus-producing 3D cell culture models. Advanced Drug Delivery Reviews178:, 2021. [Journal: Review] [CI: 10] [IF: 17,9]
DOI: 10.1016/j.addr.2021.113993 SCOPUS: 85116606046
Barros A.S., Costa A., Sarmento B.
Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs. Advanced Drug Delivery Reviews170:386-395, 2021. [Journal: Review] [CI: 50] [IF: 17,9]
DOI: 10.1016/j.addr.2020.09.008 SCOPUS: 85091498322
Nunes A.S., Barros A.S., Costa E.C., Moreira A.F., Correia I.J.
3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs. Biotechnology and Bioengineering116(1):206-226, 2019. [Journal: Review] [CI: 491] [IF: 4]
DOI: 10.1002/bit.26845 SCOPUS: 85055542622
Nunes A.S., Costa E.C., Barros A.S., de Melo-Diogo D., Correia I.J.
Establishment of 2D Cell Cultures Derived From 3D MCF-7 Spheroids Displaying a Doxorubicin Resistant Profile. Biotechnology Journal14(4):, 2019. [Journal: Article] [CI: 23] [IF: 3,9]
DOI: 10.1002/biot.201800268 SCOPUS: 85054726204
Barros A.S., Costa E.C., Nunes A.S., de Melo-Diogo D., Correia I.J.
Comparative study of the therapeutic effect of Doxorubicin and Resveratrol combination on 2D and 3D (spheroids) cell culture models. International Journal of Pharmaceutics551(1-2):76-83, 2018. [Journal: Article] [CI: 50] [IF: 4,2]
DOI: 10.1016/j.ijpharm.2018.09.016 SCOPUS: 85053219760