S. Silva is a microbiologist with an MSc in Molecular Biology and Genetics from the Faculdade de Ciências Universidade de Lisboa (2008). As an undergraduate she conducted research work at Instituto Nacional de Saúde Dr. Ricardo Jorge (Portugal) with Dra. Mafalda Bourbon and Prof. Anne Soutar at the MRC-CSC Imperial College London (UK).
In 2008 she participated in the internship program InoVContacto, run by the Portuguese Government to work as an R&D scientist in a biotech company in Denmark.
She obtained her PhD degree at the University of Copenhagen (Denmark) in 2014, under the supervision of Prof. Michael Lisby, studying DNA repair and genomic instability, particularly the effect of SUMOylation in the spatiotemporal regulation of DNA double-strand break (DSB) repair and telomere maintenance.
In 2016 she moved to Seville (Spain) to join Prof. Andrés Aguilera at CABIMER for her postdoctoral studies and worked on the role of R-loops and transcription-replication conflicts in genomic instability and their implication in DNA damage response. During her scientific career as a molecular and cell biologist, she has secured several competitive contracts and awards, produced high quality results and published several impacting articles in the field of DNA damage and genomic instability as first and co-author.
In 2022 she retured to Portugal and joined Prof. Helder Maiato’s lab at i3S, where she continues to develop her research in the molecular mechanisms associated with chromosomal and genomic instability in cancer, with a particular focus on breast cancer and translational research.
Selected Publications
Double-checking chromosome segregation. Journal of Cell Biology222(5):, 2023. [Journal: Review] [CI: 14] [IF: 7.4]
DOI: 10.1083/jcb.202301106 SCOPUS: 85151808312
Marchena-Cruz E., Camino L.P., Bhandari J., Silva S., Marqueta-Gracia J.J., Amdeen S.A., Guillén-Mendoza C., García-Rubio M.L., Calderón-Montaño J.M., Xue X., Luna R., Aguilera A.
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops. Cell Reports42(3):, 2023. [Journal: Article] [CI: 15] [IF: 8,8 (*)]
DOI: 10.1016/j.celrep.2023.112148 SCOPUS: 85149861082
Silva S., Guillén-Mendoza C., Aguilera A.
RNase H1 Hybrid-Binding Domain-Based Tools for Cellular Biology Studies of DNA–RNA Hybrids in Mammalian Cells. Methods in Molecular Biology2528:115-125, 2022. [Book Series: Book Chapter] [CI: 5]
DOI: 10.1007/978-1-0716-2477-7_8 SCOPUS: 85132940373
Sessa G., Gómez-González B., Silva S., Pérez-Calero C., Beaurepere R., Barroso S., Martineau S., Martin C., Ehlén Å., Martínez J.S., Lombard B., Loew D., Vagner S., Aguilera A., Carreira A.
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡. EMBO Journal40(7):, 2021. [Journal: Article] [CI: 69] [IF: 14]
DOI: 10.15252/embj.2020106018 SCOPUS: 85101725757
Jimeno S., Prados-Carvajal R., Fernández-Ávila M.J., Silva S., Silvestris D.A., Endara-Coll M., Rodríguez-Real G., Domingo-Prim J., Mejías-Navarro F., Romero-Franco A., Jimeno-González S., Barroso S., Cesarini V., Aguilera A., Gallo A., Visa N., Huertas P.
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair. Nature Communications12(1):, 2021. [Journal: Article] [CI: 39] [IF: 17,7]
DOI: 10.1038/s41467-021-25790-2 SCOPUS: 85115423691
Silva S., Camino L.P., Aguilera A.
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability. Proceedings of the National Academy of Sciences of the United States of America115(43):11024-11029, 2018. [Journal: Article] [CI: 65] [IF: 9,6]
DOI: 10.1073/pnas.1807258115 SCOPUS: 85055538362
Churikov D., Charifi F., Eckert-Boulet N., Silva S., Simon M., Lisby M., Géli V.
SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination. Cell Reports15(6):1242-1253, 2016. [Journal: Article] [CI: 66] [IF: 8,3]
DOI: 10.1016/j.celrep.2016.04.008 SCOPUS: 84964650731
Silva S., Altmannova V., Luke-Glaser S., Henriksen P., Gallina I., Yang X., Choudhary C., Luke B., Krejci L., Lisby M.
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes and Development30(6):700-717, 2016. [Journal: Article] [CI: 22] [IF: 9,4]
DOI: 10.1101/gad.276204.115 SCOPUS: 84961193953
Gallina I., Colding C., Henriksen P., Beli P., Nakamura K., Offman J., Mathiasen D.P., Silva S., Hoffmann E., Groth A., Choudhary C., Lisby M.
Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Nature Communications6:, 2015. [Journal: Article] [CI: 72] [IF: 11,3]
DOI: 10.1038/ncomms7533 SCOPUS: 84926302528
Silva S., Alves A.C., Patel D., Malhó R., Soutar A.K., Bourbon M.
In vitro functional characterization of missense mutations in the LDLR gene. Atherosclerosis225(1):128-134, 2012. [Journal: Article] [CI: 21] [IF: 3,7]
DOI: 10.1016/j.atherosclerosis.2012.08.017 SCOPUS: 84867851336