Where Ideas Grow
Miguel Alves-Ferreira
Team Member

I received my Bachelor degree in Biology from the Faculdade de Ciências da Universidade do Porto (FCUP). I pursued my Master's studies at Faculdade de Ciências e Tecnologia in Universidade de Coimbra in Molecular and Cellular Biology, with a major in Neurobiology. I obtained a PhD degree in Biomedical Sciences (ICBAS; IBMC-i3S, UP) with the thesis entitled “Phenotypic variability in Familial Amyloid Polyneuropathy: TTR modifiers in Caenorhabditis elegans and Human models” in collaboration with the The Scripps Research Institute (TSRI, California). Currently a Junior Research at i3S-UP, I am interested in understanding primary headaches using a multi-omics approach.

Selected Publications

Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Sousa A., Lemos C.,
Large normal alleles of ATXN2 decrease age at onset in transthyretin familial amyloid polyneuropathy Val30Met patients. Annals of Neurology85(2):251-258, 2019. [Journal: Article] [CI: 11] [IF: 9]
DOI: 10.1002/ana.25409 SCOPUS: 85060767805.


Butler V.J., Salazar D.A., Soriano-Castell D., Alves-Ferreira M., Dennissen F.J.A., Vohra M., Oses-Prieto J.A., Li K.H., Wang A.L., Jing B., Li B., Groisman A., Gutierrez E., Mooney S., Burlingame A.L., Ashrafi K., Mandelkow E.M., Encalada S.E., Kao A.W.,
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Human Molecular Genetics28(9):1498-1514, 2019. [Journal: Article] [CI: 19] [IF: 5,1]
DOI: 10.1093/hmg/ddy442 SCOPUS: 85064925578.


Alves-Ferreira M., Coelho T., Santos D., Sequeiros J., Alonso I., Sousa A., Lemos C.,
A Trans-acting Factor May Modify Age at Onset in Familial Amyloid Polyneuropathy ATTRV30M in Portugal. Molecular Neurobiology55(5):3676-3683, 2018. [Journal: Article] [CI: 19] [IF: 4,6]
DOI: 10.1007/s12035-017-0593-4 SCOPUS: 85019539928.


Madhivanan K., Greiner E.R., Alves-Ferreira M., Soriano-Castell D., Rouzbeh N., Aguirre C.A., Paulsson J.F., Chapman J., Jiang X., Ooi F.K., Lemos C., Dillin A., Prahlad V., Kelly J.W., Encalada S.E.,
Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America115(33):E7710-E7719, 2018. [Journal: Article] [CI: 23] [IF: 9,6]
DOI: 10.1073/pnas.1801117115 SCOPUS: 85052735254.


Lemos C., Coelho T., Alves-Ferreira M., Martins-Da-Silva A., Sequeiros J., Mendonça D., Sousa A.,
Overcoming artefact: Anticipation in 284 Portuguese kindreds with familial amyloid polyneuropathy (FAP) ATTRV30M. Journal of Neurology Neurosurgery and Psychiatry85(3):326-330, 2014. [Journal: Article] [CI: 58] [IF: 6,8]
DOI: 10.1136/jnnp-2013-305383 SCOPUS: 84896709791.


Alves-Ferreira M., Pinho T., Sousa A., Sequeiros J., Lemos C., Alonso I.,
Identification of genetic risk factors for maxillary lateral incisor agenesis. Journal of Dental Research93(5):452-458, 2014. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.1177/0022034514523986 SCOPUS: 84898950873.


Dias A., Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Alonso I., Sousa A., Lemos C.,
C1QA and C1QC modify age-at-onset in familial amyloid polyneuropathy patients. Annals of Clinical and Translational Neurology6(4):748-754, 2019. [Journal: Article] [CI: 10] [IF: 3,7]
DOI: 10.1002/acn3.748 SCOPUS: 85062767210.


Santos D., Santos M.J., Alves-Ferreira M., Coelho T., Sequeiros J., Alonso I., Oliveira P., Sousa A., Lemos C., Grazina M.,
MtDNA copy number associated with age of onset in familial amyloid polyneuropathy. Journal of Neurology Neurosurgery and Psychiatry89(3):300-304, 2018. [Journal: Article] [CI: 18] [IF: 8,3]
DOI: 10.1136/jnnp-2017-316657 SCOPUS: 85042883375.


Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Lemos C., Sousa A.,
Familial amyloid polyneuropathy in Portugal: New genes modulating age-at-onset. Annals of Clinical and Translational Neurology4(2):98-105, 2017. [Journal: Article] [CI: 9] [IF: 4,6]
DOI: 10.1002/acn3.380 SCOPUS: 85026195015.


Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Lemos C., Sousa A.,
Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M). European Journal of Human Genetics24(5):756-760, 2016. [Journal: Article] [CI: 36] [IF: 4,3]
DOI: 10.1038/ejhg.2015.180 SCOPUS: 84939553337.


Paneque M., Costa C., Lemos C., Alves-Ferreira M., Sequeiros J., Lemos M.S.,
Proposal of a portuguese tool for quality assessment of genetic counselling: A new tool for healthcare professionals. Acta Medica Portuguesa31(6):321-328, 2018. [Journal: Article] [CI: 3] [IF: ,6]
DOI: 10.20344/amp.9997 SCOPUS: 85049525440.