Miguel Alves-Ferreira
The Center for Predictive and Preventive Genetics
Team Member
I received my Bachelor degree in Biology from the Faculdade de Ciências da Universidade do Porto (FCUP). I pursued my Master's studies at Faculdade de Ciências e Tecnologia in Universidade de Coimbra in Molecular and Cellular Biology, with a major in Neurobiology. I obtained a PhD degree in Biomedical Sciences (ICBAS; IBMC-i3S, UP) with the thesis entitled “Phenotypic variability in Familial Amyloid Polyneuropathy: TTR modifiers in Caenorhabditis elegans and Human models” in collaboration with the The Scripps Research Institute (TSRI, California). Currently a Junior Research at i3S-UP, I am interested in understanding primary headaches using a multi-omics approach.
Selected Publications
Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Sousa A., Lemos C.
Large normal alleles of ATXN2 decrease age at onset in transthyretin familial amyloid polyneuropathy Val30Met patients. Annals of Neurology85(2):251-258, 2019. [Journal: Article] [CI: 13] [IF: 9]
DOI: 10.1002/ana.25409 SCOPUS: 85060767805
Butler V.J., Salazar D.A., Soriano-Castell D., Alves-Ferreira M., Dennissen F.J.A., Vohra M., Oses-Prieto J.A., Li K.H., Wang A.L., Jing B., Li B., Groisman A., Gutierrez E., Mooney S., Burlingame A.L., Ashrafi K., Mandelkow E.M., Encalada S.E., Kao A.W.
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Human Molecular Genetics28(9):1498-1514, 2019. [Journal: Article] [CI: 21] [IF: 5,1]
DOI: 10.1093/hmg/ddy442 SCOPUS: 85064925578
Alves-Ferreira M., Coelho T., Santos D., Sequeiros J., Alonso I., Sousa A., Lemos C.
A Trans-acting Factor May Modify Age at Onset in Familial Amyloid Polyneuropathy ATTRV30M in Portugal. Molecular Neurobiology55(5):3676-3683, 2018. [Journal: Article] [CI: 22] [IF: 4,6]
DOI: 10.1007/s12035-017-0593-4 SCOPUS: 85019539928
Madhivanan K., Greiner E.R., Alves-Ferreira M., Soriano-Castell D., Rouzbeh N., Aguirre C.A., Paulsson J.F., Chapman J., Jiang X., Ooi F.K., Lemos C., Dillin A., Prahlad V., Kelly J.W., Encalada S.E.
Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America115(33):E7710-E7719, 2018. [Journal: Article] [CI: 25] [IF: 9,6]
DOI: 10.1073/pnas.1801117115 SCOPUS: 85052735254
Lemos C., Coelho T., Alves-Ferreira M., Martins-Da-Silva A., Sequeiros J., Mendonça D., Sousa A.
Overcoming artefact: Anticipation in 284 Portuguese kindreds with familial amyloid polyneuropathy (FAP) ATTRV30M. Journal of Neurology Neurosurgery and Psychiatry85(3):326-330, 2014. [Journal: Article] [CI: 66] [IF: 6,8]
DOI: 10.1136/jnnp-2013-305383 SCOPUS: 84896709791
Alves-Ferreira M., Pinho T., Sousa A., Sequeiros J., Lemos C., Alonso I.
Identification of genetic risk factors for maxillary lateral incisor agenesis. Journal of Dental Research93(5):452-458, 2014. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.1177/0022034514523986 SCOPUS: 84898950873
Dias A., Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Alonso I., Sousa A., Lemos C.
C1QA and C1QC modify age-at-onset in familial amyloid polyneuropathy patients. Annals of Clinical and Translational Neurology6(4):748-754, 2019. [Journal: Article] [CI: 12] [IF: 3,7]
DOI: 10.1002/acn3.748 SCOPUS: 85062767210
Santos D., Santos M.J., Alves-Ferreira M., Coelho T., Sequeiros J., Alonso I., Oliveira P., Sousa A., Lemos C., Grazina M.
MtDNA copy number associated with age of onset in familial amyloid polyneuropathy. Journal of Neurology Neurosurgery and Psychiatry89(3):300-304, 2018. [Journal: Article] [CI: 20] [IF: 8,3]
DOI: 10.1136/jnnp-2017-316657 SCOPUS: 85042883375
Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Lemos C., Sousa A.
Familial amyloid polyneuropathy in Portugal: New genes modulating age-at-onset. Annals of Clinical and Translational Neurology4(2):98-105, 2017. [Journal: Article] [CI: 10] [IF: 4,6]
DOI: 10.1002/acn3.380 SCOPUS: 85026195015
Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Lemos C., Sousa A.
Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M). European Journal of Human Genetics24(5):756-760, 2016. [Journal: Article] [CI: 38] [IF: 4,3]
DOI: 10.1038/ejhg.2015.180 SCOPUS: 84939553337
Paneque M., Costa C., Lemos C., Alves-Ferreira M., Sequeiros J., Lemos M.S.
Proposal of a portuguese tool for quality assessment of genetic counselling: A new tool for healthcare professionals. Acta Medica Portuguesa31(6):321-328, 2018. [Journal: Article] [CI: 4] [IF: ,6]
DOI: 10.20344/amp.9997 SCOPUS: 85049525440
Large normal alleles of ATXN2 decrease age at onset in transthyretin familial amyloid polyneuropathy Val30Met patients. Annals of Neurology85(2):251-258, 2019. [Journal: Article] [CI: 13] [IF: 9]
DOI: 10.1002/ana.25409 SCOPUS: 85060767805
Butler V.J., Salazar D.A., Soriano-Castell D., Alves-Ferreira M., Dennissen F.J.A., Vohra M., Oses-Prieto J.A., Li K.H., Wang A.L., Jing B., Li B., Groisman A., Gutierrez E., Mooney S., Burlingame A.L., Ashrafi K., Mandelkow E.M., Encalada S.E., Kao A.W.
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Human Molecular Genetics28(9):1498-1514, 2019. [Journal: Article] [CI: 21] [IF: 5,1]
DOI: 10.1093/hmg/ddy442 SCOPUS: 85064925578
Alves-Ferreira M., Coelho T., Santos D., Sequeiros J., Alonso I., Sousa A., Lemos C.
A Trans-acting Factor May Modify Age at Onset in Familial Amyloid Polyneuropathy ATTRV30M in Portugal. Molecular Neurobiology55(5):3676-3683, 2018. [Journal: Article] [CI: 22] [IF: 4,6]
DOI: 10.1007/s12035-017-0593-4 SCOPUS: 85019539928
Madhivanan K., Greiner E.R., Alves-Ferreira M., Soriano-Castell D., Rouzbeh N., Aguirre C.A., Paulsson J.F., Chapman J., Jiang X., Ooi F.K., Lemos C., Dillin A., Prahlad V., Kelly J.W., Encalada S.E.
Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America115(33):E7710-E7719, 2018. [Journal: Article] [CI: 25] [IF: 9,6]
DOI: 10.1073/pnas.1801117115 SCOPUS: 85052735254
Lemos C., Coelho T., Alves-Ferreira M., Martins-Da-Silva A., Sequeiros J., Mendonça D., Sousa A.
Overcoming artefact: Anticipation in 284 Portuguese kindreds with familial amyloid polyneuropathy (FAP) ATTRV30M. Journal of Neurology Neurosurgery and Psychiatry85(3):326-330, 2014. [Journal: Article] [CI: 66] [IF: 6,8]
DOI: 10.1136/jnnp-2013-305383 SCOPUS: 84896709791
Alves-Ferreira M., Pinho T., Sousa A., Sequeiros J., Lemos C., Alonso I.
Identification of genetic risk factors for maxillary lateral incisor agenesis. Journal of Dental Research93(5):452-458, 2014. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.1177/0022034514523986 SCOPUS: 84898950873
Dias A., Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Alonso I., Sousa A., Lemos C.
C1QA and C1QC modify age-at-onset in familial amyloid polyneuropathy patients. Annals of Clinical and Translational Neurology6(4):748-754, 2019. [Journal: Article] [CI: 12] [IF: 3,7]
DOI: 10.1002/acn3.748 SCOPUS: 85062767210
Santos D., Santos M.J., Alves-Ferreira M., Coelho T., Sequeiros J., Alonso I., Oliveira P., Sousa A., Lemos C., Grazina M.
MtDNA copy number associated with age of onset in familial amyloid polyneuropathy. Journal of Neurology Neurosurgery and Psychiatry89(3):300-304, 2018. [Journal: Article] [CI: 20] [IF: 8,3]
DOI: 10.1136/jnnp-2017-316657 SCOPUS: 85042883375
Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Lemos C., Sousa A.
Familial amyloid polyneuropathy in Portugal: New genes modulating age-at-onset. Annals of Clinical and Translational Neurology4(2):98-105, 2017. [Journal: Article] [CI: 10] [IF: 4,6]
DOI: 10.1002/acn3.380 SCOPUS: 85026195015
Santos D., Coelho T., Alves-Ferreira M., Sequeiros J., Mendonça D., Alonso I., Lemos C., Sousa A.
Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M). European Journal of Human Genetics24(5):756-760, 2016. [Journal: Article] [CI: 38] [IF: 4,3]
DOI: 10.1038/ejhg.2015.180 SCOPUS: 84939553337
Paneque M., Costa C., Lemos C., Alves-Ferreira M., Sequeiros J., Lemos M.S.
Proposal of a portuguese tool for quality assessment of genetic counselling: A new tool for healthcare professionals. Acta Medica Portuguesa31(6):321-328, 2018. [Journal: Article] [CI: 4] [IF: ,6]
DOI: 10.20344/amp.9997 SCOPUS: 85049525440