João Morais Cabral
Neurobiology & Neurologic Disorders
Neurobiology & Neurologic Disorders Program vice-Coordinator
Undergraduate degree in Biochemistry from University of Porto, followed by a research assistant position at the University´s Chemistry department. From 1988 to 1993 I did my PhD at the University of Edinburgh in Scotland after which I went for a postdoc with Robert Liddington, first at the Dana-Farber Cancer Institute/Harvard University in Boston and then at the University of Leicester in the UK. From 1997 to 2000 I did a second postdoc with Roderick MacKinnon at Rockefeller University in New York. I then joined the faculty of the MBB department at Yale University as Assistant professor. In 2007 I was promoted to Associate professor. In 2008 I moved to the IBMC as a Principal Investigator.
Selected Publications
Cereija T.B., Guerra J.P.L., Jorge J.M.P., Morais-Cabral J.H.
c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter. Proceedings of the National Academy of Sciences of the United States of America118(14):, 2021. [Journal: Article] [CI: 22] [IF: 12,8]
DOI: 10.1073/pnas.2020653118 SCOPUS: 85103744229
Harley C.A., Bernardo-Seisdedos G., Stevens-Sostre W.A., Jones D.K., Azevedo M.M., Sampaio P., Lorga-Gomes M., Trudeau M.C., Millet O., Robertson G.A., Morais-Cabral J.H.
Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating. Proceedings of the National Academy of Sciences of the United States of America118(44):, 2021. [Journal: Article] [CI: 5] [IF: 12,8]
DOI: 10.1073/pnas.2108796118 SCOPUS: 85119299559
Teixeira-Duarte C.M., Fonseca F., Morais-Cabral J.H.
Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site. eLife8:, 2019. [Journal: Article] [CI: 10] [IF: 7,1]
DOI: 10.7554/eLife.50661 SCOPUS: 85077594921
Castro-Rodrigues A.F., Zhao Y., Fonseca F., Gabant G., Cadene M., Robertson G.A., Morais-Cabral J.H.
The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase. Journal of Molecular Biology430(24):5029-5049, 2018. [Journal: Article] [CI: 5] [IF: 5,1]
DOI: 10.1016/j.jmb.2018.10.015 SCOPUS: 85056216681
Szollosi A., Vieira-Pires R., Teixeira-Duarte C., Rocha R., Morais-Cabral J.
Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter. PLoS Biology14(1):, 2016. [Journal: Article] [CI: 21] [IF: 9,8]
DOI: 10.1371/journal.pbio.1002356 SCOPUS: 84961353773
Marques-Carvalho M.J., Oppermann J., Muñoz E., Fernandes A.S., Gabant G., Cadene M., Heinemann S.H., Schönherr R., Morais-Cabral J.H.
Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel. Structure24(10):1742-1754, 2016. [Journal: Article] [CI: 10] [IF: 4,9]
DOI: 10.1016/j.str.2016.07.020 SCOPUS: 84989908805
Harley C., Starek G., Jones D., Fernandes A., Robertson G., Morais-Cabral J.
Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain. Proceedings of the National Academy of Sciences of the United States of America113(35):9916-9921, 2016. [Journal: Article] [CI: 16] [IF: 9,7]
DOI: 10.1073/pnas.1601116113 SCOPUS: 84984876913
Rocha R., Jorge J.M.P., Teixeira-Duarte C.M., Figueiredo-Costa I.R., Cereija T.B., Ferreira-Teixeira P.F., Herzberg C., Stülke J., Morais-Cabral J.H.
c-di-AMP determines the hierarchical organization of bacterial RCK proteins. Proceedings of the National Academy of Sciences of the United States of America121(18):, 2024. [Journal: Article] [IF: 9.4 (*)]
DOI: 10.1073/pnas.2318666121 SCOPUS: 85191240397
Stevens-Sostre W.A., Flores-Aldama L., Bustos D., Li J., Morais-Cabral J.H., Delemotte L., Robertson G.A.
An intracellular hydrophobic nexus critical for hERG1 channel slow deactivation. Biophysical Journal123(14):2024-2037, 2024. [Journal: Article] [CI: 2] [IF: 3.2 (*)]
DOI: 10.1016/j.bpj.2024.01.010 SCOPUS: 85184778601
Rocha R., Teixeira-Duarte C.M., Jorge J.M.P., Morais-Cabral J.H.
Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis. Journal of Structural Biology205(3):34-43, 2019. [Journal: Article] [CI: 20] [IF: 3,1]
DOI: 10.1016/j.jsb.2019.02.002 SCOPUS: 85061548530
c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter. Proceedings of the National Academy of Sciences of the United States of America118(14):, 2021. [Journal: Article] [CI: 22] [IF: 12,8]
DOI: 10.1073/pnas.2020653118 SCOPUS: 85103744229
Harley C.A., Bernardo-Seisdedos G., Stevens-Sostre W.A., Jones D.K., Azevedo M.M., Sampaio P., Lorga-Gomes M., Trudeau M.C., Millet O., Robertson G.A., Morais-Cabral J.H.
Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating. Proceedings of the National Academy of Sciences of the United States of America118(44):, 2021. [Journal: Article] [CI: 5] [IF: 12,8]
DOI: 10.1073/pnas.2108796118 SCOPUS: 85119299559
Teixeira-Duarte C.M., Fonseca F., Morais-Cabral J.H.
Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site. eLife8:, 2019. [Journal: Article] [CI: 10] [IF: 7,1]
DOI: 10.7554/eLife.50661 SCOPUS: 85077594921
Castro-Rodrigues A.F., Zhao Y., Fonseca F., Gabant G., Cadene M., Robertson G.A., Morais-Cabral J.H.
The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase. Journal of Molecular Biology430(24):5029-5049, 2018. [Journal: Article] [CI: 5] [IF: 5,1]
DOI: 10.1016/j.jmb.2018.10.015 SCOPUS: 85056216681
Szollosi A., Vieira-Pires R., Teixeira-Duarte C., Rocha R., Morais-Cabral J.
Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter. PLoS Biology14(1):, 2016. [Journal: Article] [CI: 21] [IF: 9,8]
DOI: 10.1371/journal.pbio.1002356 SCOPUS: 84961353773
Marques-Carvalho M.J., Oppermann J., Muñoz E., Fernandes A.S., Gabant G., Cadene M., Heinemann S.H., Schönherr R., Morais-Cabral J.H.
Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel. Structure24(10):1742-1754, 2016. [Journal: Article] [CI: 10] [IF: 4,9]
DOI: 10.1016/j.str.2016.07.020 SCOPUS: 84989908805
Harley C., Starek G., Jones D., Fernandes A., Robertson G., Morais-Cabral J.
Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain. Proceedings of the National Academy of Sciences of the United States of America113(35):9916-9921, 2016. [Journal: Article] [CI: 16] [IF: 9,7]
DOI: 10.1073/pnas.1601116113 SCOPUS: 84984876913
Rocha R., Jorge J.M.P., Teixeira-Duarte C.M., Figueiredo-Costa I.R., Cereija T.B., Ferreira-Teixeira P.F., Herzberg C., Stülke J., Morais-Cabral J.H.
c-di-AMP determines the hierarchical organization of bacterial RCK proteins. Proceedings of the National Academy of Sciences of the United States of America121(18):, 2024. [Journal: Article] [IF: 9.4 (*)]
DOI: 10.1073/pnas.2318666121 SCOPUS: 85191240397
Stevens-Sostre W.A., Flores-Aldama L., Bustos D., Li J., Morais-Cabral J.H., Delemotte L., Robertson G.A.
An intracellular hydrophobic nexus critical for hERG1 channel slow deactivation. Biophysical Journal123(14):2024-2037, 2024. [Journal: Article] [CI: 2] [IF: 3.2 (*)]
DOI: 10.1016/j.bpj.2024.01.010 SCOPUS: 85184778601
Rocha R., Teixeira-Duarte C.M., Jorge J.M.P., Morais-Cabral J.H.
Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis. Journal of Structural Biology205(3):34-43, 2019. [Journal: Article] [CI: 20] [IF: 3,1]
DOI: 10.1016/j.jsb.2019.02.002 SCOPUS: 85061548530