Where Ideas Grow
Rui Pereira
Associate Researcher

Rui Pereira received a BSc in Applied Biology by University of Minho (PT) and completed the first year of the Master in Processing and Characterization of Materials by the same University. He holds a European PhD in tissue engineering, regenerative medicine and stem cells by the University of Minho (PT) and University of Genova (IT). 

He acquired firm foundations and experience in cellular culture techniques of human primary cells from different tissues, e.g. bone, cartilage, peripherical blood, and stem cells applied to tissue engineering and regenerative medicine models. He has expertise in 2 and 3 D culture systems with and without the use of biomaterials (ceramic scaffolds, hydrogels) for cell expansion and differentiation under physiological and inflammatory conditions. Throughout the same period he gained knowledge on human cellular and molecular immunology events under physiological and pathological conditions.

After, at the Lab. of Nanotechnology for Precision Medicine at the Italian Institute of Technology (IIT) he acquired skills on the use of microfluidic devices as organs on a chip and was responsible for the implementation of functional endothelium on diverse microfluidic chips to dissect vascular and extravascular transport of nanoparticles, tumor cells and pharmacological dynamics under physiological and inflammatory conditions. He developed 3D hydrogels to (co)culture human brain tumor spheroids and somatic brain cells to investigate pharmacological toxicity and delivery efficiency.

In 2018, at the same institute, he joined the Neurobiology of miRNAs lab. where he applied his skill's on 3D culture systems to explore a possible role of miRNAs use as combinatory therapy on glioblastoma and meduloblastoma.

Lately, Rui was awarded with an individual iCARE-2 fellowship (funded by Fondazione AIRC and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 800924) with the project “Nanomedicine targeting Medulloblastoma in a novel xenotransplant model in wild type mice”. 

At the present Rui is member of the Editorial Board of Frontiers of Biotechnology and Bioengineering,  and reviewer for international peer-reviewed journals in the field of Cell and molecular biology, Biomaterials and Biotechnology. 

Selected Publications

Barbato M.G., Pereira R.C., Mollica H., Palange A.L., Ferreira M., Decuzzi P.,
A permeable on-chip microvasculature for assessing the transport of macromolecules and polymeric nanoconstructs. Journal of Colloid and Interface Science594:409-423, 2021. [Journal: Article] [CI: 5] [IF: 10]
DOI: 10.1016/j.jcis.2021.03.053 SCOPUS: 85103097621.


Miali M.E., Colasuonno M., Surdo S., Palomba R., Pereira R., Rondanina E., Diaspro A., Pascazio G., Decuzzi P.,
Leaf-Inspired Authentically Complex Microvascular Networks for Deciphering Biological Transport Process. ACS Applied Materials and Interfaces11(35):31627-31637, 2019. [Journal: Article] [CI: 15] [IF: 8,8]
DOI: 10.1021/acsami.9b09453 SCOPUS: 85071782687.


Manneschi C., Pereira R.C., Marinaro G., Bosca A., Francardi M., Decuzzi P.,
A microfluidic platform with permeable walls for the analysis of vascular and extravascular mass transport. Microfluidics and Nanofluidics20(8):, 2016. [Journal: Article] [CI: 17] [IF: 2,3]
DOI: 10.1007/s10404-016-1775-5 SCOPUS: 84978771832.


Pereira R.C., Santagiuliana R., Ceseracciu L., Boso D.P., Schrefler B.A., Decuzzi P.,
Elucidating the role of matrix porosity and rigidity in glioblastoma type iv progression. Applied Sciences (Switzerland)10(24):1-29, 2020. [Journal: Article] [CI: 4] [IF: 2,7]
DOI: 10.3390/app10249076 SCOPUS: 85098056643.


Hoffmann N., Fernández V., Pereira R.C., Rancati S., Pelizzoli R., De Pietri Tonelli D.,
A Xenotransplant Model of Human Brain Tumors in Wild-Type Mice. iScience23(1):, 2020. [Journal: Article] [CI: 12] [IF: 5,5]
DOI: 10.1016/j.isci.2019.100813 SCOPUS: 85077646794.


Carluccio S., Martinelli D., Palamà M.E.F., Pereira R.C., Benelli R., Guijarro A., Cancedda R., Gentili C.,
Progenitor Cells Activated by Platelet Lysate in Human Articular Cartilage as a Tool for Future Cartilage Engineering and Reparative Strategies. Cells9(4):, 2020. [Journal: Article] [CI: 24] [IF: 6,6]
DOI: 10.3390/cells9041052 SCOPUS: 85084107681.


Pereira R.C., Martinelli D., Cancedda R., Gentili C., Poggi A.,
Human articular chondrocytes regulate immune response by affecting directly T cell proliferation and indirectly inhibiting monocyte differentiation to professional antigen-presenting cells. Frontiers in Immunology7(OCT):, 2016. [Journal: Article] [CI: 18] [IF: 6,4]
DOI: 10.3389/fimmu.2016.00415 SCOPUS: 84997080031.


Martinelli D., Pereira R.C., Mogni M., Benelli R., Mastrogiacomo M., Coviello D., Cancedda R., Gentili C.,
A humanized system to expand in vitro amniotic fluid-derived stem cells intended for clinical application. Cytotherapy18(3):438-451, 2016. [Journal: Article] [CI: 16] [IF: 3,2]
DOI: 10.1016/j.jcyt.2015.11.020 SCOPUS: 84964317966.


Pereira R.C., Scaranari M., Benelli R., Strada P., Reis R.L., Cancedda R., Gentili C.,
Dual effect of platelet lysate on human articular cartilage: A maintenance of chondrogenic potential and a transient proinflammatory activity followed by an inflammation resolution. Tissue Engineering - Part A19(11-12):1476-1488, 2013. [Journal: Article] [CI: 83] [IF: 4,7 (*)]
DOI: 10.1089/ten.tea.2012.0225 SCOPUS: 84876914495.


Pereira R.C., Scaranari M., Castagnola P., Grandizio M., Azevedo H.S., Reis R.L., Cancedda R., Gentili C.,
Novel injectable gel (system) as a vehicle for human articular chondrocytes in cartilage tissue regeneration. Journal of Tissue Engineering and Regenerative Medicine3(2):97-106, 2009. [Journal: Article] [CI: 62] [IF: 3,9]
DOI: 10.1002/term.145 SCOPUS: 66949129792.