I am a Postdoctoral Researcher within the Nanomedicines & Translational Drug Delivery (NTDD) research group. My current project, funded by the European Innovation Council (EIC), is titled "Anticancer approach based on the Metabolic Disruption of Cancer Stem Cells with high effectivity across a wide range of solid tumour." The project focuses on improving the bioavailability of a new compound through nanoformulations. This will enhance its performance in preclinical stages, with the ultimate goal of advancing it to a clinical phase. Previously, I was a Postdoctoral fellow in two different projets, a Marie Skłodowska-Curie (HORIZON-WIDERA-2022-TALENTS-04) working on the development of a multicompartmental model for melanoma and the creation of nanomedicine-based therapies for the treatment of skin cancer, and on a project funded by Litwin Pioneers, where I specialized in the development of ROS-responsive polymeric nanoparticles.
My academic background is rooted in Pharmaceutical Sciences. I began my studies at the Federal University of Ouro Preto (Brazil), earning a Bachelor of Pharmacy between 2011 and 2016. I then pursued a Master's (2017-2019) and Ph.D. (2019-2022) degree at the University of São Paulo (Brazil).
My primary research interests lie in the development and optimization of nanomedicines and the establishment of in vitro and ex vivo models for the screening of innovative cancer therapies.
Selected Publications
Patient-Derived Melanoma Immune-Tumoroids as a Platform for Precise High throughput Drug Screening. Advanced Science11(48):, 2024. [Journal: Article] [CI: 3] [IF: 14.3 (*)]
DOI: 10.1002/advs.202408707 SCOPUS: 85207629059
Viegas J., Sarmento B.
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research. Advanced Drug Delivery Reviews208:, 2024. [Journal: Review] [CI: 23] [IF: 17.6]
DOI: 10.1016/j.addr.2024.115295 SCOPUS: 85188803871
Tavares Luiz M., Santos Rosa Viegas J., Palma Abriata J., Viegas F., Testa Moura de Carvalho Vicentini F., Lopes Badra Bentley M.V., Chorilli M., Maldonado Marchetti J., Tapia-Blácido D.R.
Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics165:127-148, 2021. [Journal: Article] [CI: 150] [IF: 5,6]
DOI: 10.1016/j.ejpb.2021.05.011 SCOPUS: 85108303638
Borgheti-Cardoso L.N., Viegas J.S.R., Silvestrini A.V.P., Caron A.L., Praça F.G., Kravicz M., Bentley M.V.L.B.
Nanotechnology approaches in the current therapy of skin cancer. Advanced Drug Delivery Reviews153:109-136, 2020. [Journal: Review] [CI: 106] [IF: 15,5]
DOI: 10.1016/j.addr.2020.02.005 SCOPUS: 85082647853
Viegas J., Dias S., Carvalho A.M., Sarmento B.
Characterization of a human lesioned-skin model to assess the influence of skin integrity on drug permeability. Biomedicine and Pharmacotherapy169:, 2023. [Journal: Article] [CI: 7] [IF: 6.9]
DOI: 10.1016/j.biopha.2023.115841 SCOPUS: 85178191998
Viegas J.S.R., Araujo J.S., Leite M.N., Praça F.G., Ciampo J.O.D., Espreáfico E.M., Frade M.A.C., Bentley M.V.L.B.
Bcl-2 knockdown by multifunctional lipid nanoparticle and its influence in apoptosis pathway regarding cutaneous melanoma: in vitro and ex vivo studies. Drug Delivery and Translational Research15(2):753-768, 2025. [Journal: Article] [IF: 5.5 (*)]
DOI: 10.1007/s13346-024-01692-w SCOPUS: 85202926665
Leite M.N., Viegas J.S.R., Praça F.S.G., de Paula N.A., Ramalho L.N.Z., Bentley M.V.L.B., Frade M.A.C.
Ex vivo model of human skin (hOSEC) for assessing the dermatokinetics of the anti-melanoma drug Dacarbazine. European Journal of Pharmaceutical Sciences160:, 2021. [Journal: Article] [CI: 17] [IF: 5,1]
DOI: 10.1016/j.ejps.2021.105769 SCOPUS: 85101399208
Viegas J.S.R., Praça F.G., Caron A.L., Suzuki I., Silvestrini A.V.P., Medina W.S.G., Del Ciampo J.O., Kravicz M., Bentley M.V.L.B.
Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis. Drug Delivery and Translational Research10(3):646-660, 2020. [Journal: Article] [CI: 81] [IF: 4,6]
DOI: 10.1007/s13346-020-00723-6 SCOPUS: 85079715734
Viegas J.S.R., Bentley M.V.L.B., Vicentini F.T.M.d.C.
Challenges to perform an efficiently gene therapy adopting non-viral vectors: Melanoma landscape. Journal of Drug Delivery Science and Technology78:, 2022. [Journal: Review] [CI: 7] [IF: 5]
DOI: 10.1016/j.jddst.2022.103964 SCOPUS: 85141973728
Costa S., Rodrigues J., Vieira C., Dias S., Viegas J., Castro F., Sarmento B., Leite Pereira C.
Advancing osteosarcoma 3D modeling in vitro for novel tumor microenvironment-targeted therapies development. Journal of Controlled Release376:1068-1085, 2024. [Journal: Article] [CI: 9] [IF: 11.5]
DOI: 10.1016/j.jconrel.2024.10.068 SCOPUS: 85208199433
Pinto S., Viegas J., Cristelo C., Pacheco C., Barros S., Buckley S.T., Garousi J., Gräslund T., Santos H.A., Sarmento B.
Bioengineered Nanomedicines Targeting the Intestinal Fc Receptor Achieve the Improved Glucoregulatory Effect of Semaglutide in a Type 2 Diabetic Mice Model. ACS Nano18(41):28406-28424, 2024. [Journal: Article] [CI: 10] [IF: 16]
DOI: 10.1021/acsnano.4c11172 SCOPUS: 85205766209
Barros A.S., Pinto S., Viegas J., Martins C., Almeida H., Alves I., Pinho S., Nunes R., Harris A., Sarmento B.
Orally Delivered Stimulus-Sensitive Nanomedicine to Harness Teduglutide Efficacy in Inflammatory Bowel Disease. Small20(45):, 2024. [Journal: Article] [CI: 15] [IF: 12.1]
DOI: 10.1002/smll.202402502 SCOPUS: 85198399661
