creating a
healthier future
Camila Portugal
Junior Researcher
Camila Cabral Portugal obtained her BSc. degree in Biology in 2006, her master in Neuroimmunology in 2008 and her PhD, also in Neuroimmunology in 2012 at the Federal Fluminense University, in Brazil. During her PhD, Camila C. Portugal worked at the Biology Institute, at the Federal Fluminense University in Brazil and at the Centre of Ophthalmology and Vision Sciences, IBILI, at the University of Coimbra, in Portugal, in a split-site doctoral program from CAPES/FCT in a project entitled Vitamin C transport modulation in the Central Nervous System. Her PhD thesis received an Honorable Mention from the national Brazilian funding agency Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Afterwards, Camila C. Portugal started working as a postdoctoral research fellow at the Institute for Molecular and Cell Biology (IBMC), Portugal. She published 29 articles in peer-reviewed journals (Times cited: 403; H index: 13 - Web of Science april/2020). Her last work in Science Signaling was very well accepted by the scientific community receiving highlights on two prestigious journals: one in Science by Dr. Annalisa VanHook and another in Nature Immunology by Dr. Laurie A. Dempsey. Camila published 6 book chapters, co-supervised 2 PhD thesis(es), supervised 1 MSc dissertation(s) and co-supervised 3. She also supervised 2 BSc final works and co-supervised 2. She has received 18 awards and/or honors. Now, Camila C. Portugal is a Junior researcher at Instituto de Investigação e Inovação em Saúde, i3S. She works in the area(s) of Medical and Health Sciences (Basic Medicine) with emphasis on Neurosciences. She develops a scientific project entitled "Regulation of microglia inflammatory profile by high affinity ascorbate transporter and its implication for Alzheimer´s Disease".

Selected Publications

Portugal C.C., Socodato R., Canedo T., Silva C.M., Martins T., Coreixas V.S.M., Loiola E.C., Gess B., Röhr D., Santiago A.R., Young P., Minshall R.D., Paes-De-Carvalho R., Ambrósio A.F., Relvas J.B.,
Caveolin-1-mediated internalization of the Vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype. Science Signaling10(472):, 2017. [Journal: Article] [CI: 52] [IF: 6,4]
DOI: 10.1126/scisignal.aal2005 SCOPUS: 85017537219.


Portugal C.C., Socodato R., Relvas J.B.,
The ascorbate transporter SVCT2 to target microglia-dependent inflammation. Oncotarget8(59):99217-99218, 2017. [Journal: Editorial] [CI: 3] [IF: 5,2 (*)]
DOI: 10.18632/oncotarget.22306 SCOPUS: 85034625017.


Portugal C.C., Da Encarnação T.G., Socodato R., Moreira S.R., Brudzewsky D., Ambrósio A.F., Paes-de-Carvalho R.,
Nitric oxide modulates sodium vitamin C transporter 2 (SVCT-2) protein expression via protein kinase G (PKG) and nuclear factor-κB (NF-κB). Journal of Biological Chemistry287(6):3860-3872, 2012. [Journal: Article] [CI: 40] [IF: 4,7]
DOI: 10.1074/jbc.M111.260166 SCOPUS: 84856692905.


Portugal C.C., Miya V.S., Calaza K.D.C., Santos R.A.M., Paes-De-Carvalho R.,
Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bidirectional transport in cultured avian retinal cells. Journal of Neurochemistry108(2):507-520, 2009. [Journal: Article] [CI: 36] [IF: 4]
DOI: 10.1111/j.1471-4159.2008.05786.x SCOPUS: 57549085174.


Portugal C.C., Da Encarnacaõ T.G., Domith I., Dos Santos Rodrigues A., De Oliveira N.A., Socodato R., Paes-De-carvalho R.,
Dopamine-induced ascorbate release from retinal neurons involves glutamate release, activation of AMPA/Kainate receptors and downstream signaling pathways. Frontiers in Neuroscience13(MAY):, 2019. [Journal: Article] [CI: 8] [IF: 3,7]
DOI: 10.3389/fnins.2019.00453 SCOPUS: 85068545410.


da Encarnação T.G., Portugal C.C., Nogueira C.E., Santiago F.N., Socodato R., Paes-de-Carvalho R.,
Dopamine Promotes Ascorbate Release from Retinal Neurons: Role of D1 Receptors and the Exchange Protein Directly Activated by cAMP type 2 (EPAC2). Molecular Neurobiology55(10):7858-7871, 2018. [Journal: Article] [CI: 13] [IF: 4,6]
DOI: 10.1007/s12035-018-0962-7 SCOPUS: 85045150597.


Domith I., Socodato R., Portugal C.C., Munis A.F., Duarte-Silva A.T., Paes-de-Carvalho R.,
Vitamin C modulates glutamate transport and NMDA receptor function in the retina. Journal of Neurochemistry144(4):408-420, 2018. [Journal: Article] [CI: 27] [IF: 4,9]
DOI: 10.1111/jnc.14260 SCOPUS: 85038024824.


Socodato R., Brito R., Portugal C.C., De Oliveira N.A., Calaza K.C., Paes-De-Carvalho R.,
The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation. Cell Death and Differentiation21(6):915-928, 2014. [Journal: Article] [CI: 22] [IF: 8,2]
DOI: 10.1038/cdd.2014.11 SCOPUS: 84899978192.


Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.,
A mouse model reproducing the pathophysiology of neonatal groupαB streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 41] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907.


Socodato R., Portugal C.C., Domith I., Oliveira N.A., Coreixas V.S.M., Loiola E.C., Martins T., Santiago A.R., Paes-de-Carvalho R., Ambrósio A.F., Relvas J.B.,
c-Src function is necessary and sufficient for triggering microglial cell activation. GLIA63(3):497-511, 2015. [Journal: Article] [CI: 36] [IF: 6]
DOI: 10.1002/glia.22767 SCOPUS: 84920940260.