Vítor Costa
Yeast Signalling Networks
Group leader
Vítor Costa obtained a Biochemistry degree at University of Porto (UP) and a PhD in Biomedical Sciences at ICBAS-UP. In 1998, he was recruited as Assistant Professor at ICBAS where he currently holds a position as Associate Professor. He is principal investigator at IBMC since 2002 and became group leader in 2011. Using the yeast Saccharomyces cerevisiae as model organism, his research focuses on the role of bioactive sphingolipids and nutrient signalling pathways in the regulation of cellular processes, namely mitochondrial function, redox homeostasis, proteostasis and apoptosis, and how deregulation of these signalling networks impacts on aging and cell death in the context of neurodegenerative diseases.
Selected Publications
Teixeira V., Medeiros T.C., Vilaça R., Ferreira J., Moradas-Ferreira P., Costa V.,
Teixeira V., Costa V.,
Vilaça R., Silva E., Nadais A., Teixeira V., Matmati N., Gaifem J., Hannun Y.A., Sá Miranda M.C., Costa V.,
Barbosa A.D., Osório H., Sims K.J., Almeida T., Alves M., Bielawski J., Amorim M.A., Moradas-Ferreira P., Hannun Y.A., Costa V.,
Mesquita A., Weinberger M., Silva A., Sampaio-Marques B., Almeida B., Leão C., Costa V., Rodrigues F., Burhans W.C., Ludovico P.,
Almeida T., Marques M., Mojzita D., Amorim M.A., Silva R.D., Almeida B., Rodrigues P., Ludovico P., Hohmann S., Moradas-Ferreira P., Côrte-Real M., Costa V.,
Martins T.S., Pereira C., Canadell D., Vilaça R., Teixeira V., Moradas-Ferreira P., de Nadal E., Posas F., Costa V.,
Vilaça R., Barros I., Matmati N., Silva E., Martins T., Teixeira V., Hannun Y.A., Costa V.,
Teixeira V., Martins T.S., Prinz W.A., Costa V.,
Teixeira V., Maciel P., Costa V.,
Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids1861(1):21-33, 2016. [Journal: Article] [CI: 15] [IF: 5,5]
DOI: 10.1016/j.bbalip.2015.10.004 SCOPUS: 84944937082.
DOI: 10.1016/j.bbalip.2015.10.004 SCOPUS: 84944937082.
Teixeira V., Costa V.,
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism. Progress in Lipid Research61:109-133, 2016. [Journal: Review] [CI: 34] [IF: 10,6]
DOI: 10.1016/j.plipres.2015.11.001 SCOPUS: 84952328556.
DOI: 10.1016/j.plipres.2015.11.001 SCOPUS: 84952328556.
Vilaça R., Silva E., Nadais A., Teixeira V., Matmati N., Gaifem J., Hannun Y.A., Sá Miranda M.C., Costa V.,
Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Molecular Microbiology91(3):438-451, 2014. [Journal: Article] [CI: 28] [IF: 4,4]
DOI: 10.1111/mmi.12470 SCOPUS: 84908101723.
DOI: 10.1111/mmi.12470 SCOPUS: 84908101723.
Barbosa A.D., Osório H., Sims K.J., Almeida T., Alves M., Bielawski J., Amorim M.A., Moradas-Ferreira P., Hannun Y.A., Costa V.,
Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Molecular Microbiology81(2):515-527, 2011. [Journal: Article] [CI: 44] [IF: 5]
DOI: 10.1111/j.1365-2958.2011.07714.x SCOPUS: 79960193275.
DOI: 10.1111/j.1365-2958.2011.07714.x SCOPUS: 79960193275.
Mesquita A., Weinberger M., Silva A., Sampaio-Marques B., Almeida B., Leão C., Costa V., Rodrigues F., Burhans W.C., Ludovico P.,
Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. Proceedings of the National Academy of Sciences of the United States of America107(34):15123-15128, 2010. [Journal: Article] [CI: 223] [IF: 9,8]
DOI: 10.1073/pnas.1004432107 SCOPUS: 77956987110.
DOI: 10.1073/pnas.1004432107 SCOPUS: 77956987110.
Almeida T., Marques M., Mojzita D., Amorim M.A., Silva R.D., Almeida B., Rodrigues P., Ludovico P., Hohmann S., Moradas-Ferreira P., Côrte-Real M., Costa V.,
Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. Molecular Biology of the Cell19(3):865-876, 2008. [Journal: Article] [CI: 81] [IF: 5,6]
DOI: 10.1091/mbc.E07-06-0604 SCOPUS: 41649101223.
DOI: 10.1091/mbc.E07-06-0604 SCOPUS: 41649101223.
Martins T.S., Pereira C., Canadell D., Vilaça R., Teixeira V., Moradas-Ferreira P., de Nadal E., Posas F., Costa V.,
The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids1863(1):61-70, 2018. [Journal: Article] [CI: 16] [IF: 4,4]
DOI: 10.1016/j.bbalip.2017.10.001 SCOPUS: 85032229876.
DOI: 10.1016/j.bbalip.2017.10.001 SCOPUS: 85032229876.
Vilaça R., Barros I., Matmati N., Silva E., Martins T., Teixeira V., Hannun Y.A., Costa V.,
The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. Biochimica et Biophysica Acta - Molecular Basis of Disease1864(1):79-88, 2018. [Journal: Article] [CI: 10] [IF: 4,3]
DOI: 10.1016/j.bbadis.2017.10.010 SCOPUS: 85031804747.
DOI: 10.1016/j.bbadis.2017.10.010 SCOPUS: 85031804747.
Teixeira V., Martins T.S., Prinz W.A., Costa V.,
Target of rapamycin complex 1 (Torc1), protein kinase a (pka) and cytosolic ph regulate a transcriptional circuit for lipid droplet formation. International Journal of Molecular Sciences22(16):, 2021. [Journal: Article] [CI: 7] [IF: 6,2]
DOI: 10.3390/ijms22169017 SCOPUS: 85113246359.
DOI: 10.3390/ijms22169017 SCOPUS: 85113246359.
Teixeira V., Maciel P., Costa V.,
Leading the way in the nervous system: Lipid Droplets as new players in health and disease. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids1866(1):, 2021. [Journal: Review] [CI: 23] [IF: 5,2]
DOI: 10.1016/j.bbalip.2020.158820 SCOPUS: 85092135819.
DOI: 10.1016/j.bbalip.2020.158820 SCOPUS: 85092135819.