Teresa Summavielle
Addiction Biology
Group leader
Teresa Summavielle has a degree in biochemistry and a PhD in developmental neurotoxicology. Presently she coordinates the Neurobiology and Neurologic Disorders integrative program at i3S, where she is also Vice-Director and Head of the Addiction Biology Group. Her research explores the crosstalk between neurons and glial cells under exposure to psychoactive substances and has a strong focus on neuro-immune regulation. She coordinates courses in Neurobiology of Addiction and Neurotoxicology in doctoral and master programs (University of Porto) and she is an invited professor at the Escola Superior de Saúde (Polytechnic University).Advocating for responsible experimentation, she integrates the CARE committee at FENS. On a societal perspective, she runs since 2008 a science-based campaign to prevent drug use by the adolescent population and is an acting city council women at the municipality of Porto.
Selected Publications
Bravo J., Ribeiro I., Terceiro A.F., Andrade E.B., Portugal C.C., Lopes I.M., Azevedo M.M., Sousa M., Lopes C.D.F., Lobo A.C., Canedo T., Relvas J.B., Summavielle T.
Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity. Cells11(3):, 2022. [Journal: Article] [CI: 9] [IF: 6]
DOI: 10.3390/cells11030355 SCOPUS: 85124679532
Canedo T., Portugal C.C., Socodato R., Almeida T.O., Terceiro A.F., Bravo J., Silva A.I., Magalhães J.D., Guerra-Gomes S., Oliveira J.F., Sousa N., Magalhães A., Relvas J.B., Summavielle T.
Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine. Neuropsychopharmacology46(13):2358-2370, 2021. [Journal: Article] [CI: 46] [IF: 8,3]
DOI: 10.1038/s41386-021-01139-7 SCOPUS: 85112725396
Socodato R., Henriques J.F., Portugal C.C., Almeida T.O., Tedim-Moreira J., Alves R.L., Canedo T., Silva C., Magalhães A., Summavielle T., Relvas J.B.
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. Science Signaling13(650):, 2020. [Journal: Article] [CI: 41] [IF: 8,2]
DOI: 10.1126/scisignal.aba5754 SCOPUS: 85091580054
Socodato R., Portugal C.C., Canedo T., Rodrigues A., Almeida T.O., Henriques J.F., Vaz S.H., Magalhães J., Silva C.M., Baptista F.I., Alves R.L., Coelho-Santos V., Silva A.P., Paes-de-Carvalho R., Magalhães A., Brakebusch C., Sebastião A.M., Summavielle T., Ambrósio A.F., Relvas J.B.
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell Reports31(12):, 2020. [Journal: Article] [CI: 53] [IF: 9,4]
DOI: 10.1016/j.celrep.2020.107796 SCOPUS: 85087074279
Brás J.P., Bravo J., Freitas J., Barbosa M.A., Santos S.G., Summavielle T., Almeida M.I.
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell Death and Disease11(6):, 2020. [Journal: Article] [CI: 128] [IF: 8,5]
DOI: 10.1038/s41419-020-2626-6 SCOPUS: 85085909806
Alves R.L., Portugal C.C., Summavielle T., Barbosa F., Magalhães A.
Maternal separation effects on mother rodents’ behaviour: A systematic review. Neuroscience and Biobehavioral Reviews117:98-109, 2020. [Journal: Review] [CI: 43] [IF: 9]
DOI: 10.1016/j.neubiorev.2019.09.008 SCOPUS: 85072168455
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.
A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 50] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907
Fernandes S., Salta S., Bravo J., Silva A.P., Summavielle T.
Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity. Molecular Neurobiology53(1):408-422, 2016. [Journal: Article] [CI: 22] [IF: 6,2]
DOI: 10.1007/s12035-014-8973-5 SCOPUS: 84953357442
Coelho-Santos V., Socodato R., Portugal C., Leitão R.A., Rito M., Barbosa M., Couraud P.O., Romero I.A., Weksler B., Minshall R.D., Fontes-Ribeiro C., Summavielle T., Relvas J.B., Silva A.P.
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Cellular and Molecular Life Sciences73(24):4701-4716, 2016. [Journal: Article] [CI: 28] [IF: 5,8]
DOI: 10.1007/s00018-016-2301-3 SCOPUS: 84976878471
Teixeira-Castro A., Jalles A., Esteves S., Kang S., Da Silva Santos L., Silva-Fernandes A., Neto M.F., Brielmann R.M., Bessa C., Duarte-Silva S., Miranda A., Oliveira S., Neves-Carvalho A., Bessa J., Summavielle T., Silverman R.B., Oliveira P., Morimoto R.I., Maciel P.
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain138(11):3221-3237, 2015. [Journal: Article] [CI: 70] [IF: 10,1]
DOI: 10.1093/brain/awv262 SCOPUS: 84947806720
Ribeiro Do Couto B., Daza-Losada M., Rodríguez-Arias M., Nadal R., Guerri C., Summavielle T., Miñarro J., Aguilar M.A.
Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug-induced reinstatement. Addiction Biology17(3):588-600, 2012. [Journal: Article] [CI: 23] [IF: 5,9]
DOI: 10.1111/j.1369-1600.2011.00382.x SCOPUS: 84860240599
Alves E., Summavielle T., Alves C.J., Gomes-da-Silva J., Barata J.C., Fernandes E., Bastos M.D.L., Tavares M.A., Carvalho F.
Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. Journal of Neuroscience27(38):10203-10210, 2007. [Journal: Article] [CI: 66] [IF: 7,5]
DOI: 10.1523/JNEUROSCI.2645-07.2007 SCOPUS: 34548842751
Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity. Cells11(3):, 2022. [Journal: Article] [CI: 9] [IF: 6]
DOI: 10.3390/cells11030355 SCOPUS: 85124679532
Canedo T., Portugal C.C., Socodato R., Almeida T.O., Terceiro A.F., Bravo J., Silva A.I., Magalhães J.D., Guerra-Gomes S., Oliveira J.F., Sousa N., Magalhães A., Relvas J.B., Summavielle T.
Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine. Neuropsychopharmacology46(13):2358-2370, 2021. [Journal: Article] [CI: 46] [IF: 8,3]
DOI: 10.1038/s41386-021-01139-7 SCOPUS: 85112725396
Socodato R., Henriques J.F., Portugal C.C., Almeida T.O., Tedim-Moreira J., Alves R.L., Canedo T., Silva C., Magalhães A., Summavielle T., Relvas J.B.
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. Science Signaling13(650):, 2020. [Journal: Article] [CI: 41] [IF: 8,2]
DOI: 10.1126/scisignal.aba5754 SCOPUS: 85091580054
Socodato R., Portugal C.C., Canedo T., Rodrigues A., Almeida T.O., Henriques J.F., Vaz S.H., Magalhães J., Silva C.M., Baptista F.I., Alves R.L., Coelho-Santos V., Silva A.P., Paes-de-Carvalho R., Magalhães A., Brakebusch C., Sebastião A.M., Summavielle T., Ambrósio A.F., Relvas J.B.
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell Reports31(12):, 2020. [Journal: Article] [CI: 53] [IF: 9,4]
DOI: 10.1016/j.celrep.2020.107796 SCOPUS: 85087074279
Brás J.P., Bravo J., Freitas J., Barbosa M.A., Santos S.G., Summavielle T., Almeida M.I.
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell Death and Disease11(6):, 2020. [Journal: Article] [CI: 128] [IF: 8,5]
DOI: 10.1038/s41419-020-2626-6 SCOPUS: 85085909806
Alves R.L., Portugal C.C., Summavielle T., Barbosa F., Magalhães A.
Maternal separation effects on mother rodents’ behaviour: A systematic review. Neuroscience and Biobehavioral Reviews117:98-109, 2020. [Journal: Review] [CI: 43] [IF: 9]
DOI: 10.1016/j.neubiorev.2019.09.008 SCOPUS: 85072168455
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.
A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 50] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907
Fernandes S., Salta S., Bravo J., Silva A.P., Summavielle T.
Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity. Molecular Neurobiology53(1):408-422, 2016. [Journal: Article] [CI: 22] [IF: 6,2]
DOI: 10.1007/s12035-014-8973-5 SCOPUS: 84953357442
Coelho-Santos V., Socodato R., Portugal C., Leitão R.A., Rito M., Barbosa M., Couraud P.O., Romero I.A., Weksler B., Minshall R.D., Fontes-Ribeiro C., Summavielle T., Relvas J.B., Silva A.P.
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Cellular and Molecular Life Sciences73(24):4701-4716, 2016. [Journal: Article] [CI: 28] [IF: 5,8]
DOI: 10.1007/s00018-016-2301-3 SCOPUS: 84976878471
Teixeira-Castro A., Jalles A., Esteves S., Kang S., Da Silva Santos L., Silva-Fernandes A., Neto M.F., Brielmann R.M., Bessa C., Duarte-Silva S., Miranda A., Oliveira S., Neves-Carvalho A., Bessa J., Summavielle T., Silverman R.B., Oliveira P., Morimoto R.I., Maciel P.
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain138(11):3221-3237, 2015. [Journal: Article] [CI: 70] [IF: 10,1]
DOI: 10.1093/brain/awv262 SCOPUS: 84947806720
Ribeiro Do Couto B., Daza-Losada M., Rodríguez-Arias M., Nadal R., Guerri C., Summavielle T., Miñarro J., Aguilar M.A.
Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug-induced reinstatement. Addiction Biology17(3):588-600, 2012. [Journal: Article] [CI: 23] [IF: 5,9]
DOI: 10.1111/j.1369-1600.2011.00382.x SCOPUS: 84860240599
Alves E., Summavielle T., Alves C.J., Gomes-da-Silva J., Barata J.C., Fernandes E., Bastos M.D.L., Tavares M.A., Carvalho F.
Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. Journal of Neuroscience27(38):10203-10210, 2007. [Journal: Article] [CI: 66] [IF: 7,5]
DOI: 10.1523/JNEUROSCI.2645-07.2007 SCOPUS: 34548842751