Teresa Summavielle
Addiction Biology
Group leader
Teresa Summavielle has a degree in biochemistry and a PhD in developmental neurotoxicology. Presently she coordinates the Neurobiology and Neurologic Disorders integrative program at i3S, where she is also Vice-Director and Head of the Addiction Biology Group. Her research explores the crosstalk between neurons and glial cells under exposure to psychoactive substances and has a strong focus on neuro-immune regulation. She coordinates courses in Neurobiology of Addiction and Neurotoxicology in doctoral and master programs (University of Porto) and she is an invited professor at the Escola Superior de Saúde (Polytechnic University).Advocating for responsible experimentation, she integrates the CARE committee at FENS. On a societal perspective, she runs since 2008 a science-based campaign to prevent drug use by the adolescent population and is an acting city council women at the municipality of Porto.
Selected Publications
Bravo J., Ribeiro I., Terceiro A.F., Andrade E.B., Portugal C.C., Lopes I.M., Azevedo M.M., Sousa M., Lopes C.D.F., Lobo A.C., Canedo T., Relvas J.B., Summavielle T.,
Canedo T., Portugal C.C., Socodato R., Almeida T.O., Terceiro A.F., Bravo J., Silva A.I., Magalhães J.D., Guerra-Gomes S., Oliveira J.F., Sousa N., Magalhães A., Relvas J.B., Summavielle T.,
Socodato R., Henriques J.F., Portugal C.C., Almeida T.O., Tedim-Moreira J., Alves R.L., Canedo T., Silva C., Magalhães A., Summavielle T., Relvas J.B.,
Socodato R., Portugal C.C., Canedo T., Rodrigues A., Almeida T.O., Henriques J.F., Vaz S.H., Magalhães J., Silva C.M., Baptista F.I., Alves R.L., Coelho-Santos V., Silva A.P., Paes-de-Carvalho R., Magalhães A., Brakebusch C., Sebastião A.M., Summavielle T., Ambrósio A.F., Relvas J.B.,
Brás J.P., Bravo J., Freitas J., Barbosa M.A., Santos S.G., Summavielle T., Almeida M.I.,
Alves R.L., Portugal C.C., Summavielle T., Barbosa F., Magalhães A.,
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.,
Fernandes S., Salta S., Bravo J., Silva A.P., Summavielle T.,
Coelho-Santos V., Socodato R., Portugal C., Leitão R.A., Rito M., Barbosa M., Couraud P.O., Romero I.A., Weksler B., Minshall R.D., Fontes-Ribeiro C., Summavielle T., Relvas J.B., Silva A.P.,
Teixeira-Castro A., Jalles A., Esteves S., Kang S., Da Silva Santos L., Silva-Fernandes A., Neto M.F., Brielmann R.M., Bessa C., Duarte-Silva S., Miranda A., Oliveira S., Neves-Carvalho A., Bessa J., Summavielle T., Silverman R.B., Oliveira P., Morimoto R.I., Maciel P.,
Ribeiro Do Couto B., Daza-Losada M., Rodríguez-Arias M., Nadal R., Guerri C., Summavielle T., Miñarro J., Aguilar M.A.,
Alves E., Summavielle T., Alves C.J., Gomes-da-Silva J., Barata J.C., Fernandes E., Bastos M.D.L., Tavares M.A., Carvalho F.,
Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity. Cells11(3):, 2022. [Journal: Article] [CI: 6] [IF: 6]
DOI: 10.3390/cells11030355 SCOPUS: 85124679532.
DOI: 10.3390/cells11030355 SCOPUS: 85124679532.
Canedo T., Portugal C.C., Socodato R., Almeida T.O., Terceiro A.F., Bravo J., Silva A.I., Magalhães J.D., Guerra-Gomes S., Oliveira J.F., Sousa N., Magalhães A., Relvas J.B., Summavielle T.,
Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine. Neuropsychopharmacology46(13):2358-2370, 2021. [Journal: Article] [CI: 27] [IF: 8,3]
DOI: 10.1038/s41386-021-01139-7 SCOPUS: 85112725396.
DOI: 10.1038/s41386-021-01139-7 SCOPUS: 85112725396.
Socodato R., Henriques J.F., Portugal C.C., Almeida T.O., Tedim-Moreira J., Alves R.L., Canedo T., Silva C., Magalhães A., Summavielle T., Relvas J.B.,
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior. Science Signaling13(650):, 2020. [Journal: Article] [CI: 29] [IF: 8,2]
DOI: 10.1126/scisignal.aba5754 SCOPUS: 85091580054.
DOI: 10.1126/scisignal.aba5754 SCOPUS: 85091580054.
Socodato R., Portugal C.C., Canedo T., Rodrigues A., Almeida T.O., Henriques J.F., Vaz S.H., Magalhães J., Silva C.M., Baptista F.I., Alves R.L., Coelho-Santos V., Silva A.P., Paes-de-Carvalho R., Magalhães A., Brakebusch C., Sebastião A.M., Summavielle T., Ambrósio A.F., Relvas J.B.,
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell Reports31(12):, 2020. [Journal: Article] [CI: 44] [IF: 9,4]
DOI: 10.1016/j.celrep.2020.107796 SCOPUS: 85087074279.
DOI: 10.1016/j.celrep.2020.107796 SCOPUS: 85087074279.
Brás J.P., Bravo J., Freitas J., Barbosa M.A., Santos S.G., Summavielle T., Almeida M.I.,
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell Death and Disease11(6):, 2020. [Journal: Article] [CI: 84] [IF: 8,5]
DOI: 10.1038/s41419-020-2626-6 SCOPUS: 85085909806.
DOI: 10.1038/s41419-020-2626-6 SCOPUS: 85085909806.
Alves R.L., Portugal C.C., Summavielle T., Barbosa F., Magalhães A.,
Maternal separation effects on mother rodents’ behaviour: A systematic review. Neuroscience and Biobehavioral Reviews117:98-109, 2020. [Journal: Review] [CI: 29] [IF: 9]
DOI: 10.1016/j.neubiorev.2019.09.008 SCOPUS: 85072168455.
DOI: 10.1016/j.neubiorev.2019.09.008 SCOPUS: 85072168455.
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.,
A mouse model reproducing the pathophysiology of neonatal groupαB streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 41] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907.
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907.
Fernandes S., Salta S., Bravo J., Silva A.P., Summavielle T.,
Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity. Molecular Neurobiology53(1):408-422, 2016. [Journal: Article] [CI: 21] [IF: 6,2]
DOI: 10.1007/s12035-014-8973-5 SCOPUS: 84953357442.
DOI: 10.1007/s12035-014-8973-5 SCOPUS: 84953357442.
Coelho-Santos V., Socodato R., Portugal C., Leitão R.A., Rito M., Barbosa M., Couraud P.O., Romero I.A., Weksler B., Minshall R.D., Fontes-Ribeiro C., Summavielle T., Relvas J.B., Silva A.P.,
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Cellular and Molecular Life Sciences73(24):4701-4716, 2016. [Journal: Article] [CI: 26] [IF: 5,8]
DOI: 10.1007/s00018-016-2301-3 SCOPUS: 84976878471.
DOI: 10.1007/s00018-016-2301-3 SCOPUS: 84976878471.
Teixeira-Castro A., Jalles A., Esteves S., Kang S., Da Silva Santos L., Silva-Fernandes A., Neto M.F., Brielmann R.M., Bessa C., Duarte-Silva S., Miranda A., Oliveira S., Neves-Carvalho A., Bessa J., Summavielle T., Silverman R.B., Oliveira P., Morimoto R.I., Maciel P.,
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain138(11):3221-3237, 2015. [Journal: Article] [CI: 65] [IF: 10,1]
DOI: 10.1093/brain/awv262 SCOPUS: 84947806720.
DOI: 10.1093/brain/awv262 SCOPUS: 84947806720.
Ribeiro Do Couto B., Daza-Losada M., Rodríguez-Arias M., Nadal R., Guerri C., Summavielle T., Miñarro J., Aguilar M.A.,
Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug-induced reinstatement. Addiction Biology17(3):588-600, 2012. [Journal: Article] [CI: 23] [IF: 5,9]
DOI: 10.1111/j.1369-1600.2011.00382.x SCOPUS: 84860240599.
DOI: 10.1111/j.1369-1600.2011.00382.x SCOPUS: 84860240599.
Alves E., Summavielle T., Alves C.J., Gomes-da-Silva J., Barata J.C., Fernandes E., Bastos M.D.L., Tavares M.A., Carvalho F.,
Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. Journal of Neuroscience27(38):10203-10210, 2007. [Journal: Article] [CI: 64] [IF: 7,5]
DOI: 10.1523/JNEUROSCI.2645-07.2007 SCOPUS: 34548842751.
DOI: 10.1523/JNEUROSCI.2645-07.2007 SCOPUS: 34548842751.