Where Ideas Grow
Luís Gales
Senior Researcher

Associate Professor of Biophysics at Instituto de Ciências Biomédicas Abel Salazar ? UP. Applies X-ray diffraction techniques complemented with other biophysical methods to 1) elucidate the structure and function of proteins with biomedical or bioengineering interest and to 2) characterize supramolecular arrangements (amyloid, design of biomaterials). Authors more than 100 papers.

Selected Publications

Leite J.P., Figueira F., Mendes R.F., Almeida Paz F.A., Gales L.,
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases. ACS Sensors8(3):1033-1053, 2023. [Journal: Review] [CI: 4] [IF: 8,9 (*)]
DOI: 10.1021/acssensors.2c02741 SCOPUS: 85149840593.

Mendes R.F., Figueira F., Leite J.P., Gales L., Almeida Paz F.A.,
Metal-organic frameworks: A future toolbox for biomedicine?. Chemical Society Reviews49(24):9121-9153, 2020. [Journal: Review] [CI: 118] [IF: 54,6]
DOI: 10.1039/d0cs00883d SCOPUS: 85097887408.

Leite J.P., Mota R., Durão J., Neves S.C., Barrias C.C., Tamagnini P., Gales L.,
Cyanobacterium-Derived Extracellular Carbohydrate Polymer for the Controlled Delivery of Functional Proteins. Macromolecular Bioscience17(2):, 2017. [Journal: Article] [CI: 16] [IF: 3,4]
DOI: 10.1002/mabi.201600206 SCOPUS: 84988663806.

Castro-Rodrigues A.F., Gales L., Saraiva M.J., Damas A.M.,
Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils. Acta Crystallographica Section D: Biological Crystallography67(12):1035-1044, 2011. [Journal: Article] [CI: 14] [IF: 12,6]
DOI: 10.1107/S090744491104491X SCOPUS: 82455198838.

Buttachon S., Chandrapatya A., Manoch L., Silva A., Gales L., Bruyère C., Kiss R., Kijjoa A.,
Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349). Tetrahedron68(15):3253-3262, 2012. [Journal: Article] [CI: 71] [IF: 2,8]
DOI: 10.1016/j.tet.2012.02.024 SCOPUS: 84858707940.

Afonso R.V., Durão J., Mendes A., Damas A.M., Gales L.,
Dipeptide crystals as excellent permselective materials: Sequential exclusion of argon, nitrogen, and oxygen. Angewandte Chemie - International Edition49(17):3034-3036, 2010. [Journal: Article] [CI: 59] [IF: 12,7]
DOI: 10.1002/anie.201000007 SCOPUS: 77951172416.

Gales L., Cortes L., Almeida C., Melo C.V., Costa M.D.C., Maciel P., Clarke D.T., Damas A.M., Macedo-Ribeiro S.,
Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: Trapping early oligomers of non-expanded ataxin-3. Journal of Molecular Biology353(3):642-654, 2005. [Journal: Article] [CI: 64] [IF: 5,2]
DOI: 10.1016/j.jmb.2005.08.061 SCOPUS: 26244434741.

Gales L., Macedo-Ribeiro S., Arsequell G., Valencia G., Saraiva M.J., Damas A.M.,
Human transthyretin in complex with iododiflunisal: Structural features associated with a potent amyloid inhibitor. Biochemical Journal388(2):615-621, 2005. [Journal: Article] [CI: 54] [IF: 4,2]
DOI: 10.1042/BJ20042035 SCOPUS: 20544432502.

Durão J., Vale N., Gomes S., Gomes P., Barrias C.C., Gales L.,
Nitric oxide release from antimicrobial peptide hydrogels for wound healing. Biomolecules9(1):, 2019. [Journal: Article] [CI: 18] [IF: 4,1]
DOI: 10.3390/biom9010004 SCOPUS: 85058910600.

Afonso R., Mendes A., Gales L.,
Peptide-based solids: Porosity and zeolitic behavior. Journal of Materials Chemistry22(5):1709-1723, 2012. [Journal: Review] [CI: 47] [IF: 6,1]
DOI: 10.1039/c1jm13568f SCOPUS: 84855666967.