Luís Gales
Bioengineering & Synthetic Microbiology
Senior Researcher
Associate Professor of Biophysics at Instituto de Ciências Biomédicas Abel Salazar ? UP. Applies X-ray diffraction techniques complemented with other biophysical methods to 1) elucidate the structure and function of proteins with biomedical or bioengineering interest and to 2) characterize supramolecular arrangements (amyloid, design of biomaterials). Authors more than 100 papers.
Selected Publications
Leite J.P., Figueira F., Mendes R.F., Almeida Paz F.A., Gales L.
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases. ACS Sensors8(3):1033-1053, 2023. [Journal: Review] [CI: 31] [IF: 8,9 (*)]
DOI: 10.1021/acssensors.2c02741 SCOPUS: 85149840593
Mendes R.F., Figueira F., Leite J.P., Gales L., Almeida Paz F.A.
Metal-organic frameworks: A future toolbox for biomedicine?. Chemical Society Reviews49(24):9121-9153, 2020. [Journal: Review] [CI: 169] [IF: 54,6]
DOI: 10.1039/d0cs00883d SCOPUS: 85097887408
Leite J., Mota R., Durão J., Neves S., Barrias C., Tamagnini P., Gales L.
Cyanobacterium-Derived Extracellular Carbohydrate Polymer for the Controlled Delivery of Functional Proteins. Macromolecular Bioscience17(2):, 2017. [Journal: Article] [CI: 20] [IF: 3,4]
DOI: 10.1002/mabi.201600206 SCOPUS: 84988663806
Castro-Rodrigues A., Gales L., Saraiva M., Damas A.
Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils. Acta Crystallographica Section D: Biological Crystallography67(12):1035-1044, 2011. [Journal: Article] [CI: 15] [IF: 12,6]
DOI: 10.1107/S090744491104491X SCOPUS: 82455198838
Buttachon S., Chandrapatya A., Manoch L., Silva A., Gales L., Bruyère C., Kiss R., Kijjoa A.
Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349). Tetrahedron68(15):3253-3262, 2012. [Journal: Article] [CI: 73] [IF: 2,8]
DOI: 10.1016/j.tet.2012.02.024 SCOPUS: 84858707940
Afonso R.V., Durão J., Mendes A., Damas A.M., Gales L.
Dipeptide crystals as excellent permselective materials: Sequential exclusion of argon, nitrogen, and oxygen. Angewandte Chemie - International Edition49(17):3034-3036, 2010. [Journal: Article] [CI: 61] [IF: 12,7]
DOI: 10.1002/anie.201000007 SCOPUS: 77951172416
Gales L., Cortes L., Almeida C., Melo C.V., Costa M.D.C., Maciel P., Clarke D.T., Damas A.M., Macedo-Ribeiro S.
Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: Trapping early oligomers of non-expanded ataxin-3. Journal of Molecular Biology353(3):642-654, 2005. [Journal: Article] [CI: 64] [IF: 5,2]
DOI: 10.1016/j.jmb.2005.08.061 SCOPUS: 26244434741
Gales L., Macedo-Ribeiro S., Arsequell G., Valencia G., Saraiva M.J., Damas A.M.
Human transthyretin in complex with iododiflunisal: Structural features associated with a potent amyloid inhibitor. Biochemical Journal388(2):615-621, 2005. [Journal: Article] [CI: 58] [IF: 4,2]
DOI: 10.1042/BJ20042035 SCOPUS: 20544432502
Durão J., Vale N., Gomes S., Gomes P., Barrias C.C., Gales L.
Nitric oxide release from antimicrobial peptide hydrogels for wound healing. Biomolecules9(1):, 2019. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.3390/biom9010004 SCOPUS: 85058910600
Afonso R., Mendes A., Gales L.
Peptide-based solids: Porosity and zeolitic behavior. Journal of Materials Chemistry22(5):1709-1723, 2012. [Journal: Review] [CI: 49] [IF: 6,1]
DOI: 10.1039/c1jm13568f SCOPUS: 84855666967
Metal-Organic Frameworks as Sensors for Human Amyloid Diseases. ACS Sensors8(3):1033-1053, 2023. [Journal: Review] [CI: 31] [IF: 8,9 (*)]
DOI: 10.1021/acssensors.2c02741 SCOPUS: 85149840593
Mendes R.F., Figueira F., Leite J.P., Gales L., Almeida Paz F.A.
Metal-organic frameworks: A future toolbox for biomedicine?. Chemical Society Reviews49(24):9121-9153, 2020. [Journal: Review] [CI: 169] [IF: 54,6]
DOI: 10.1039/d0cs00883d SCOPUS: 85097887408
Leite J., Mota R., Durão J., Neves S., Barrias C., Tamagnini P., Gales L.
Cyanobacterium-Derived Extracellular Carbohydrate Polymer for the Controlled Delivery of Functional Proteins. Macromolecular Bioscience17(2):, 2017. [Journal: Article] [CI: 20] [IF: 3,4]
DOI: 10.1002/mabi.201600206 SCOPUS: 84988663806
Castro-Rodrigues A., Gales L., Saraiva M., Damas A.
Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils. Acta Crystallographica Section D: Biological Crystallography67(12):1035-1044, 2011. [Journal: Article] [CI: 15] [IF: 12,6]
DOI: 10.1107/S090744491104491X SCOPUS: 82455198838
Buttachon S., Chandrapatya A., Manoch L., Silva A., Gales L., Bruyère C., Kiss R., Kijjoa A.
Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349). Tetrahedron68(15):3253-3262, 2012. [Journal: Article] [CI: 73] [IF: 2,8]
DOI: 10.1016/j.tet.2012.02.024 SCOPUS: 84858707940
Afonso R.V., Durão J., Mendes A., Damas A.M., Gales L.
Dipeptide crystals as excellent permselective materials: Sequential exclusion of argon, nitrogen, and oxygen. Angewandte Chemie - International Edition49(17):3034-3036, 2010. [Journal: Article] [CI: 61] [IF: 12,7]
DOI: 10.1002/anie.201000007 SCOPUS: 77951172416
Gales L., Cortes L., Almeida C., Melo C.V., Costa M.D.C., Maciel P., Clarke D.T., Damas A.M., Macedo-Ribeiro S.
Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: Trapping early oligomers of non-expanded ataxin-3. Journal of Molecular Biology353(3):642-654, 2005. [Journal: Article] [CI: 64] [IF: 5,2]
DOI: 10.1016/j.jmb.2005.08.061 SCOPUS: 26244434741
Gales L., Macedo-Ribeiro S., Arsequell G., Valencia G., Saraiva M.J., Damas A.M.
Human transthyretin in complex with iododiflunisal: Structural features associated with a potent amyloid inhibitor. Biochemical Journal388(2):615-621, 2005. [Journal: Article] [CI: 58] [IF: 4,2]
DOI: 10.1042/BJ20042035 SCOPUS: 20544432502
Durão J., Vale N., Gomes S., Gomes P., Barrias C.C., Gales L.
Nitric oxide release from antimicrobial peptide hydrogels for wound healing. Biomolecules9(1):, 2019. [Journal: Article] [CI: 31] [IF: 4,1]
DOI: 10.3390/biom9010004 SCOPUS: 85058910600
Afonso R., Mendes A., Gales L.
Peptide-based solids: Porosity and zeolitic behavior. Journal of Materials Chemistry22(5):1709-1723, 2012. [Journal: Review] [CI: 49] [IF: 6,1]
DOI: 10.1039/c1jm13568f SCOPUS: 84855666967