Where Ideas Grow
Marta V. Mendes
Junior Researcher
Marta V. Mendes (MVM) graduated in Biochemistry at the University of Lisbon in 1997 and in 2003, completed her PhD degree (cum laude) in Biological Sciences (Plant and Microbial Biotechnology) at the University of León (Spain). During the PhD she was responsible for the elucidation of the post-PKS biosynthetic steps of a polyene antibiotic. Her interest in the biosynthesis and regulation of specialized metabolites in Streptomyces continued during her two postdoctoral periods, first in Spain (Institute of Biotechnology of León) and then in France (Université Henry Poincaré), as a team member of a European FP6 funded project (ActinoGEN). In 2005, MVM returned to Portugal as a postdoctoral research fellow and since 2007, she has been able to continuously attract competitive funding (National and European) as principal investigator, focusing her research on the regulatory networks that control Streptomyces physiology and metabolism. Currently she is the coordinator of a joint ERA-IB-2 / ERASynBio research project (TACRODRUGS) that includes seven European partners. TACRODRUGS introduces the concept of a ?specialized? expression host for the production of high added-value products through the synergic use of synthetic biology principles and metabolic engineering methodologies.

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Selected Publications

Albuquerque P., Ribeiro I., Correia S., Mucha A.P., Tamagnini P., Braga-Henriques A., Carvalho M.d.F., Mendes M.V.,
Complete genome sequence of two deep-sea streptomyces isolates from madeira archipelago and evaluation of their biosynthetic potential. Marine Drugs19(11):, 2021. [Journal: Article] [CI: 4] [IF: 6,1]
DOI: 10.3390/md19110621 SCOPUS: 85118745441.

Oliveira R., Bush M.J., Pires S., Chandra G., Casas-Pastor D., Fritz G., Mendes M.V.,
The novel ECF56 SigG1-RsfG system modulates morphological differentiation and metal-ion homeostasis in Streptomyces tsukubaensis. Scientific Reports10(1):, 2020. [Journal: Article] [CI: 2] [IF: 4,4]
DOI: 10.1038/s41598-020-78520-x SCOPUS: 85097499901.

Marques F., Luzhetskyy A., Mendes M.V.,
Engineering Corynebacterium glutamicum with a comprehensive genomic library and phage-based vectors. Metabolic Engineering62:221-234, 2020. [Journal: Article] [CI: 4] [IF: 9,8]
DOI: 10.1016/j.ymben.2020.08.007 SCOPUS: 85091667230.

Pires S.D.S., Oliveira R., Moradas-ferreira P., Mendes M.V.,
The onset of tacrolimus biosynthesis in streptomyces tsukubaensis is dependent on the intracellular redox status. Antibiotics9(10):1-17, 2020. [Journal: Article] [CI: 5] [IF: 4,6]
DOI: 10.3390/antibiotics9100703 SCOPUS: 85092747862.

Beites T., Mendes M.V.,
Chassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolism. Frontiers in Microbiology6(SEP):, 2015. [Journal: Review] [CI: 31] [IF: 4,2]
DOI: 10.3389/fmicb.2015.00906 SCOPUS: 84946746207.

Beites T., Oliveira P., Rioseras B., Pires S.D.S., Oliveira R., Tamagnini P., Moradas-Ferreira P., Manteca Á., Mendes M.V.,
Streptomyces natalensis programmed cell death and morphological differentiation are dependent on oxidative stress. Scientific Reports5:, 2015. [Journal: Article] [CI: 24] [IF: 5,2]
DOI: 10.1038/srep12887 SCOPUS: 84939181682.

Horbal L., Marques F., Nadmid S., Mendes M.V., Luzhetskyy A.,
Secondary metabolites overproduction through transcriptional gene cluster refactoring. Metabolic Engineering49:299-315, 2018. [Journal: Article] [CI: 48] [IF: 7,8]
DOI: 10.1016/j.ymben.2018.09.010 SCOPUS: 85053808442.

Beites T., Rodríguez-García A., Moradas-Ferreira P., Aparicio J.F., Mendes M.V.,
Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species. Applied Microbiology and Biotechnology98(5):2231-2241, 2014. [Journal: Article] [CI: 11] [IF: 3,3]
DOI: 10.1007/s00253-013-5455-z SCOPUS: 84896737742.

Mendes M.V., Recio E., Antón N., Guerra S.M., Santos-Aberturas J., Martín J.F., Aparicio J.F.,
Cholesterol Oxidases Act as Signaling Proteins for the Biosynthesis of the Polyene Macrolide Pimaricin. Chemistry and Biology14(3):279-290, 2007. [Journal: Article] [CI: 58] [IF: 5,7]
DOI: 10.1016/j.chembiol.2007.01.010 SCOPUS: 33947265302.

Mendes M.V., Recio E., Fouces R., Luiten R., Martín J.F., Aparicio J.F.,
Engineered biosynthesis of novel polyenes: A pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis. Chemistry and Biology8(7):635-644, 2001. [Journal: Article] [CI: 94] [IF: 6]
DOI: 10.1016/S1074-5521(01)00033-3 SCOPUS: 0034945645.