Mónica Sousa
Nerve Regeneration
Group leader
Monica M Sousa graduated in Biochemistry and holds a PhD in Biomedical Sciences from the University of Porto. During her PhD she studied the biology of an aggregation-prone protein that induces axon degeneration. As a postdoctoral fellow, Monica worked at Columbia University- New York, where she studied signaling cascades mediating neurodegeneration caused by amyloid fibrils. Since 2008, Monica leads the Nerve Regeneration group at the IBMC/i3S. Her group is focused on understanding cytoskeleton organization and dynamics during axon growth, degeneration and regeneration. She is currently the director of the IBMC, one of the founder institutes of the i3S- University of Porto.
Selected Publications
Brites P., Sousa M.M.,
Nascimento A.I., Da Silva T.F., Fernandes E.C., Luz L.L., Mar F.M., Safronov B.V., Sousa M.M.,
Nogueira-Rodrigues J., Leite S.C., Pinto-Costa R., Sousa S.C., Luz L.L., Sintra M.A., Oliveira R., Monteiro A.C., Pinheiro G.G., Vitorino M., Silva J.A., Simão S., Fernandes V.E., Provazník J., Benes V., Cruz C.D., Safronov B.V., Magalhães A., Reis C.A., Vieira J., Vieira C.P., Tiscórnia G., Araújo I.M., Sousa M.M.,
Pinto-Costa R., Sousa S.C., Leite S.C., Nogueira-Rodrigues J., da Silva T.F., Machado D., Marques J., Costa A.C., Liz M.A., Bartolini F., Brites P., Costell M., Fässler R., Sousa M.M.,
Costa A.R., Sousa S.C., Pinto-Costa R., Mateus J.C., Lopes C.D.F., Costa A.C., Rosa D., Machado D., Pajuelo L., Wang X., Zhou F.Q., Pereira A.J., Sampaio P., Rubinstein B.Y., Pinto I.M., Lampe M., Aguiar P., Sousa M.M.,
Nascimento A.I., Mar F.M., Sousa M.M.,
Leite S.C., Sampaio P., Sousa V.F., Nogueira-Rodrigues J., Pinto-Costa R., Peters L.L., Brites P., Sousa M.M.,
Neurons contribute to pathology in a mouse model of Krabbe disease in a cellautonomous manner. PLoS Biology20(7):, 2022. [Journal: Article] [CI: 1] [IF: 9,8]
DOI: 10.1371/journal.pbio.3001706 SCOPUS: 85134360903.
DOI: 10.1371/journal.pbio.3001706 SCOPUS: 85134360903.
Nascimento A.I., Da Silva T.F., Fernandes E.C., Luz L.L., Mar F.M., Safronov B.V., Sousa M.M.,
Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain. Brain145(5):1632-1640, 2022. [Journal: Article] [CI: 7] [IF: 14,5]
DOI: 10.1093/brain/awac078 SCOPUS: 85131702538.
DOI: 10.1093/brain/awac078 SCOPUS: 85131702538.
Nogueira-Rodrigues J., Leite S.C., Pinto-Costa R., Sousa S.C., Luz L.L., Sintra M.A., Oliveira R., Monteiro A.C., Pinheiro G.G., Vitorino M., Silva J.A., Simão S., Fernandes V.E., Provazník J., Benes V., Cruz C.D., Safronov B.V., Magalhães A., Reis C.A., Vieira J., Vieira C.P., Tiscórnia G., Araújo I.M., Sousa M.M.,
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection. Developmental Cell57(4):440-450.e7, 2022. [Journal: Article] [CI: 19] [IF: 11,8]
DOI: 10.1016/j.devcel.2021.12.008 SCOPUS: 85123830565.
DOI: 10.1016/j.devcel.2021.12.008 SCOPUS: 85123830565.
Pinto-Costa R., Sousa S.C., Leite S.C., Nogueira-Rodrigues J., da Silva T.F., Machado D., Marques J., Costa A.C., Liz M.A., Bartolini F., Brites P., Costell M., Fässler R., Sousa M.M.,
Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration. Journal of Clinical Investigation130(4):2024-2040, 2020. [Journal: Article] [CI: 20] [IF: 14,8]
DOI: 10.1172/JCI125771 SCOPUS: 85082814702.
DOI: 10.1172/JCI125771 SCOPUS: 85082814702.
Costa A.R., Sousa S.C., Pinto-Costa R., Mateus J.C., Lopes C.D.F., Costa A.C., Rosa D., Machado D., Pajuelo L., Wang X., Zhou F.Q., Pereira A.J., Sampaio P., Rubinstein B.Y., Pinto I.M., Lampe M., Aguiar P., Sousa M.M.,
The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction. eLife9:, 2020. [Journal: Article] [CI: 37] [IF: 8,1]
DOI: 10.7554/eLife.55471 SCOPUS: 85082635132.
DOI: 10.7554/eLife.55471 SCOPUS: 85082635132.
Nascimento A.I., Mar F.M., Sousa M.M.,
The intriguing nature of dorsal root ganglion neurons: Linking structure with polarity and function. Progress in Neurobiology168:86-103, 2018. [Journal: Review] [CI: 69] [IF: 10,7]
DOI: 10.1016/j.pneurobio.2018.05.002 SCOPUS: 85048777484.
DOI: 10.1016/j.pneurobio.2018.05.002 SCOPUS: 85048777484.
Leite S.C., Sampaio P., Sousa V.F., Nogueira-Rodrigues J., Pinto-Costa R., Peters L.L., Brites P., Sousa M.M.,
The Actin-Binding Protein a-Adducin Is Required for Maintaining Axon Diameter. Cell Reports15(3):490-498, 2016. [Journal: Article] [CI: 76] [IF: 8,3]
DOI: 10.1016/j.celrep.2016.03.047 SCOPUS: 84962762309.
DOI: 10.1016/j.celrep.2016.03.047 SCOPUS: 84962762309.