Paula Ferreira
Immunobiology
Senior Researcher
Paula Ferreira received his PhD in Biomedical Sciences from Instituto de Ciências Biomédicas Abel Salazar by University of Porto (1997) where she became Associate Professor. Her research work aims at elucidating the mechanisms by which the two human pathogens, Streptococcus sobrinus that causes dental caries and Streptococcus agalactiae the leading agent of neonatal diseases (sepsis, pneumonia and meningitis,) interact with the immune system in order to survive in the host. This will lead to the development of new vaccines and the design of new therapeutic strategies against these human diseases. His scientific activity was distinguished with the prize Câmara Pestana (2005).
Selected Publications
Bonifácio Andrade E., Lorga I., Roque S., Geraldo R., Mesquita P., Castro R., Simões-Costa L., Costa M., Faustino A., Ribeiro A., Correia-Neves M., Trieu-Cuot P., Ferreira P.,
Magalhães C., Lima M., Trieu-Cuot P., Ferreira P.,
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.,
Andrade E.B., Alves J., Madureira P., Oliveira L., Ribeiro A., Cordeiro-Da-Silva A., Correia-Neves M., Trieu-Cuot P., Ferreira P.,
Magalhães V., Andrade E.B., Alves J., Ribeiro A., Kim K.S., Lima M., Trieu-Cuot P., Ferreira P.,
Oliveira L., Madureira P., Andrade E.B., Bouaboud A., Morello E., Ferreira P., Poyart C., Trieu-Cuot P., Dramsi S.,
Alves J., Madureira P., Baltazar M.T., Barros L., Oliveira L., Dinis-Oliveira R.J., Andrade E.B., Ribeiro A., Vieira L.M., Trieu-Cuot P., Duarte J.A., Carvalho F., Ferreira P.,
Madureira P., Andrade E.B., Gama B., Oliveira L., Moreira S., Ribeiro A., Correia-Neves M., Trieu-Cuot P., Vilanova M., Ferreira P.,
Maternal vaccination against group B Streptococcus glyceraldehyde-3-phosphate dehydrogenase leads to gut dysbiosis in the offspring. Brain, Behavior, and Immunity103:186-201, 2022. [Journal: Article] [CI: 3] [IF: 15,1]
DOI: 10.1016/j.bbi.2022.04.004 SCOPUS: 85129039791.
DOI: 10.1016/j.bbi.2022.04.004 SCOPUS: 85129039791.
Magalhães C., Lima M., Trieu-Cuot P., Ferreira P.,
To give or not to give antibiotics is not the only question. The Lancet Infectious Diseases21(7):e191-e201, 2021. [Journal: Review] [CI: 12] [IF: 71,4]
DOI: 10.1016/S1473-3099(20)30602-2 SCOPUS: 85099071889.
DOI: 10.1016/S1473-3099(20)30602-2 SCOPUS: 85099071889.
Andrade E.B., Magalhães A., Puga A., Costa M., Bravo J., Portugal C.C., Ribeiro A., Correia-Neves M., Faustino A., Firon A., Trieu-Cuot P., Summavielle T., Ferreira P.,
A mouse model reproducing the pathophysiology of neonatal groupαB streptococcal infection. Nature Communications9(1):, 2018. [Journal: Article] [CI: 41] [IF: 11,9]
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907.
DOI: 10.1038/s41467-018-05492-y SCOPUS: 85051277907.
Andrade E.B., Alves J., Madureira P., Oliveira L., Ribeiro A., Cordeiro-Da-Silva A., Correia-Neves M., Trieu-Cuot P., Ferreira P.,
TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. Journal of Immunology191(9):4759-4768, 2013. [Journal: Article] [CI: 51] [IF: 5,4]
DOI: 10.4049/jimmunol.1301752 SCOPUS: 84885983093.
DOI: 10.4049/jimmunol.1301752 SCOPUS: 84885983093.
Magalhães V., Andrade E.B., Alves J., Ribeiro A., Kim K.S., Lima M., Trieu-Cuot P., Ferreira P.,
Group B Streptococcus Hijacks the Host Plasminogen System to Promote Brain Endothelial Cell Invasion. PLoS ONE8(5):, 2013. [Journal: Article] [CI: 26] [IF: 3,5]
DOI: 10.1371/journal.pone.0063244 SCOPUS: 84877045471.
DOI: 10.1371/journal.pone.0063244 SCOPUS: 84877045471.
Oliveira L., Madureira P., Andrade E.B., Bouaboud A., Morello E., Ferreira P., Poyart C., Trieu-Cuot P., Dramsi S.,
Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages. PLoS ONE7(1):, 2012. [Journal: Article] [CI: 75] [IF: 3,7]
DOI: 10.1371/journal.pone.0029963 SCOPUS: 84856120822.
DOI: 10.1371/journal.pone.0029963 SCOPUS: 84856120822.
Alves J., Madureira P., Baltazar M.T., Barros L., Oliveira L., Dinis-Oliveira R.J., Andrade E.B., Ribeiro A., Vieira L.M., Trieu-Cuot P., Duarte J.A., Carvalho F., Ferreira P.,
A safe and stable neonatal vaccine targeting GAPDH confers protection against Group B Streptococcus infections in adult susceptible mice. PLoS ONE10(12):, 2015. [Journal: Article] [CI: 12] [IF: 3,1]
DOI: 10.1371/journal.pone.0144196 SCOPUS: 84956604014.
DOI: 10.1371/journal.pone.0144196 SCOPUS: 84956604014.
Madureira P., Andrade E.B., Gama B., Oliveira L., Moreira S., Ribeiro A., Correia-Neves M., Trieu-Cuot P., Vilanova M., Ferreira P.,
Inhibition of IL-10 production by maternal antibodies against group b streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment. PLoS Pathogens7(11):, 2011. [Journal: Article] [CI: 39] [IF: 9,1]
DOI: 10.1371/journal.ppat.1002363 SCOPUS: 81755177757.
DOI: 10.1371/journal.ppat.1002363 SCOPUS: 81755177757.