creating a
healthier future
Ana Xavier de Carvalho
Group leader
Ana Carvalho graduated in Biochemistry from the Faculty of Sciences of the University of Porto. She did her doctoral studies on mitosis with Prof. Bill Earnshaw at the Wellcome Trust Centre for Cell Biology in Edinburgh, UK. Her postdoctoral work focused on the study of cytokinesis and was carried out in Prof. Karen Oegema's group at the Ludwig Institute for Cancer Research in San Diego, USA. In 2012, she moved to the Institute for Molecular and Cell Biology in Porto as a Principal Investigator.

Selected Publications

Carvalho A., Desai A., Oegema K.,
Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size. Cell137(5):926-937, 2009. [Journal: Article] [CI: 162] [IF: 31,2]
DOI: 10.1016/j.cell.2009.03.021 SCOPUS: 65849336045.


Carvalho A., Olson S.K., Gutierrez E., Zhang K., Noble L.B., Zanin E., Desai A., Groisman A., Oegema K.,
Acute drug treatment in the early C. elegans embryo. PLoS ONE6(9):, 2011. [Journal: Article] [CI: 87] [IF: 4,1]
DOI: 10.1371/journal.pone.0024656 SCOPUS: 80052849441.


Lewellyn L., Carvalho A., Desai A., Maddox A.S., Oegema K.,
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. Journal of Cell Biology193(1):155-169, 2011. [Journal: Article] [CI: 53] [IF: 10,3]
DOI: 10.1083/jcb.201008138 SCOPUS: 79955513613.


Davies T., Jordan S.N., Chand V., Sees J.A., Laband K., Carvalho A.X., Shirasu-Hiza M., Kovar D.R., Dumont J., Canman J.C.,
High-Resolution Temporal Analysis Reveals a Functional Timeline for the Molecular Regulation of Cytokinesis. Developmental Cell30(2):209-223, 2014. [Journal: Article] [CI: 56] [IF: 9,7]
DOI: 10.1016/j.devcel.2014.05.009 SCOPUS: 84904886021.


Silva A.M., Osório D.S., Pereira A.J., Maiato H., Pinto I.M., Rubinstein B., Gassmann R., Telley I.A., Carvalho A.X.,
Robust gap repair in the contractile ring ensures timely completion of cytokinesis. Journal of Cell Biology215(6):789-799, 2016. [Journal: Article] [CI: 19] [IF: 8]
DOI: 10.1083/jcb.201605080 SCOPUS: 85009223214.


Chan F.Y., Silva A.M., Saramago J., Pereira-Sousa J., Brighton H.E., Pereira M., Oegema K., Gassmann R., Carvalho A.X.,
The ARP2/3 complex prevents excessive formin activity during cytokinesis. Molecular Biology of the Cell30(1):96-107, 2019. [Journal: Article] [CI: 28] [IF: 3,8]
DOI: 10.1091/mbc.E18-07-0471 SCOPUS: 85059257752.


Leite J., Osorio D.S., Sobral A.F., Silva A.M., Carvalho A.X.,
Network contractility during cytokinesis—from molecular to global views. Biomolecules9(5):, 2019. [Journal: Article] [CI: 17] [IF: 4,1]
DOI: 10.3390/biom9050194 SCOPUS: 85066454203.


Osório D.S., Chan F.Y., Saramago J., Leite J., Silva A.M., Sobral A.F., Gassmann R., Carvalho A.X.,
Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans. Development146(21):, 2019. [Journal: Article] [CI: 16] [IF: 5,6]
DOI: 10.1242/dev.179150 SCOPUS: 85074964249.


Leite J., Chan F.Y., Osório D.S., Saramago J., Sobral A.F., Silva A.M., Gassmann R., Carvalho A.X.,
Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-actin Bundles in the Cytokinetic Ring. Frontiers in Cell and Developmental Biology8:, 2020. [Journal: Article] [CI: 12] [IF: 6,7]
DOI: 10.3389/fcell.2020.573393 SCOPUS: 85092498962.


Sobral A.F., Chan F.Y., Norman M.J., Osório D.S., Dias A.B., Ferreira V., Barbosa D.J., Cheerambathur D., Gassmann R., Belmonte J.M., Carvalho A.X.,
Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis. Current Biology31(24):5415-5428.e10, 2021. [Journal: Article] [CI: 8] [IF: 10,9]
DOI: 10.1016/j.cub.2021.09.055 SCOPUS: 85121234178.