João Vinagre
Cancer Signalling & Metabolism
Associate Researcher
João Vinagre was born in Ovar, and graduated in Microbiology. He obtained is PhD degree in the University of Porto. He has published several scientific papers and has given lectured courses in PhD programmes. In 2013, he and his group published reference papers regarding novel molecular alterations of telomerase in several human cancers. As result of these publications he received an award for best work in genetics from the Portuguese Genetic Society. Additionally, he was awarded with the 2014 Pulido Valente prize from the Fundação para a Ciência e Tecnologia for the best published work from a Portuguese researcher.
Selected Publications
Melo M., Da Rocha A.G., Vinagre J., Sobrinho-Simões M., Soares P.
Coexistence of TERT promoter and BRAF mutations in papillary thyroid carcinoma: Added value in patient prognosis?. Journal of Clinical Oncology33(6):667-668, 2015. [Journal: Letter] [CI: 35] [IF: 21]
DOI: 10.1200/JCO.2014.59.4614 SCOPUS: 84923165572
Vinagre J., Almeida A., Pópulo H., Batista R., Lyra J., Pinto V., Coelho R., Celestino R., Prazeres H., Lima L., Melo M., Rocha A.G.D., Preto A., Castro P., Castro L., Pardal F., Lopes J.M., Santos L.L., Reis R.M., Cameselle-Teijeiro J., Sobrinho-Simões M., Lima J., Máximo V., Soares P.
Frequency of TERT promoter mutations in human cancers. Nature Communications4:, 2013. [Journal: Article] [CI: 713] [IF: 10,7]
DOI: 10.1038/ncomms3185 SCOPUS: 84884524540
Pópulo H., Boaventura P., Vinagre J., Batista R., Mendes A., Caldas R., Pardal J., Azevedo F., Honavar M., Guimarães I., Manuel Lopes J., Sobrinho-Simões M., Soares P.
TERT promoter mutations in skin cancer: The effects of sun exposure and X-irradiation. Journal of Investigative Dermatology134(8):2251-2257, 2014. [Journal: Article] [CI: 102] [IF: 7,2]
DOI: 10.1038/jid.2014.163 SCOPUS: 84904458479
Batista R., Cruvinel-Carloni A., Vinagre J., Peixoto J., Catarino T.A., Campanella N.C., Menezes W., Becker A.P., De Almeida G.C., Matsushita M.M., Clara C., Neder L., Viana-Pereira M., Honavar M., Castro L., Lopes J.M., Carvalho B., Vaz R.M., Máximo V., Soares P., Sobrinho-Simões M., Reis R.M., Lima J.
The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism. International Journal of Cancer139(2):414-423, 2016. [Journal: Article] [CI: 51] [IF: 6,5]
DOI: 10.1002/ijc.30057 SCOPUS: 84961644849
Melo M., Da Rocha A.G., Vinagre J., Batista R., Peixoto J., Tavares C., Celestino R., Almeida A., Salgado C., Eloy C., Castro P., Prazeres H., Lima J., Amaro T., Lobo C., Martins M.J., Moura M., Cavaco B., Leite V., Cameselle-Teijeiro J.M., Carrilho F., Carvalheiro M., Máximo V., Sobrinho-Simões M., Soares P.
TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism99(5):, 2014. [Journal: Article] [CI: 442] [IF: 6,2]
DOI: 10.1210/jc.2013-3734 SCOPUS: 84899908886
Melo M., Da Rocha A.G., Batista R., Vinagre J., Martins M.J., Costa G., Ribeiro C., Carrilho F., Leite V., Lobo C., Cameselle-Teijeiro J.M., Cavadas B., Pereira L., Sobrinho-Simoes M., Soares P.
TERT, BRAF, and NRAS in primary thyroid cancer and metastatic disease. Journal of Clinical Endocrinology and Metabolism102(6):1898-1907, 2017. [Journal: Article] [CI: 109] [IF: 5,8]
DOI: 10.1210/jc.2016-2785 SCOPUS: 85020422515
Prazeres H., Couto J.P., Rodrigues F., Vinagre J., Torres J., Trovisco V., Martins T.C., Sobrinho-Simões M., Soares P.
In vitro transforming potential, intracellular signaling properties, and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp. Endocrine-Related Cancer18(4):401-412, 2011. [Journal: Article] [CI: 10] [IF: 4,4]
DOI: 10.1530/ERC-10-0258 SCOPUS: 80052173114
Vinagre J., Nabais J., Pinheiro J., Batista R., Oliveira R.C., Gonçalves A.P., Pestana A., Reis M., Mesquita B., Pinto V., Lyra J., Cipriano M.A., Ferreira M.G., Lopes J.M., Sobrinho-Simões M., Soares P.
TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes. Scientific Reports6:, 2016. [Journal: Article] [CI: 13] [IF: 4,3]
DOI: 10.1038/srep29714 SCOPUS: 84978645289
Pestana A., Vinagre J., Sobrinho-Simões M., Soares P.
TERT biology and function in cancer: Beyond immortalisation. Journal of Molecular Endocrinology58(2):R129-R146, 2017. [Journal: Review] [CI: 72] [IF: 3,3]
DOI: 10.1530/JME-16-0195 SCOPUS: 85012146716
Amorim J.P., Santos G., Vinagre J., Soares P.
The role of ATRX in the alternative lengthening of telomeres (ALT) phenotype. Genes7(9):, 2016. [Journal: Review] [CI: 69] [IF: 3,6]
DOI: 10.3390/genes7090066 SCOPUS: 84989361040
Coexistence of TERT promoter and BRAF mutations in papillary thyroid carcinoma: Added value in patient prognosis?. Journal of Clinical Oncology33(6):667-668, 2015. [Journal: Letter] [CI: 35] [IF: 21]
DOI: 10.1200/JCO.2014.59.4614 SCOPUS: 84923165572
Vinagre J., Almeida A., Pópulo H., Batista R., Lyra J., Pinto V., Coelho R., Celestino R., Prazeres H., Lima L., Melo M., Rocha A.G.D., Preto A., Castro P., Castro L., Pardal F., Lopes J.M., Santos L.L., Reis R.M., Cameselle-Teijeiro J., Sobrinho-Simões M., Lima J., Máximo V., Soares P.
Frequency of TERT promoter mutations in human cancers. Nature Communications4:, 2013. [Journal: Article] [CI: 713] [IF: 10,7]
DOI: 10.1038/ncomms3185 SCOPUS: 84884524540
Pópulo H., Boaventura P., Vinagre J., Batista R., Mendes A., Caldas R., Pardal J., Azevedo F., Honavar M., Guimarães I., Manuel Lopes J., Sobrinho-Simões M., Soares P.
TERT promoter mutations in skin cancer: The effects of sun exposure and X-irradiation. Journal of Investigative Dermatology134(8):2251-2257, 2014. [Journal: Article] [CI: 102] [IF: 7,2]
DOI: 10.1038/jid.2014.163 SCOPUS: 84904458479
Batista R., Cruvinel-Carloni A., Vinagre J., Peixoto J., Catarino T.A., Campanella N.C., Menezes W., Becker A.P., De Almeida G.C., Matsushita M.M., Clara C., Neder L., Viana-Pereira M., Honavar M., Castro L., Lopes J.M., Carvalho B., Vaz R.M., Máximo V., Soares P., Sobrinho-Simões M., Reis R.M., Lima J.
The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism. International Journal of Cancer139(2):414-423, 2016. [Journal: Article] [CI: 51] [IF: 6,5]
DOI: 10.1002/ijc.30057 SCOPUS: 84961644849
Melo M., Da Rocha A.G., Vinagre J., Batista R., Peixoto J., Tavares C., Celestino R., Almeida A., Salgado C., Eloy C., Castro P., Prazeres H., Lima J., Amaro T., Lobo C., Martins M.J., Moura M., Cavaco B., Leite V., Cameselle-Teijeiro J.M., Carrilho F., Carvalheiro M., Máximo V., Sobrinho-Simões M., Soares P.
TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism99(5):, 2014. [Journal: Article] [CI: 442] [IF: 6,2]
DOI: 10.1210/jc.2013-3734 SCOPUS: 84899908886
Melo M., Da Rocha A.G., Batista R., Vinagre J., Martins M.J., Costa G., Ribeiro C., Carrilho F., Leite V., Lobo C., Cameselle-Teijeiro J.M., Cavadas B., Pereira L., Sobrinho-Simoes M., Soares P.
TERT, BRAF, and NRAS in primary thyroid cancer and metastatic disease. Journal of Clinical Endocrinology and Metabolism102(6):1898-1907, 2017. [Journal: Article] [CI: 109] [IF: 5,8]
DOI: 10.1210/jc.2016-2785 SCOPUS: 85020422515
Prazeres H., Couto J.P., Rodrigues F., Vinagre J., Torres J., Trovisco V., Martins T.C., Sobrinho-Simões M., Soares P.
In vitro transforming potential, intracellular signaling properties, and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp. Endocrine-Related Cancer18(4):401-412, 2011. [Journal: Article] [CI: 10] [IF: 4,4]
DOI: 10.1530/ERC-10-0258 SCOPUS: 80052173114
Vinagre J., Nabais J., Pinheiro J., Batista R., Oliveira R.C., Gonçalves A.P., Pestana A., Reis M., Mesquita B., Pinto V., Lyra J., Cipriano M.A., Ferreira M.G., Lopes J.M., Sobrinho-Simões M., Soares P.
TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes. Scientific Reports6:, 2016. [Journal: Article] [CI: 13] [IF: 4,3]
DOI: 10.1038/srep29714 SCOPUS: 84978645289
Pestana A., Vinagre J., Sobrinho-Simões M., Soares P.
TERT biology and function in cancer: Beyond immortalisation. Journal of Molecular Endocrinology58(2):R129-R146, 2017. [Journal: Review] [CI: 72] [IF: 3,3]
DOI: 10.1530/JME-16-0195 SCOPUS: 85012146716
Amorim J.P., Santos G., Vinagre J., Soares P.
The role of ATRX in the alternative lengthening of telomeres (ALT) phenotype. Genes7(9):, 2016. [Journal: Review] [CI: 69] [IF: 3,6]
DOI: 10.3390/genes7090066 SCOPUS: 84989361040