Where Ideas grow
Bruno Sarmento
Group leader

Bruno Sarmento is Principal Investigator at Institute for Research and Innovation in Health (i3S), University of Porto (UP), and Assistant Professor at Instituto Universitário de Ciências da Saúde (IUCS), Portugal. He graduated in Pharmaceutical Sciences at the University of Porto (PT) in 2002 and completed a PhD in Pharmaceutical Nanotechnology at UP in 2007, in collaboration with Queen’s University (CA), University of Copenhagen (DK) and University of Santiago de Compostela (ES). From 2007 to 2012 he held a Post-Doc position at UP, in collaboration with the University of Copenhagen. In 2008 he was appointed Assistant Professor at IUCS. He also co-founded Inovapotek in 2008, and is member of its advisory board. In 2012 he became Associated Researcher at i3S, where established an independent team. He was appointed as Assistant Researched at i3S in 2016, Principal Investigator in 2019 and member of the Board of Directors in 2019. He is Visiting Professor at UniOeste (BR) and Visiting Research Professor at Queen’s University, Belfast (UK).

So far, he has supervised/co-supervised 14 Post-Docs (11 completed), 44 PhD students (28 completed) and 37 MSc students (35 completed), and 13 researcher assistants. He attracted direct competitive funding worth more than 10 M€, at national and international levels. His current research is focused on the development of functionalized nanomedicines and their application in the pharmaceutical and biomedical fields. In particular, nanoformulations of biopharmaceutical drugs with interest in diabetes, cancer and infectious diseases. He has also specialized in mucosal tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He published more than 360 papers in international peer reviewed (ISI) journals, most in top journals (Q1 in Pharmaceutical Sciences; Q1 in Nanoscience and Nanotechnology; total citations in Scopus 11000; H-index 52 and in GoogleScholar 15060; H-index 61), 54 book chapters and more than 300 proceedings. He edited 5 books, participated in more than 50 invited/selected talks in national and international meetings and was awarded several distinctions. He is editor of European Journal of Pharmaceutical Sciences, and member of the Editorial Advisory Board of several international journals, including the Journal of Controlled Release, Expert Opinion on Drug Delivery and Pharmaceutics. He has acted as referee for top-ranked journals in his area of expertise, and for international funding agencies: FNRS (BE), ESF, ANR (FR), CNCS (RO), FCT (PT), FNRS (BE), Foncyt (ARG), CNPq (BR) and European Commission.

In addition to being a partner in several research projects, he was the PI of competitively funded projects (FCT, Gilead and CESPU), PI of different bilateral collaborative projects between Portugal (FCT) and foreigner funding agencies as well as partner of several European projects funded by European Commission.

Bruno Sarmento was the first Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society.

Selected Publications

Bauleth-Ramos T., Feijão T., Gonçalves A., Shahbazi M.A., Liu Z., Barrias C., Oliveira M.J., Granja P., Santos H.A., Sarmento B.,
Colorectal cancer triple co-culture spheroid model to assess the biocompatibility and anticancer properties of polymeric nanoparticles. Journal of Controlled Release323:398-411, 2020. [Journal: Article] [CI: 6] [IF: 7,7 (*)]
DOI: 10.1016/j.jconrel.2020.04.025 SCOPUS: 85084193413.

Leong H.S., Butler K.S., Brinker C.J., Azzawi M., Conlan S., Dufés C., Owen A., Rannard S., Scott C., Chen C., Dobrovolskaia M.A., Kozlov S.V., Prina-Mello A., Schmid R., Wick P., Caputo F., Boisseau P., Crist R.M., McNeil S.E., Fadeel B., Tran L., Hansen S.F., Hartmann N.B., Clausen L.P.W., Skjolding L.M., Baun A., Ågerstrand M., Gu Z., Lamprou D.A., Hoskins C., Huang L., Song W., Cao H., Liu X., Jandt K.D., Jiang W., Kim B.Y.S., Wheeler K.E., Chetwynd A.J., Lynch I., Moghimi S.M., Nel A., Xia T., Weiss P.S., Sarmento B., das Neves J., Santos H.A., Santos L., Mitragotri S., Little S., Peer D., Amiji M.M., Alonso M.J., Petri-Fink A., Balog S., Lee A., Drasler B., Rothen-Rutishauser B., Wilhelm S., Acar H., Harrison R.G., Mao C., Mukherjee P., Ramesh R., McNally L.R., Busatto S., Wolfram J., Bergese P., Ferrari M., Fang R.H., Zhang L., Zheng J., Peng C., Du B., Yu M., Charron D.M., Zheng G., Pastore C.,
On the issue of transparency and reproducibility in nanomedicine. Nature Nanotechnology14(7):629-635, 2019. [Journal: Letter] [CI: 56] [IF: 31,5]
DOI: 10.1038/s41565-019-0496-9 SCOPUS: 85069268486.

Lin K., Zhang D., Macedo M.H., Cui W., Sarmento B., Shen G.,
Advanced Collagen-Based Biomaterials for Regenerative Biomedicine. Advanced Functional Materials29(3):, 2019. [Journal: Review] [CI: 55] [IF: 16,8]
DOI: 10.1002/adfm.201804943 SCOPUS: 85057216174.

Costa A., de Souza Carvalho-Wodarz C., Seabra V., Sarmento B., Lehr C.M.,
Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier. Acta Biomaterialia91:235-247, 2019. [Journal: Article] [CI: 10] [IF: 7,2]
DOI: 10.1016/j.actbio.2019.04.037 SCOPUS: 85064521323.

Sousa F., Dhaliwal H.K., Gattacceca F., Sarmento B., Amiji M.M.,
Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles. Journal of Controlled Release309:37-47, 2019. [Journal: Article] [CI: 18] [IF: 7,7]
DOI: 10.1016/j.jconrel.2019.07.033 SCOPUS: 85069705484.

Bauleth-Ramos T., Shih T.Y., Shahbazi M.A., Najibi A.J., Mao A.S., Liu D., Granja P., Santos H.A., Sarmento B., Mooney D.J.,
Acetalated Dextran Nanoparticles Loaded into an Injectable Alginate Cryogel for Combined Chemotherapy and Cancer Vaccination. Advanced Functional Materials29(35):, 2019. [Journal: Article] [CI: 10] [IF: 16,8]
DOI: 10.1002/adfm.201903686 SCOPUS: 85068179169.

Lechanteur A., das Neves J., Sarmento B.,
The role of mucus in cell-based models used to screen mucosal drug delivery. Advanced Drug Delivery Reviews124:50-63, 2018. [Journal: Review] [CI: 36] [IF: 15,5]
DOI: 10.1016/j.addr.2017.07.019 SCOPUS: 85026524492.

Araújo F., das Neves J., Martins J.P., Granja P.L., Santos H.A., Sarmento B.,
Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals. Progress in Materials Science89:306-344, 2017. [Journal: Review] [CI: 19] [IF: 23,8]
DOI: 10.1016/j.pmatsci.2017.05.001 SCOPUS: 85020029869.

Azevedo C., Nilsen J., Grevys A., Nunes R., Andersen J.T., Sarmento B.,
Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin. Journal of Controlled Release327:161-173, 2020. [Journal: Article] [CI: 4] [IF: 7,7 (*)]
DOI: 10.1016/j.jconrel.2020.08.005 SCOPUS: 85089361328.

Andrade F., Rafael D., Vilar-Hernández M., Montero S., Martínez-Trucharte F., Seras-Franzoso J., Díaz-Riascos Z.V., Boullosa A., García-Aranda N., Cámara-Sánchez P., Arango D., Nestor M., Abasolo I., Sarmento B., Schwartz S.,
Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo. Journal of Controlled Release331:198-212, 2021. [Journal: Article] [IF: 7,7 (*)]
DOI: 10.1016/j.jconrel.2021.01.022 SCOPUS: 85099694621.