creating a
healthier future
Rute Nunes
Associate Researcher

Rute Nunes is currently an Associate Researcher at Nanomedicines & Translational Drug Delivery Group at Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Portugal and an Invited Assistant Professor at Instituto Universitário de Ciências da Saúde (IUCS), Gandra, Portugal. She graduated in Pharmaceutical Sciences in 2013 and holds a PhD in Biomedical Sciences (2018) from Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), University of Porto, Portugal in collaboration with Instituto de Investigação do Medicamento (iMEd.ULisboa), Faculdade de Farmácia, Universidade de Lisboa. Her research is focused on the development of nanotechnology-based drug delivery systems for mucosal drug delivery. In the last two years, she also conducted research in the cell replacement therapy field, focusing in the combination of stem cell-based therapies and smart nanomedicines for Type 1 Diabetes Mellitus treatment. Her broad research interests include nanomedicine, nanotechnology-based systems for drug delivery, biomaterials and cell-based therapies. She has a broad experience in the development and characterization of polymeric nanosystems, cell-based assays and in vivo experiments using healthy and diseased animal models. She published 23 papers in international peer reviewed (ISI) journals and four book chapters with a h-index of 16 and a total of 574 citations. She interacted with 78 collaborators co-authorship of scientific work. As a researcher, she describes herself as a passionate and versatile researcher, capable of integrating different projects, being highly adaptable to different situations and challenges. Besides being a dedicated worker, she is always enthusiastic to learn and develop new skills.

Selected Publications

Sadio A., Amaral A.L., Nunes R., Ricardo S., Sarmento B., Almeida R., Tsukamoto H., das Neves J.,
A mouse intra-intestinal infusion model and its application to the study of nanoparticle distribution. Frontiers in Physiology7(NOV):, 2016. [Journal: Article] [CI: 8] [IF: 4,1]
DOI: 10.3389/fphys.2016.00579 SCOPUS: 85006371437.

das Neves J., Nunes R., Rodrigues F., Sarmento B.,
Nanomedicine in the development of anti-HIV microbicides. Advanced Drug Delivery Reviews103:57-75, 2016. [Journal: Review] [CI: 47] [IF: 11,8]
DOI: 10.1016/j.addr.2016.01.017 SCOPUS: 84957927659.

Cunha-Reis C., Machado A., Barreiros L., Araújo F., Nunes R., Seabra V., Ferreira D., Segundo M.A., Sarmento B., das Neves J.,
Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs. Journal of Controlled Release243:43-53, 2016. [Journal: Article] [CI: 77] [IF: 7,8]
DOI: 10.1016/j.jconrel.2016.09.020 SCOPUS: 84990849820.

Machado A., Cunha-Reis C., Araújo F., Nunes R., Seabra V., Ferreira D., das Neves J., Sarmento B.,
Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system. Acta Biomaterialia44:332-340, 2016. [Journal: Article] [CI: 59] [IF: 6,3]
DOI: 10.1016/j.actbio.2016.08.018 SCOPUS: 84992121833.

das Neves J., Nunes R., Machado A., Sarmento B.,
Polymer-based nanocarriers for vaginal drug delivery. Advanced Drug Delivery Reviews92:53-70, 2015. [Journal: Review] [CI: 95] [IF: 15,6]
DOI: 10.1016/j.addr.2014.12.004 SCOPUS: 84943453074.

Nunes R., Sarmento B., Das Neves J.,
Formulation and delivery of anti-HIV rectal microbicides: Advances and challenges. Journal of Controlled Release194:278-294, 2014. [Journal: Review] [CI: 37] [IF: 7,7]
DOI: 10.1016/j.jconrel.2014.09.013 SCOPUS: 84907681124.

Nunes R., Araújo F., Barreiros L., Bártolo I., Segundo M.A., Taveira N., Sarmento B., Das Neves J.,
Noncovalent PEG Coating of Nanoparticle Drug Carriers Improves the Local Pharmacokinetics of Rectal Anti-HIV Microbicides. ACS Applied Materials and Interfaces10(41):34942-34953, 2018. [Journal: Article] [CI: 28] [IF: 8,5]
DOI: 10.1021/acsami.8b12214 SCOPUS: 85054761997.

Melo M., Nunes R., Sarmento B., das Neves J.,
Rectal administration of nanosystems: from drug delivery to diagnostics. Materials Today Chemistry10:128-141, 2018. [Journal: Review] [CI: 21]
DOI: 10.1016/j.mtchem.2018.09.001 SCOPUS: 85054189776.

Nunes R., Araújo F., Tavares J., Sarmento B., das Neves J.,
Surface modification with polyethylene glycol enhances colorectal distribution and retention of nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics130:200-206, 2018. [Journal: Article] [CI: 21] [IF: 4,7]
DOI: 10.1016/j.ejpb.2018.06.029 SCOPUS: 85049465651.

Mesquita L., Galante J., Nunes R., Sarmento B., Neves J.D.,
Pharmaceutical vehicles for vaginal and rectal administration of anti-hivmicrobicide nanosystems. Pharmaceutics11(3):, 2019. [Journal: Review] [CI: 23] [IF: 4,4]
DOI: 10.3390/pharmaceutics11030145 SCOPUS: 85064733632.