creating a
healthier future
Elsa Logarinho
Group leader

E. Logarinho concluded her PhD in Biomedical Sciences by the University of Porto (UP) in 2002. Under supervision of C.E. Sunkel at IBMC/UP, and short-term rotations at C. González lab/EMBL, she studied the Polo/Plk1 and BubR1 mitotic kinases in Drosophila, originally reporting Polo localization at kinetochores (J Cell Sci 1998) and that distinct mitotic checkpoint proteins respond differently to microtubule occupancy at kinetochores (J Cell Sci 2004). After her PhD, E. Logarinho pursued an academic path as full-time Assistant Professor, first at ISCS-N/CESPU (2002-2007) and then at Medical School/University of Minho (2007-2009). During this period, she co-authored 9 papers in different scientific areas (Mitosis, Machado-Joseph disease and infection) (2007- 2011). In 2009, E. Logarinho changed to a full-time research path under the ‘Ciência 2008’ program, joining H. Maiato lab at IBMC. Her work on mechanisms ensuring mitotic spindle-pole integrity (Nat Cell Biol 2012, 2014) was acknowledged with the Pfizer 2011 and SPGH 2013 prestigious national prizes. In 2013, she was awarded a Junior Researcher position funded by ON.2/QREN/FEDER to launch innovative research lines at IBMC (now part of the i3S Consortium/UP). In 2015, she was highly recommended by the IBMC External Advisory Board for an independent research group status, and simultaneously awarded with an FCT Investigator competitive grant.

Since 2017, E. Logarinho is the director of the Ageing and Aneuploidy group at i3S dedicated to high-profile research on the intricate link between aneuploidy and ageing hallmarks. Using cellular and animal models of natural and accelerated ageing, such as the Hutchinson-Gilford and Down syndromes, novel molecular targets whose modulation restores genome stability and delays senescence have been identified. Selected publications in the last 5 years include Nat Communics 2018, Embo Rep 2020, Cell Death Dis 2021 and Nat Aging 2022. The originality of her work has caught international recognition as illustrated by theMaximon Longevity Prize 2022, the strong collaborative network and track record, the delivery of invited talks in prestigious conferences, the evaluation of international grants as expert, invited reviews, and co-chairing of a Forbeck forum in Cancer. As a PI, E. Logarinho secured >2.5M€ competitive funding (4 FCT national grants; Work package leader in 3 institutional grants Norte2020/Portugal2020; 1 grant from Progeria Research Foundation; 1 grant from Jeróme Lejeune Foundation; 1 grant from Compete 2020/Portugal2020 in co-promotion with Insparya company), 2 CEEC postdoctoral positions (>700k€) and 7 PhD fellowships (>900k€). Besides her core scientific activities, E. Logarinho is regularly invited for UP meetings, doctoral programs and workshops, MSc/PhD theses exams, and actively involved in outreach activities. She is also a Research Consultant at the Insparya Hair Company. E. Logarinho co-authored a total of 43 publications (20 as main author, first or last) with over 2300 citations and an h-index of 25 (Google Scholar).

Selected Publications

Ribeiro R., Macedo J.C., Costa M., Ustiyan V., Shindyapina A.V., Tyshkovskiy A., Gomes R.N., Castro J.P., Kalin T.V., Vasques-Nóvoa F., Nascimento D.S., Dmitriev S.E., Gladyshev V.N., Kalinichenko V.V., Logarinho E.,
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. Nature Aging2(5):397-411, 2022. [Journal: Article] [CI: 18] [IF: 16,6]
DOI: 10.1038/s43587-022-00209-9 SCOPUS: 85129373440.

Ferreira F.J., Carvalho L., Logarinho E., Bessa J.,
Foxm1 modulates cell non-autonomous response in zebrafish skeletal muscle homeostasis. Cells10(5):, 2021. [Journal: Article] [CI: 6] [IF: 7,7]
DOI: 10.3390/cells10051241 SCOPUS: 85107456993.

Vaz S., Ferreira F.J., Macedo J.C., Leor G., Ben-David U., Bessa J., Logarinho E.,
FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell Death and Disease12(6):, 2021. [Journal: Article] [CI: 9] [IF: 9,7]
DOI: 10.1038/s41419-021-03822-5 SCOPUS: 85106857863.

Barroso-Vilares M., Macedo J.C., Reis M., Warren J.D., Compton D., Logarinho E.,
Small-molecule inhibition of aging-associated chromosomal instability delays cellular senescence. EMBO Reports21(5):, 2020. [Journal: Article] [CI: 22] [IF: 8,8]
DOI: 10.15252/embr.201949248 SCOPUS: 85081638234.

Castro A.R., Logarinho E.,
Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?. Stem Cells Translational Medicine9(3):342-350, 2020. [Journal: Review] [CI: 39] [IF: 6,9]
DOI: 10.1002/sctm.19-0301 SCOPUS: 85077400848.

Pereira S.M., Ribeiro R., Logarinho E.,
Approaches towards longevity: Reprogramming, senolysis, and improved mitotic competence as anti-aging therapies. International Journal of Molecular Sciences20(4):, 2019. [Journal: Review] [CI: 19] [IF: 4,6]
DOI: 10.3390/ijms20040938 SCOPUS: 85062013237.

Barroso-Vilares M., Logarinho E.,
Chromosomal instability and pro-inflammatory response in aging. Mechanisms of Ageing and Development182:, 2019. [Journal: Review] [CI: 18] [IF: 4,3]
DOI: 10.1016/j.mad.2019.111118 SCOPUS: 85065928704.

Pinho M., Macedo J.C., Logarinho E., Pereira P.S.,
NoL12 repression induces nucleolar stress-driven cellular senescence and is associated with normative aging. Molecular and Cellular Biology39(12):, 2019. [Journal: Article] [CI: 8] [IF: 3,6]
DOI: 10.1128/MCB.00099-19 SCOPUS: 85066485467.

Macedo J.C., Vaz S., Bakker B., Ribeiro R., Bakker P.L., Escandell J.M., Ferreira M.G., Medema R., Foijer F., Logarinho E.,
FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nature Communications9(1):, 2018. [Journal: Article] [CI: 75] [IF: 11,9]
DOI: 10.1038/s41467-018-05258-6 SCOPUS: 85050593345.

Nicholson J.M., Macedo J.C., Mattingly A.J., Wangsa D., Camps J., Lima V., Gomes A.M., Dória S., Ried T., Logarinho E., Cimini D.,
Chromosome mis-segregation and cytokinesis failure in trisomic human cells. eLife4(MAY):, 2015. [Journal: Article] [CI: 75] [IF: 8,3]
DOI: 10.7554/eLife.05068 SCOPUS: 84930649727.