Where Ideas grow
Elsa Logarinho
Cancer Program vice-coordinator

E. Logarinho concluded her PhD in Biomedical Sciences by the University of Porto (UP) in 2002. Under supervision of C.E. Sunkel at IBMC/UP, she studied the Polo/Plk1 and BubR1 mitotic kinases in Drosophila. After her PhD, E. Logarinho embraced a teaching position at the ISCS-N/CESPU Health Sciences School, while maintaining her research affiliation at IBMC. In 2007, E. Logarinho joined the Medical School/ICVS/UMinho as full-time Assistant Professor, and pursued her research in Mitosis, as well as contributed to several publications in other scientific areas. In 2009, E. Logarinho declined her professorship position and returned to full-time research career path under Ciência 2008 program, joining H. Maiato group at IBMC. Her work on mechanisms ensuring mitotic spindle-pole integrity (Nat Cell Biol 2012, 1st author) was acknowledged with an invited review in Nat Cell Biol 2014 (co-senior author) and Pfizer 2011 and SPGH 2013 prestigious national prizes.

In July 2013, she was awarded a Junior Researcher position funded by ON.2/QREN/FEDER to launch innovative research lines at IBMC (now part of the i3S Consortium/UP). Following a 2-year assessment period, she was highly recommended by the IBMC External Advisory Board for an independent research group status, and simultaneously awarded with a 5-year FCT Assistant Researcher position. Currently, her research group Aging & Aneuploidy is composed of 3 Post-Docs (started 2016, 2018, 2019) and 4 PhD students awarded with FCT fellowships (started 2016, 2017, 2018), working on to decipher mechanisms of mitotic dysfunction and aneuploidy contributing to aging and age-related diseases. Selected publications, out of 7 in the last 5 years with an average IF of 8.3, include as co-senior/senior author: Nat Cell Biol, Elife and Nat Commun. She successfully secured funding, presently coordinating 2 FCT projects and 2 tasks in a project granted to the Cancer Integrative Program of i3S (NORTE 2020). The originality of her work has caught international recognition shown by key international collaborations, the delivery of invited speaker/selected talks in prestigious meetings, peer reviewing and commissions of trust. She also collaborates with different groups at i3S, bridging Aging with all Integrative Programs. Besides her core scientific activities, E. Logarinho is regularly invited for UP meetings, doctoral programs and workshops, MSc/PhD theses exams, and actively involved in outreach activities. E. Logarinho h-index is of 17 (Scopus) as she co-authored 27 publications with 966 citations, including major multidisciplinary scientific journals.

Selected Publications

Pereira S.M., Ribeiro R., Logarinho E.,
Approaches towards longevity: Reprogramming, senolysis, and improved mitotic competence as anti-aging therapies. International Journal of Molecular Sciences20(4):, 2019. [Journal: Review] [CI: 7] [IF: 4,6]
DOI: 10.3390/ijms20040938 SCOPUS: 85062013237.

Macedo J.C., Vaz S., Bakker B., Ribeiro R., Bakker P.L., Escandell J.M., Ferreira M.G., Medema R., Foijer F., Logarinho E.,
FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nature Communications9(1):, 2018. [Journal: Article] [CI: 25] [IF: 11,9]
DOI: 10.1038/s41467-018-05258-6 SCOPUS: 85050593345.

Macedo J.C., Vaz S., Logarinho E.,
Mitotic dysfunction associated with aging hallmarks. Advances in Experimental Medicine and Biology1002:153-188, 2017. [Book Series: Chapter] [CI: 15] [IF: 1,8]
DOI: 10.1007/978-3-319-57127-0_7 SCOPUS: 85020653311.

Maiato H., Logarinho E.,
Mitotic spindle multipolarity without centrosome amplification. Nature Cell Biology16(5):386-394, 2014. [Journal: Review] [CI: 81] [IF: 19,7]
DOI: 10.1038/ncb2958 SCOPUS: 84899790283.

Logarinho E., Maffini S., Barisic M., Marques A., Toso A., Meraldi P., Maiato H.,
CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment. Nature Cell Biology14(3):295-303, 2012. [Journal: Article] [CI: 58] [IF: 20,8]
DOI: 10.1038/ncb2423 SCOPUS: 84857786388.

Rutledge S.D., Douglas T.A., Nicholson J.M., Vila-Casadesús M., Kantzler C.L., Wangsa D., Barroso-Vilares M., Kale S.D., Logarinho E., Cimini D.,
Selective advantage of trisomic human cells cultured in non-standard conditions. Scientific Reports6:, 2016. [Journal: Article] [CI: 37] [IF: 4,3]
DOI: 10.1038/srep22828 SCOPUS: 84959009777.

Nicholson J.M., Macedo J.C., Mattingly A.J., Wangsa D., Camps J., Lima V., Gomes A.M., Dória S., Ried T., Logarinho E., Cimini D.,
Chromosome mis-segregation and cytokinesis failure in trisomic human cells. eLife4(MAY):, 2015. [Journal: Article] [CI: 50] [IF: 8,3]
DOI: 10.7554/eLife.05068 SCOPUS: 84930649727.

Neves-Carvalho A., Logarinho E., Freitas A., Duarte-Silva S., do Carmo Costa M., Silva-Fernandes A., Martins M., Serra S.C., Lopes A.T., Paulson H.L., Heutink P., Relvas J.B., Maciel P.,
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells. Human Molecular Genetics24(1):100-117, 2015. [Journal: Article] [CI: 12] [IF: 6]
DOI: 10.1093/hmg/ddu422 SCOPUS: 84922522627.

Logarinho E., Resende T., Torres C., Bousbaa H.,
The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. Molecular Biology of the Cell19(4):1798-1813, 2008. [Journal: Article] [CI: 63] [IF: 5,6]
DOI: 10.1091/mbc.E07-07-0633 SCOPUS: 44949185572.

Logarinho E., Bousbaa H., Dias J.M., Lopes C., Amorim I., Antunes-Martins A., Sunkel C.E.,
Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells. Journal of Cell Science117(9):1757-1771, 2004. [Journal: Article] [CI: 88] [IF: 6,9]
DOI: 10.1242/jcs.01033 SCOPUS: 2342429609.