Carlos Conde
Cell Division & Genomic Stability
Associate Researcher
Carlos Conde (CC) is an Associate Researcher at i3S – Instituto de Investigação e Inovação em Saúde since 2015. He addresses fundamental questions on genome partitioning in order to understand why it fails so frequently in cancer. CC is focused on understanding the mechanisms underlying centromere structure, kinetochore-microtubule interactions and spindle assembly checkpoint signalling (SAC) and how defects in these processes impact on chromosomal instability (CIN) and tumorigenesis. To tackle these questions, CC combines in vitro biochemical and structural studies with functional analysis in human cells and Drosophila tissues.
Selected Publications
Barbosa J., Sunkel C.E., Conde C.
SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN. Journal of Cell Biology221(11):, 2022. [Journal: Article] [CI: 1] [IF: 7,8]
DOI: 10.1083/jcb.202209063 SCOPUS: 85139360830
Barbosa J., Sunkel C.E., Conde C.
The Role of Mitotic Kinases and the RZZ Complex in Kinetochore-Microtubule Attachments: Doing the Right Link. Frontiers in Cell and Developmental Biology10:, 2022. [Journal: Review] [CI: 7] [IF: 5,5]
DOI: 10.3389/fcell.2022.787294 SCOPUS: 85124610528
Cunha-Silva S., Osswald M., Goemann J., Barbosa J., Santos L.M., Resende P., Bange T., Ferrás C., Sunkel C.E., Conde C.
Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology219(3):, 2020. [Journal: Article] [CI: 11] [IF: 10,5]
DOI: 10.1083/jcb.201906039 SCOPUS: 85077707501
Barbosa J., Martins T., Bange T., Tao L., Conde C., Sunkel C.
Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments. EMBO Journal39(2):, 2020. [Journal: Article] [CI: 15] [IF: 11,6]
DOI: 10.15252/embj.2018100789 SCOPUS: 85076772192
Conde C., Gassmann R.
Spindle checkpoint: trapped by the corona, cyclin B1 goes MAD. EMBO Journal39(12):, 2020. [Journal: Note] [CI: 4] [IF: 11,6]
DOI: 10.15252/embj.2020105279 SCOPUS: 85086043496
Cunha-Silva S., Conde C.
From the Nuclear Pore to the Fibrous Corona: A MAD Journey to Preserve Genome Stability. BioEssays42(11):, 2020. [Journal: Article] [IF: 4.3]
DOI: 10.1002/bies.202000132 SCOPUS: 85090236878
Barbosa J., Conde C., Sunkel C.
RZZ-SPINDLY-DYNEIN: you got to keep ‘em separated. Cell Cycle19(14):1716-1726, 2020. [Journal: Article] [CI: 5] [IF: 4,5]
DOI: 10.1080/15384101.2020.1780382 SCOPUS: 85086926601
Moura M., Conde C.
Phosphatases in Mitosis: Roles and regulation. Biomolecules9(2):, 2019. [Journal: Review] [CI: 57] [IF: 4,1]
DOI: 10.3390/biom9020055 SCOPUS: 85061231058
Oliveira M.S., Freitas J., Pinto P.A.B., De Jesus A., Tavares J., Pinho M., Domingues R.G., Henriques T., Lopes C., Conde C., Sunkel C.E., Moreira A.
Cell cycle kinase polo is controlled by a widespread 3=untranslated region regulatory sequence in Drosophila melanogaster. Molecular and Cellular Biology39(15):, 2019. [Journal: Article] [CI: 5] [IF: 3,6]
DOI: 10.1128/MCB.00581-18 SCOPUS: 85070024885
Nellikka R.K., Sreeja J.S., Dharmapal D., John R., Monteiro A., Macedo J.C., Conde C., Logarinho E., Sunkel C.E., Sengupta S.
α-Fodrin is required for the organization of functional microtubules during mitosis. Cell Cycle18(20):2713-2726, 2019. [Journal: Article] [CI: 4] [IF: 3,7]
DOI: 10.1080/15384101.2019.1656476 SCOPUS: 85071323681
Moura M., Osswald M., Leça N., Barbosa J., Pereira A.J., Maiato H., Sunkel C.E., Conde C.
Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing. eLife6:, 2017. [Journal: Article] [CI: 42] [IF: 7,6]
DOI: 10.7554/eLife.25366 SCOPUS: 85019849461
Conde C., Osswald M., Barbosa J., Moutinho-Santos T., Pinheiro D., Guimarães S., Matos I., Maiato H., Sunkel C.E.
Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation. EMBO Journal32(12):1761-1777, 2013. [Journal: Article] [CI: 38] [IF: 10,7]
DOI: 10.1038/emboj.2013.109 SCOPUS: 84879459640
Conde C., Osswald M., Sunkel C.
All together now: Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila. Fly7(4):224-228, 2013. [Journal: Article] [CI: 2] [IF: 1,5]
DOI: 10.4161/fly.26231 SCOPUS: 84929510642
Moutinho-Santos T., Conde C., Sunkel C.
POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments. Journal of Cell Science125(3):576-583, 2012. [Journal: Article] [CI: 19] [IF: 5,9]
DOI: 10.1242/jcs.092445 SCOPUS: 84858139777
SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN. Journal of Cell Biology221(11):, 2022. [Journal: Article] [CI: 1] [IF: 7,8]
DOI: 10.1083/jcb.202209063 SCOPUS: 85139360830
Barbosa J., Sunkel C.E., Conde C.
The Role of Mitotic Kinases and the RZZ Complex in Kinetochore-Microtubule Attachments: Doing the Right Link. Frontiers in Cell and Developmental Biology10:, 2022. [Journal: Review] [CI: 7] [IF: 5,5]
DOI: 10.3389/fcell.2022.787294 SCOPUS: 85124610528
Cunha-Silva S., Osswald M., Goemann J., Barbosa J., Santos L.M., Resende P., Bange T., Ferrás C., Sunkel C.E., Conde C.
Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology219(3):, 2020. [Journal: Article] [CI: 11] [IF: 10,5]
DOI: 10.1083/jcb.201906039 SCOPUS: 85077707501
Barbosa J., Martins T., Bange T., Tao L., Conde C., Sunkel C.
Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments. EMBO Journal39(2):, 2020. [Journal: Article] [CI: 15] [IF: 11,6]
DOI: 10.15252/embj.2018100789 SCOPUS: 85076772192
Conde C., Gassmann R.
Spindle checkpoint: trapped by the corona, cyclin B1 goes MAD. EMBO Journal39(12):, 2020. [Journal: Note] [CI: 4] [IF: 11,6]
DOI: 10.15252/embj.2020105279 SCOPUS: 85086043496
Cunha-Silva S., Conde C.
From the Nuclear Pore to the Fibrous Corona: A MAD Journey to Preserve Genome Stability. BioEssays42(11):, 2020. [Journal: Article] [IF: 4.3]
DOI: 10.1002/bies.202000132 SCOPUS: 85090236878
Barbosa J., Conde C., Sunkel C.
RZZ-SPINDLY-DYNEIN: you got to keep ‘em separated. Cell Cycle19(14):1716-1726, 2020. [Journal: Article] [CI: 5] [IF: 4,5]
DOI: 10.1080/15384101.2020.1780382 SCOPUS: 85086926601
Moura M., Conde C.
Phosphatases in Mitosis: Roles and regulation. Biomolecules9(2):, 2019. [Journal: Review] [CI: 57] [IF: 4,1]
DOI: 10.3390/biom9020055 SCOPUS: 85061231058
Oliveira M.S., Freitas J., Pinto P.A.B., De Jesus A., Tavares J., Pinho M., Domingues R.G., Henriques T., Lopes C., Conde C., Sunkel C.E., Moreira A.
Cell cycle kinase polo is controlled by a widespread 3=untranslated region regulatory sequence in Drosophila melanogaster. Molecular and Cellular Biology39(15):, 2019. [Journal: Article] [CI: 5] [IF: 3,6]
DOI: 10.1128/MCB.00581-18 SCOPUS: 85070024885
Nellikka R.K., Sreeja J.S., Dharmapal D., John R., Monteiro A., Macedo J.C., Conde C., Logarinho E., Sunkel C.E., Sengupta S.
α-Fodrin is required for the organization of functional microtubules during mitosis. Cell Cycle18(20):2713-2726, 2019. [Journal: Article] [CI: 4] [IF: 3,7]
DOI: 10.1080/15384101.2019.1656476 SCOPUS: 85071323681
Moura M., Osswald M., Leça N., Barbosa J., Pereira A.J., Maiato H., Sunkel C.E., Conde C.
Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing. eLife6:, 2017. [Journal: Article] [CI: 42] [IF: 7,6]
DOI: 10.7554/eLife.25366 SCOPUS: 85019849461
Conde C., Osswald M., Barbosa J., Moutinho-Santos T., Pinheiro D., Guimarães S., Matos I., Maiato H., Sunkel C.E.
Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation. EMBO Journal32(12):1761-1777, 2013. [Journal: Article] [CI: 38] [IF: 10,7]
DOI: 10.1038/emboj.2013.109 SCOPUS: 84879459640
Conde C., Osswald M., Sunkel C.
All together now: Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila. Fly7(4):224-228, 2013. [Journal: Article] [CI: 2] [IF: 1,5]
DOI: 10.4161/fly.26231 SCOPUS: 84929510642
Moutinho-Santos T., Conde C., Sunkel C.
POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments. Journal of Cell Science125(3):576-583, 2012. [Journal: Article] [CI: 19] [IF: 5,9]
DOI: 10.1242/jcs.092445 SCOPUS: 84858139777