Carlos Conde

Cell Division & Genomic Stability

Associate Researcher

Carlos Conde (CC) is an Associate Researcher at i3S – Instituto de Investigação e Inovação em Saúde since 2015. He addresses fundamental questions on genome partitioning in order to understand why it fails so frequently in cancer. CC is focused on understanding the mechanisms underlying centromere structure, kinetochore-microtubule interactions and spindle assembly checkpoint signalling (SAC) and how defects in these processes impact on chromosomal instability (CIN) and tumorigenesis. To tackle these questions, CC combines in vitro biochemical and structural studies with functional analysis in human cells and Drosophila tissues.

Selected Publications

Barbosa J., Sunkel C.E., Conde C.,

SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN. Journal of Cell Biology221(11):, 2022. [Journal: Article] [IF: 7,8]
DOI: 10.1083/jcb.202209063 SCOPUS: 85139360830.

Barbosa J., Sunkel C.E., Conde C.,

The Role of Mitotic Kinases and the RZZ Complex in Kinetochore-Microtubule Attachments: Doing the Right Link. Frontiers in Cell and Developmental Biology10:, 2022. [Journal: Review] [CI: 3] [IF: 5,5]
DOI: 10.3389/fcell.2022.787294 SCOPUS: 85124610528.

Cunha-Silva S., Osswald M., Goemann J., Barbosa J., Santos L.M., Resende P., Bange T., Ferrás C., Sunkel C.E., Conde C.,

Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology219(3):, 2020. [Journal: Article] [CI: 9] [IF: 10,5]
DOI: 10.1083/jcb.201906039 SCOPUS: 85077707501.

Barbosa J., Martins T., Bange T., Tao L., Conde C., Sunkel C.,

Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments. EMBO Journal39(2):, 2020. [Journal: Article] [CI: 13] [IF: 11,6]
DOI: 10.15252/embj.2018100789 SCOPUS: 85076772192.

Conde C., Gassmann R.,

Spindle checkpoint: trapped by the corona, cyclin B1 goes MAD. EMBO Journal39(12):, 2020. [Journal: Note] [CI: 4] [IF: 11,6]
DOI: 10.15252/embj.2020105279 SCOPUS: 85086043496.

Cunha-Silva S., Conde C.,

From the Nuclear Pore to the Fibrous Corona: A MAD Journey to Preserve Genome Stability. BioEssays42(11):, 2020. [Journal: Article] [IF: 4.3]
DOI: 10.1002/bies.202000132 SCOPUS: 85090236878.

Barbosa J., Conde C., Sunkel C.,

RZZ-SPINDLY-DYNEIN: you got to keep ‘em separated. Cell Cycle19(14):1716-1726, 2020. [Journal: Article] [CI: 4] [IF: 4,5]
DOI: 10.1080/15384101.2020.1780382 SCOPUS: 85086926601.

Moura M., Conde C.,

Phosphatases in Mitosis: Roles and regulation. Biomolecules9(2):, 2019. [Journal: Review] [CI: 49] [IF: 4,1]
DOI: 10.3390/biom9020055 SCOPUS: 85061231058.

Oliveira M.S., Freitas J., Pinto P.A.B., De Jesus A., Tavares J., Pinho M., Domingues R.G., Henriques T., Lopes C., Conde C., Sunkel C.E., Moreira A.,

Cell cycle kinase polo is controlled by a widespread 3=untranslated region regulatory sequence in Drosophila melanogaster. Molecular and Cellular Biology39(15):, 2019. [Journal: Article] [CI: 4] [IF: 3,6]
DOI: 10.1128/MCB.00581-18 SCOPUS: 85070024885.

Nellikka R.K., Sreeja J.S., Dharmapal D., John R., Monteiro A., Macedo J.C., Conde C., Logarinho E., Sunkel C.E., Sengupta S.,

a-Fodrin is required for the organization of functional microtubules during mitosis. Cell Cycle18(20):2713-2726, 2019. [Journal: Article] [CI: 4] [IF: 3,7]
DOI: 10.1080/15384101.2019.1656476 SCOPUS: 85071323681.

Moura M., Osswald M., Leça N., Barbosa J., Pereira A.J., Maiato H., Sunkel C.E., Conde C.,

Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing. eLife6:, 2017. [Journal: Article] [CI: 39] [IF: 7,6]
DOI: 10.7554/eLife.25366 SCOPUS: 85019849461.

Conde C., Osswald M., Barbosa J., Moutinho-Santos T., Pinheiro D., Guimarães S., Matos I., Maiato H., Sunkel C.E.,

Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation. EMBO Journal32(12):1761-1777, 2013. [Journal: Article] [CI: 37] [IF: 10,7]
DOI: 10.1038/emboj.2013.109 SCOPUS: 84879459640.

Conde C., Osswald M., Sunkel C.E.,

All together now: Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila. Fly7(4):224-228, 2013. [Journal: Article] [CI: 2] [IF: 1,5]
DOI: 10.4161/fly.26231 SCOPUS: 84929510642.

Moutinho-Santos T., Conde C., Sunkel C.E.,

POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments. Journal of Cell Science125(3):576-583, 2012. [Journal: Article] [CI: 18] [IF: 5,9]
DOI: 10.1242/jcs.092445 SCOPUS: 84858139777.