José das Neves

Nanomedicines & Translational Drug Delivery

Project Leader

José das Neves is Assistant Researcher at i3S/INEB since 2019. He graduated in Pharmaceutical Sciences (2003) and holds a MSc in Pharmaceutical Technology (2007) and a PhD in Pharmaceutical Sciences (2013) from the University of Porto, Portugal. Prior to engaging in a full-time research career, he gained experience in drug therapeutics as a Pharmacist at the Hospital Geral de Sto. António, Portugal (2004-2009). José was a visiting PhD student at Northeastern University (USA) in 2009-2010 and at the Institute of Tropical Medicine (Belgium) in 2010. After completing his PhD, he moved to INEB as a Postdoc/Junior Researcher (2014-2019). His broad research interest includes nanomedicine, mucosal drug delivery and biomaterials. José's current research focuses specifically on the development of drug delivery strategies for the prevention or treatment of sexually transmitted infections and lower female genital tract diseases. As of June 2020, he is the author of 68 peer-reviewed articles, 11 book chapters, 74 presentations at scientific meetings and 1 international patent. He is the co-Editor of 4 scientific books, Associate Editor of Frontiers in Pharmacology (Frontiers Media), and Editorial Board member of PLOS ONE (Public Library of Science), Pharmaceutics (MDPI), Nanomaterials (MDPI), Drug Delivery Letters (Bentham Science) and 4Open (EDP Sciences). He is also an active collaborator of the Global Burden of Disease Study, contributing to 30 peer-reviewed articles from this international consortium.

Selected Publications

das Neves J., Nunes R., Rodrigues F., Sarmento B.,

Nanomedicine in the development of anti-HIV microbicides. Advanced Drug Delivery Reviews103:57-75, 2016. [Journal: Review] [CI: 35] [IF: 11,8]
DOI: 10.1016/j.addr.2016.01.017 SCOPUS: 84957927659.

Cunha-Reis C., Machado A., Barreiros L., Araújo F., Nunes R., Seabra V., Ferreira D., Segundo M.A., Sarmento B., das Neves J.,

Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs. Journal of Controlled Release243:43-53, 2016. [Journal: Article] [CI: 45] [IF: 7,8]
DOI: 10.1016/j.jconrel.2016.09.020 SCOPUS: 84990849820.

Machado A., Cunha-Reis C., Araújo F., Nunes R., Seabra V., Ferreira D., das Neves J., Sarmento B.,

Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system. Acta Biomaterialia44:332-340, 2016. [Journal: Article] [CI: 37] [IF: 6,3]
DOI: 10.1016/j.actbio.2016.08.018 SCOPUS: 84992121833.

Cautela M.P., Moshe H., Sosnik A., Sarmento B., das Neves J.,

Composite films for vaginal delivery of tenofovir disoproxil fumarate and emtricitabine. European Journal of Pharmaceutics and Biopharmaceutics138:3-10, 2019. [Journal: Article] [CI: 10] [IF: 4,6]
DOI: 10.1016/j.ejpb.2018.02.001 SCOPUS: 85044614712.

Nunes R., Araújo F., Tavares J., Sarmento B., das Neves J.,

Surface modification with polyethylene glycol enhances colorectal distribution and retention of nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics130:200-206, 2018. [Journal: Article] [CI: 12] [IF: 4,7]
DOI: 10.1016/j.ejpb.2018.06.029 SCOPUS: 85049465651.

Lechanteur A., das Neves J., Sarmento B.,

The role of mucus in cell-based models used to screen mucosal drug delivery. Advanced Drug Delivery Reviews124:50-63, 2018. [Journal: Review] [CI: 36] [IF: 15,5]
DOI: 10.1016/j.addr.2017.07.019 SCOPUS: 85026524492.

das Neves J., Sarmento B.,

Antiretroviral drug-loaded nanoparticles-in-films: a new option for developing vaginal microbicides?. Expert Opinion on Drug Delivery14(4):449-452, 2017. [Journal: Editorial] [CI: 10] [IF: 5,6]
DOI: 10.1080/17425247.2017.1270938 SCOPUS: 85006172803.

Nunes R., Araújo F., Barreiros L., Bártolo I., Segundo M.A., Taveira N., Sarmento B., Das Neves J.,

Noncovalent PEG Coating of Nanoparticle Drug Carriers Improves the Local Pharmacokinetics of Rectal Anti-HIV Microbicides. ACS Applied Materials and Interfaces10(41):34942-34953, 2018. [Journal: Article] [CI: 16] [IF: 8,5]
DOI: 10.1021/acsami.8b12214 SCOPUS: 85054761997.

Mesquita L., Galante J., Nunes R., Sarmento B., Neves J.D.,

Pharmaceutical vehicles for vaginal and rectal administration of anti-hivmicrobicide nanosystems. Pharmaceutics11(3):, 2019. [Journal: Review] [CI: 11] [IF: 4,4]
DOI: 10.3390/pharmaceutics11030145 SCOPUS: 85064733632.

Melo M., Nunes R., Sarmento B., Das Neves J.,

Colorectal distribution and retention of polymeric nanoparticles following incorporation into a thermosensitive enema. Biomaterials Science7(9):3801-3811, 2019. [Journal: Article] [CI: 2] [IF: 6,2]
DOI: 10.1039/c9bm00759h SCOPUS: 85071385635.

Leong H.S., Butler K.S., Brinker C.J., Azzawi M., Conlan S., Dufés C., Owen A., Rannard S., Scott C., Chen C., Dobrovolskaia M.A., Kozlov S.V., Prina-Mello A., Schmid R., Wick P., Caputo F., Boisseau P., Crist R.M., McNeil S.E., Fadeel B., Tran L., Hansen S.F., Hartmann N.B., Clausen L.P.W., Skjolding L.M., Baun A., Ågerstrand M., Gu Z., Lamprou D.A., Hoskins C., Huang L., Song W., Cao H., Liu X., Jandt K.D., Jiang W., Kim B.Y.S., Wheeler K.E., Chetwynd A.J., Lynch I., Moghimi S.M., Nel A., Xia T., Weiss P.S., Sarmento B., das Neves J., Santos H.A., Santos L., Mitragotri S., Little S., Peer D., Amiji M.M., Alonso M.J., Petri-Fink A., Balog S., Lee A., Drasler B., Rothen-Rutishauser B., Wilhelm S., Acar H., Harrison R.G., Mao C., Mukherjee P., Ramesh R., McNally L.R., Busatto S., Wolfram J., Bergese P., Ferrari M., Fang R.H., Zhang L., Zheng J., Peng C., Du B., Yu M., Charron D.M., Zheng G., Pastore C.,

On the issue of transparency and reproducibility in nanomedicine. Nature Nanotechnology14(7):629-635, 2019. [Journal: Letter] [CI: 56] [IF: 31,5]
DOI: 10.1038/s41565-019-0496-9 SCOPUS: 85069268486.

Faria M.J., Machado R., Ribeiro A., Gonçalves H., Real Oliveira M.E.C.D., Viseu T., Neves J.D., Lúcio M.,

Rational development of liposomal hydrogels: A strategy for topical vaginal antiretroviral drug delivery in the context of HIV prevention. Pharmaceutics11(9):, 2019. [Journal: Article] [CI: 9] [IF: 4,4]
DOI: 10.3390/pharmaceutics11090485 SCOPUS: 85073295474.

Santovito E., das Neves J., Greco D., D’Ascanio V., Sarmento B., Logrieco A.F., Avantaggiato G.,

Antimicrobial properties of rosin acids-loaded nanoparticles against antibiotic-sensitive and antibiotic-resistant foodborne pathogens. Artificial Cells, Nanomedicine and Biotechnology46(sup3):S414-S422, 2018. [Journal: Article] [CI: 4] [IF: 4,5]
DOI: 10.1080/21691401.2018.1496924 SCOPUS: 85058163908.

Fernandes T., Baxi K., Sawarkar S., Sarmento B., das Neves J.,

Vaginal multipurpose prevention technologies: promising approaches for enhancing women’s sexual and reproductive health. Expert Opinion on Drug Delivery17(3):379-393, 2020. [Journal: Review] [IF: 4,8 (*)]
DOI: 10.1080/17425247.2020.1728251 SCOPUS: 85079724834.