Where Ideas grow
Tiago Duarte
Junior Researcher
TL Duarte graduated in Biology by the University of Lisbon in 2000. In 2007, TL Duarte obtained his PhD from the University of Leicester (UK), for investigating the so-called non-antioxidant roles of vitamin C. Since becoming an independently funded researcher at IBMC in 2009, his research interests focused on the search for modifiers of iron overload-related liver disease. TL Duarte demonstrated the crucial hepatoprotectant role of transcription factor NRF2 against iron toxicity in mice, and more recently the ability of NRF2 to sense toxic iron and regulate BMP6/hepcidin signalling.

Selected Publications

Lim P.J., Duarte T.L., Arezes J., Garcia-Santos D., Hamdi A., Pasricha S.R., Armitage A.E., Mehta H., Wideman S., Santos A.G., Santos-Gonçalves A., Morovat A., Hughes J.R., Soilleux E., Wang C.Y., Bayer A.L., Klenerman P., Willberg C.B., Hartley R.C., Murphy M.P., Babitt J.L., Ponka P., Porto G., Drakesmith H.,
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature Metabolism1(5):519-531, 2019. [Journal: Article] [CI: 8]
DOI: 10.1038/s42255-019-0063-6 SCOPUS: 85071448817.

Pasricha S.R., Lim P.J., Duarte T.L., Casu C., Oosterhuis D., Mleczko-Sanecka K., Suciu M., Da Silva A.R., Al-Hourani K., Arezes J., McHugh K., Gooding S., Frost J.N., Wray K., Santos A., Porto G., Repapi E., Gray N., Draper S.J., Ashley N., Soilleux E., Olinga P., Muckenthaler M.U., Hughes J.R., Rivella S., Milne T.A., Armitage A.E., Drakesmith H.,
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature Communications8(1):, 2017. [Journal: Article] [CI: 19] [IF: 12,4]
DOI: 10.1038/s41467-017-00500-z SCOPUS: 85028636590.

Duarte T.L., Caldas C., Santos A.G., Silva-Gomes S., Santos-Gonçalves A., Martins M.J., Porto G., Lopes J.M.,
Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis. Redox Biology11:157-169, 2017. [Journal: Article] [CI: 15] [IF: 7,1]
DOI: 10.1016/j.redox.2016.11.013 SCOPUS: 85002982394.

Chambel S.S., Santos-Gonçalves A., Duarte T.L.,
The dual role of Nrf2 in nonalcoholic fatty liver disease: Regulation of antioxidant defenses and hepatic lipid metabolism. BioMed Research International2015:, 2015. [Journal: Article] [CI: 44] [IF: 2,1]
DOI: 10.1155/2015/597134 SCOPUS: 84930625964.

Silva-Gomes S., Santos A.G., Caldas C., Silva C.M., Neves J.V., Lopes J., Carneiro F., Rodrigues P.N., Duarte T.L.,
Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death. Journal of Hepatology60(2):354-361, 2014. [Journal: Article] [CI: 28] [IF: 11,3]
DOI: 10.1016/j.jhep.2013.09.004 SCOPUS: 84892559263.

Duarte T.L., Cooke M.S., Jones G.D.D.,
Gene expression profiling reveals new protective roles for vitamin C in human skin cells. Free Radical Biology and Medicine46(1):78-87, 2009. [Journal: Article] [CI: 68] [IF: 6,1]
DOI: 10.1016/j.freeradbiomed.2008.09.028 SCOPUS: 57449102928.

Corti A., Duarte T.L., Giommarelli C., De Tata V., Paolicchi A., Jones G.D.D., Pompella A.,
Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis669(1-2):112-121, 2009. [Journal: Article] [CI: 37] [IF: 3,6]
DOI: 10.1016/j.mrfmmm.2009.05.010 SCOPUS: 70349152500.

Duarte T.L., Jones G.D.D.,
Vitamin C modulation of H2O2-induced damage and iron homeostasis in human cells. Free Radical Biology and Medicine43(8):1165-1175, 2007. [Journal: Article] [CI: 46] [IF: 4,8]
DOI: 10.1016/j.freeradbiomed.2007.07.017 SCOPUS: 34548489878.

Duarte T.L., Almeida G.M., Jones G.D.D.,
Investigation of the role of extracellular H2O2 and transition metal ions in the genotoxic action of ascorbic acid in cell culture models. Toxicology Letters170(1):57-65, 2007. [Journal: Article] [CI: 51] [IF: 2,8]
DOI: 10.1016/j.toxlet.2007.02.005 SCOPUS: 33947628181.

Duarte T.L., Lunec J.,
Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radical Research39(7):671-686, 2005. [Journal: Review] [CI: 209] [IF: 2,3]
DOI: 10.1080/10715760500104025 SCOPUS: 21844465931.