Where Ideas Grow
Tiago Duarte
Junior Researcher
TL Duarte graduated in Biology by the University of Lisbon in 2000. In 2007, TL Duarte obtained his PhD from the University of Leicester (UK), for investigating the so-called ?non-antioxidant? roles of vitamin C. Since becoming an independently funded researcher at IBMC in 2009, his research interests focused on the search for modifiers of iron overload-related liver disease. TL Duarte demonstrated the crucial hepatoprotectant role of transcription factor NRF2 against iron toxicity in mice, and more recently the ability of NRF2 to sense toxic iron and regulate BMP6/hepcidin signalling.

Selected Publications

Lopes M., Duarte T.L., Teles M.J., Mosteo L., Chacim S., Aguiar E., Pereira-Reis J., Oliveira M., Silva A.M.N., Goncalves N., Martins G., Kong I.Y., Zethoven M., Vervoort S., Martins S., Quintela M., Hawkins E.D., Trigo F., Guimaraes J.T., Mariz J.M., Porto G., Duarte D.,
Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications. Blood Advances5(16):3102-3112, 2021. [Journal: Article] [CI: 1] [IF: 7,6]
DOI: 10.1182/bloodadvances.2021004373 SCOPUS: 85113994709.

Duarte T.L., Talbot N.P., Drakesmith H.,
NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis. Antioxidants and Redox Signaling35(6):433-452, 2021. [Journal: Review] [CI: 9] [IF: 7,5]
DOI: 10.1089/ars.2020.8148 SCOPUS: 85111760761.

Frost J.N., Tan T.K., Abbas M., Wideman S.K., Bonadonna M., Stoffel N.U., Wray K., Kronsteiner B., Smits G., Campagna D.R., Duarte T.L., Lopes J.M., Shah A., Armitage A.E., Arezes J., Lim P.J., Preston A.E., Ahern D., Teh M., Naylor C., Salio M., Gileadi U., Andrews S.C., Dunachie S.J., Zimmermann M.B., van der Klis F.R.M., Cerundolo V., Bannard O., Draper S.J., Townsend A.R.M., Galy B., Fleming M.D., Lewis M.C., Drakesmith H.,
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection. Med2(2):164-179.e12, 2021. [Journal: Article] [CI: 21]
DOI: 10.1016/j.medj.2020.10.004 SCOPUS: 85103960664.

Lim P.J., Duarte T.L., Arezes J., Garcia-Santos D., Hamdi A., Pasricha S.R., Armitage A.E., Mehta H., Wideman S., Santos A.G., Santos-Gonçalves A., Morovat A., Hughes J.R., Soilleux E., Wang C.Y., Bayer A.L., Klenerman P., Willberg C.B., Hartley R.C., Murphy M.P., Babitt J.L., Ponka P., Porto G., Drakesmith H.,
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature Metabolism1(5):519-531, 2019. [Journal: Article] [CI: 52]
DOI: 10.1038/s42255-019-0063-6 SCOPUS: 85071448817.

Pasricha S.R., Lim P.J., Duarte T.L., Casu C., Oosterhuis D., Mleczko-Sanecka K., Suciu M., Da Silva A.R., Al-Hourani K., Arezes J., McHugh K., Gooding S., Frost J.N., Wray K., Santos A., Porto G., Repapi E., Gray N., Draper S.J., Ashley N., Soilleux E., Olinga P., Muckenthaler M.U., Hughes J.R., Rivella S., Milne T.A., Armitage A.E., Drakesmith H.,
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature Communications8(1):, 2017. [Journal: Article] [CI: 26] [IF: 12,4]
DOI: 10.1038/s41467-017-00500-z SCOPUS: 85028636590.

Duarte T.L., Caldas C., Santos A.G., Silva-Gomes S., Santos-Gonçalves A., Martins M.J., Porto G., Lopes J.M.,
Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis. Redox Biology11:157-169, 2017. [Journal: Article] [CI: 27] [IF: 7,1]
DOI: 10.1016/j.redox.2016.11.013 SCOPUS: 85002982394.

Chambel S.S., Santos-Gonçalves A., Duarte T.L.,
The dual role of Nrf2 in nonalcoholic fatty liver disease: Regulation of antioxidant defenses and hepatic lipid metabolism. BioMed Research International2015:, 2015. [Journal: Article] [CI: 89] [IF: 2,1]
DOI: 10.1155/2015/597134 SCOPUS: 84930625964.

Silva-Gomes S., Santos A.G., Caldas C., Silva C.M., Neves J.V., Lopes J., Carneiro F., Rodrigues P.N., Duarte T.L.,
Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death. Journal of Hepatology60(2):354-361, 2014. [Journal: Article] [CI: 40] [IF: 11,3]
DOI: 10.1016/j.jhep.2013.09.004 SCOPUS: 84892559263.

Duarte T.L., Cooke M.S., Jones G.D.D.,
Gene expression profiling reveals new protective roles for vitamin C in human skin cells. Free Radical Biology and Medicine46(1):78-87, 2009. [Journal: Article] [CI: 81] [IF: 6,1]
DOI: 10.1016/j.freeradbiomed.2008.09.028 SCOPUS: 57449102928.

Duarte T.L., Jones G.D.D.,
Vitamin C modulation of H2O2-induced damage and iron homeostasis in human cells. Free Radical Biology and Medicine43(8):1165-1175, 2007. [Journal: Article] [CI: 48] [IF: 4,8]
DOI: 10.1016/j.freeradbiomed.2007.07.017 SCOPUS: 34548489878.