Where Ideas grow
Didier Cabanes
Group leader
Didier Cabanes obtained a PhD in Molecular Biology from the Université Toulouse III - Paul Sabatier in 2000, on the identification and characterization of Sinorhizobium meliloti genes regulated during symbiosis with Medicago sativa under the supervision of J. Batut, INRA, Toulouse. He then made a Post-Doc in the laboratory of Pascale Cossart at Institut Pasteur Paris, studying the mechanisms of virulence of Listeria monocytogenes. In 2005 he joined the IBMC (Porto, Portugal) to create the Group of Molecular Microbiology (GM2). He is currently Coordinator of the Unit of Infection and Immunity of the IBMC and Coordinator of the Host Response and Interaction Research Program of the i3S. He is Member of the Scientific Board of the MCbiology PhD Program and Coordinator of a module of the GABBA PhD Program. He is Editor for Research in Microbiology. His current research aims are to decipher the virulence arsenal of Listeria monocytogenes and characterize the role of different components of the host cytoskeleton in the cellular infection process of bacterial pathogens.

Selected Publications

Pinheiro J., Lisboa J., Pombinho R., Carvalho F., Carreaux A., Brito C., Pöntinen A., Korkeala H., Dos Santos N.M.S., Morais-Cabral J.H., Sousa S., Cabanes D.,
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Research46(18):9338-9352, 2018. [Journal: Article] [CI: 10] [IF: 11,1]
DOI: 10.1093/nar/gky624 SCOPUS: 85054896319.

Carvalho F., Sousa S., Cabanes D.,
l-Rhamnosylation of wall teichoic acids promotes efficient surface association of Listeria monocytogenes virulence factors InlB and Ami through interaction with GW domains. Environmental Microbiology20(11):3941-3951, 2018. [Journal: Article] [CI: 8] [IF: 5,1]
DOI: 10.1111/1462-2920.14351 SCOPUS: 85056596957.

Pombinho R., Sousa S., Cabanes D.,
Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis. Critical Reviews in Microbiology44(6):685-700, 2018. [Journal: Review] [CI: 5] [IF: 5,7]
DOI: 10.1080/1040841X.2018.1493716 SCOPUS: 85060399826.

Pombinho R., Camejo A., Vieira A., Reis O., Carvalho F., Almeida M.T., Pinheiro J.C., Sousa S., Cabanes D.,
Listeria monocytogenes CadC regulates cadmium efflux and fine-tunes lipoprotein localization to escape the host immune response and promote infection. Journal of Infectious Diseases215(9):1468-1479, 2017. [Journal: Article] [CI: 9] [IF: 5,2]
DOI: 10.1093/infdis/jix118 SCOPUS: 85021919420.

Pinheiro J., Reis O., Vieira A., Moura I.M., Moreno L.Z., Carvalho F., Pucciarelli M.G., García-del Portillo F., Sousa S., Cabanes D.,
Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection. Virulence8(6):993-1004, 2017. [Journal: Article] [CI: 8] [IF: 3,9]
DOI: 10.1080/21505594.2016.1244589 SCOPUS: 84992702646.

Mesquita F.S., Brito C., Mazon Moya M.J., Pinheiro J.C., Mostowy S., Cabanes D., Sousa S.,
Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO Reports18(2):303-318, 2017. [Journal: Article] [CI: 9] [IF: 8,7]
DOI: 10.15252/embr.201642833 SCOPUS: 85007487818.

Carvalho F., Atilano M.L., Pombinho R., Covas G., Gallo R.L., Filipe S.R., Sousa S., Cabanes D.,
L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane. PLoS Pathogens11(5):, 2015. [Journal: Article] [CI: 38] [IF: 7]
DOI: 10.1371/journal.ppat.1004919 SCOPUS: 84930354332.

Carvalho F., Sousa S., Cabanes D.,
How Listeria monocytogenes organizes its surface for virulence. Frontiers in Cellular and Infection Microbiology4(APR):, 2014. [Journal: Review] [CI: 33] [IF: 3,7]
DOI: 10.3389/fcimb.2014.00048 SCOPUS: 84924841119.

Lebreton A., Lakisic G., Job V., Fritsch L., Tham T.N., Camejo A., Matteï P.J., Regnault B., Nahori M.A., Cabanes D., Gautreau A., Ait-Si-Ali S., Dessen A., Cossart P., Bierne H.,
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science331(6022):1319-1321, 2011. [Journal: Article] [CI: 114] [IF: 31,2]
DOI: 10.1126/science.1200120 SCOPUS: 79952515250.

Camejo A., Buchrieser C., Couvé E., Carvalho F., Reis O., Ferreira P., Sousa S., Cossart P., Cabanes D.,
In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection. PLoS Pathogens5(5):, 2009. [Journal: Article] [CI: 145] [IF: 9]
DOI: 10.1371/journal.ppat.1000449 SCOPUS: 67249147690.