creating a
healthier future
Didier Cabanes
Group leader

Didier Cabanes obtained a PhD in Molecular Biology from the Université Toulouse III - Paul Sabatier in 2000, on the identification and characterization of Sinorhizobium meliloti genes regulated during symbiosis with Medicago sativa under the supervision of J. Batut, INRA, Toulouse. D. Cabanes then made a Post-Doc in the laboratory of Pascale Cossart at Institut Pasteur Paris, studying the mechanisms of virulence of Listeria monocytogenes. In 2005, he joined the IBMC (Porto, Portugal) to create the Group of Molecular Microbiology (GM2). He is currently i3S Vice-Director and Coordinator of the i3S Research Program on Infection, Immunity and Regeneration. He is Member of the Scientific Board of the MCbiology PhD Program, and Editor for Research in Microbiology and Toxins. Using Listeria monocytogenes as model organism of intracellular parasitism, D. Cabanes current research aims to decipher how bacterial pathogens organize their surface and control gene expression to promote virulence, for the development of new antimicrobial approaches.

Selected Publications

Pinheiro J., Lisboa J., Pombinho R., Carvalho F., Carreaux A., Brito C., Pöntinen A., Korkeala H., Dos Santos N.M.S., Morais-Cabral J.H., Sousa S., Cabanes D.,
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Research46(18):9338-9352, 2018. [Journal: Article] [CI: 24] [IF: 11,1]
DOI: 10.1093/nar/gky624 SCOPUS: 85054896319.

Carvalho F., Sousa S., Cabanes D.,
l-Rhamnosylation of wall teichoic acids promotes efficient surface association of Listeria monocytogenes virulence factors InlB and Ami through interaction with GW domains. Environmental Microbiology20(11):3941-3951, 2018. [Journal: Article] [CI: 17] [IF: 5,1]
DOI: 10.1111/1462-2920.14351 SCOPUS: 85056596957.

Pombinho R., Sousa S., Cabanes D.,
Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis. Critical Reviews in Microbiology44(6):685-700, 2018. [Journal: Review] [CI: 19] [IF: 5,7]
DOI: 10.1080/1040841X.2018.1493716 SCOPUS: 85060399826.

Pombinho R., Camejo A., Vieira A., Reis O., Carvalho F., Almeida M.T., Pinheiro J.C., Sousa S., Cabanes D.,
Listeria monocytogenes CadC regulates cadmium efflux and fine-tunes lipoprotein localization to escape the host immune response and promote infection. Journal of Infectious Diseases215(9):1468-1479, 2017. [Journal: Article] [CI: 20] [IF: 5,2]
DOI: 10.1093/infdis/jix118 SCOPUS: 85021919420.

Pinheiro J., Reis O., Vieira A., Moura I.M., Moreno L.Z., Carvalho F., Pucciarelli M.G., García-del Portillo F., Sousa S., Cabanes D.,
Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection. Virulence8(6):993-1004, 2017. [Journal: Article] [CI: 17] [IF: 3,9]
DOI: 10.1080/21505594.2016.1244589 SCOPUS: 84992702646.

Mesquita F.S., Brito C., Mazon Moya M.J., Pinheiro J.C., Mostowy S., Cabanes D., Sousa S.,
Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO Reports18(2):303-318, 2017. [Journal: Article] [CI: 16] [IF: 8,7]
DOI: 10.15252/embr.201642833 SCOPUS: 85007487818.

Carvalho F., Atilano M.L., Pombinho R., Covas G., Gallo R.L., Filipe S.R., Sousa S., Cabanes D.,
L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane. PLoS Pathogens11(5):, 2015. [Journal: Article] [CI: 57] [IF: 7]
DOI: 10.1371/journal.ppat.1004919 SCOPUS: 84930354332.

Carvalho F., Sousa S., Cabanes D.,
How Listeria monocytogenes organizes its surface for virulence. Frontiers in Cellular and Infection Microbiology4(APR):, 2014. [Journal: Review] [CI: 53] [IF: 3,7]
DOI: 10.3389/fcimb.2014.00048 SCOPUS: 84924841119.

Lebreton A., Lakisic G., Job V., Fritsch L., Tham T.N., Camejo A., Matteï P.J., Regnault B., Nahori M.A., Cabanes D., Gautreau A., Ait-Si-Ali S., Dessen A., Cossart P., Bierne H.,
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science331(6022):1319-1321, 2011. [Journal: Article] [CI: 151] [IF: 31,2]
DOI: 10.1126/science.1200120 SCOPUS: 79952515250.

Camejo A., Buchrieser C., Couvé E., Carvalho F., Reis O., Ferreira P., Sousa S., Cossart P., Cabanes D.,
In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection. PLoS Pathogens5(5):, 2009. [Journal: Article] [CI: 168] [IF: 9]
DOI: 10.1371/journal.ppat.1000449 SCOPUS: 67249147690.