Didier Cabanes
Board of Directors
Coordinator of Infection, Immunity and Regeneration Program - i3S Board of Directors
Didier Cabanes obtained a PhD in Molecular Biology from the Université Toulouse III - Paul Sabatier in 2000, on the identification and characterization of Sinorhizobium meliloti genes regulated during symbiosis with Medicago sativa under the supervision of J. Batut, INRA, Toulouse. D. Cabanes then made a Post-Doc in the laboratory of Pascale Cossart at Institut Pasteur Paris, studying the mechanisms of virulence of Listeria monocytogenes. In 2005, he joined the IBMC (Porto, Portugal) to create the Group of Molecular Microbiology (GM2). He is currently i3S Vice-Director and Coordinator of the i3S Research Program on Infection, Immunity and Regeneration. He is Member of the Scientific Board of the MCbiology PhD Program, and Editor for Research in Microbiology and Toxins. Using Listeria monocytogenes as model organism of intracellular parasitism, D. Cabanes current research aims to decipher how bacterial pathogens organize their surface and control gene expression to promote virulence, for the development of new antimicrobial approaches.
Selected Publications
Alves Â., Meireles D., Suriano C., Monteiro R., Oliveira R., Bernardes B.G., Sousa S., Pombinho R., Cabanes D.
Automated high-throughput microscopy screening unveiled new Listeria monocytogenes genes involved in cell infection. Microbiological Research306:, 2026. [Journal: Article] [CI: 1] [IF: 8.5 (*)]
DOI: 10.1016/j.micres.2026.128442 SCOPUS: 105027632127
Monteiro R., Cereija T.B., Pombinho R., Voskuilen T., Codée J.D.C., Sousa S., Morais-Cabral J.H., Cabanes D.
Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes. Nature Communications16(1):, 2025. [Journal: Article] [CI: 9] [IF: 15.7 (*)]
DOI: 10.1038/s41467-024-55360-1 SCOPUS: 85213966038
Meireles D., Pombinho R., Cabanes D.
Signals behind Listeria monocytogenes virulence mechanisms. Gut Microbes16(1):, 2024. [Journal: Review] [CI: 39] [IF: 11]
DOI: 10.1080/19490976.2024.2369564 SCOPUS: 85198307808
Pombinho R., Pinheiro J., Resende M., Meireles D., Jalkanen S., Sousa S., Cabanes D.
Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment. Virulence12(1):2088-2103, 2021. [Journal: Article] [CI: 7] [IF: 5,4]
DOI: 10.1080/21505594.2021.1958606 SCOPUS: 85112346326
Meireles D., Pombinho R., Carvalho F., Sousa S., Cabanes D.
Listeria monocytogenes wall teichoic acid glycosylation promotes surface anchoring of virulence factors, resistance to antimicrobial peptides, and decreased susceptibility to antibiotics. Pathogens9(4):, 2020. [Journal: Article] [CI: 33] [IF: 3,5]
DOI: 10.3390/pathogens9040290 SCOPUS: 85084470635
Pombinho R., Vieira A., Camejo A., Archambaud C., Cossart P., Sousa S., Cabanes D.
Virulence gene repression promotes Listeria monocytogenes systemic infection. Gut Microbes11(4):868-881, 2020. [Journal: Article] [CI: 12] [IF: 10,2]
DOI: 10.1080/19490976.2020.1712983 SCOPUS: 85078271319
Pinheiro J., Lisboa J., Pombinho R., Carvalho F., Carreaux A., Brito C., Pöntinen A., Korkeala H., Dos Santos N.M.S., Morais-Cabral J.H., Sousa S., Cabanes D.
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Research46(18):9338-9352, 2018. [Journal: Article] [CI: 33] [IF: 11,1]
DOI: 10.1093/nar/gky624 SCOPUS: 85054896319
Carvalho F., Sousa S., Cabanes D.
l-Rhamnosylation of wall teichoic acids promotes efficient surface association of Listeria monocytogenes virulence factors InlB and Ami through interaction with GW domains. Environmental Microbiology20(11):3941-3951, 2018. [Journal: Article] [CI: 28] [IF: 5,1]
DOI: 10.1111/1462-2920.14351 SCOPUS: 85056596957
Pombinho R., Camejo A., Vieira A., Reis O., Carvalho F., Almeida M.T., Pinheiro J.C., Sousa S., Cabanes D.
Listeria monocytogenes CadC regulates cadmium efflux and fine-tunes lipoprotein localization to escape the host immune response and promote infection. Journal of Infectious Diseases215(9):1468-1479, 2017. [Journal: Article] [CI: 24] [IF: 5,2]
DOI: 10.1093/infdis/jix118 SCOPUS: 85021919420
Pinheiro J., Reis O., Vieira A., Moura I.M., Moreno L.Z., Carvalho F., Pucciarelli M.G., García-del Portillo F., Sousa S., Cabanes D.
Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection. Virulence8(6):993-1004, 2017. [Journal: Article] [CI: 21] [IF: 3,9]
DOI: 10.1080/21505594.2016.1244589 SCOPUS: 84992702646
Carvalho F., Atilano M.L., Pombinho R., Covas G., Gallo R.L., Filipe S.R., Sousa S., Cabanes D.
L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane. PLoS Pathogens11(5):, 2015. [Journal: Article] [CI: 79] [IF: 7]
DOI: 10.1371/journal.ppat.1004919 SCOPUS: 84930354332
Lebreton A., Lakisic G., Job V., Fritsch L., Tham T.N., Camejo A., Matteï P.J., Regnault B., Nahori M.A., Cabanes D., Gautreau A., Ait-Si-Ali S., Dessen A., Cossart P., Bierne H.
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science331(6022):1319-1321, 2011. [Journal: Article] [CI: 165] [IF: 31,2]
DOI: 10.1126/science.1200120 SCOPUS: 79952515250
Camejo A., Buchrieser C., Couvé E., Carvalho F., Reis O., Ferreira P., Sousa S., Cossart P., Cabanes D.
In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection. PLoS Pathogens5(5):, 2009. [Journal: Article] [CI: 191] [IF: 9]
DOI: 10.1371/journal.ppat.1000449 SCOPUS: 67249147690
Automated high-throughput microscopy screening unveiled new Listeria monocytogenes genes involved in cell infection. Microbiological Research306:, 2026. [Journal: Article] [CI: 1] [IF: 8.5 (*)]
DOI: 10.1016/j.micres.2026.128442 SCOPUS: 105027632127
Monteiro R., Cereija T.B., Pombinho R., Voskuilen T., Codée J.D.C., Sousa S., Morais-Cabral J.H., Cabanes D.
Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes. Nature Communications16(1):, 2025. [Journal: Article] [CI: 9] [IF: 15.7 (*)]
DOI: 10.1038/s41467-024-55360-1 SCOPUS: 85213966038
Meireles D., Pombinho R., Cabanes D.
Signals behind Listeria monocytogenes virulence mechanisms. Gut Microbes16(1):, 2024. [Journal: Review] [CI: 39] [IF: 11]
DOI: 10.1080/19490976.2024.2369564 SCOPUS: 85198307808
Pombinho R., Pinheiro J., Resende M., Meireles D., Jalkanen S., Sousa S., Cabanes D.
Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment. Virulence12(1):2088-2103, 2021. [Journal: Article] [CI: 7] [IF: 5,4]
DOI: 10.1080/21505594.2021.1958606 SCOPUS: 85112346326
Meireles D., Pombinho R., Carvalho F., Sousa S., Cabanes D.
Listeria monocytogenes wall teichoic acid glycosylation promotes surface anchoring of virulence factors, resistance to antimicrobial peptides, and decreased susceptibility to antibiotics. Pathogens9(4):, 2020. [Journal: Article] [CI: 33] [IF: 3,5]
DOI: 10.3390/pathogens9040290 SCOPUS: 85084470635
Pombinho R., Vieira A., Camejo A., Archambaud C., Cossart P., Sousa S., Cabanes D.
Virulence gene repression promotes Listeria monocytogenes systemic infection. Gut Microbes11(4):868-881, 2020. [Journal: Article] [CI: 12] [IF: 10,2]
DOI: 10.1080/19490976.2020.1712983 SCOPUS: 85078271319
Pinheiro J., Lisboa J., Pombinho R., Carvalho F., Carreaux A., Brito C., Pöntinen A., Korkeala H., Dos Santos N.M.S., Morais-Cabral J.H., Sousa S., Cabanes D.
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Research46(18):9338-9352, 2018. [Journal: Article] [CI: 33] [IF: 11,1]
DOI: 10.1093/nar/gky624 SCOPUS: 85054896319
Carvalho F., Sousa S., Cabanes D.
l-Rhamnosylation of wall teichoic acids promotes efficient surface association of Listeria monocytogenes virulence factors InlB and Ami through interaction with GW domains. Environmental Microbiology20(11):3941-3951, 2018. [Journal: Article] [CI: 28] [IF: 5,1]
DOI: 10.1111/1462-2920.14351 SCOPUS: 85056596957
Pombinho R., Camejo A., Vieira A., Reis O., Carvalho F., Almeida M.T., Pinheiro J.C., Sousa S., Cabanes D.
Listeria monocytogenes CadC regulates cadmium efflux and fine-tunes lipoprotein localization to escape the host immune response and promote infection. Journal of Infectious Diseases215(9):1468-1479, 2017. [Journal: Article] [CI: 24] [IF: 5,2]
DOI: 10.1093/infdis/jix118 SCOPUS: 85021919420
Pinheiro J., Reis O., Vieira A., Moura I.M., Moreno L.Z., Carvalho F., Pucciarelli M.G., García-del Portillo F., Sousa S., Cabanes D.
Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection. Virulence8(6):993-1004, 2017. [Journal: Article] [CI: 21] [IF: 3,9]
DOI: 10.1080/21505594.2016.1244589 SCOPUS: 84992702646
Carvalho F., Atilano M.L., Pombinho R., Covas G., Gallo R.L., Filipe S.R., Sousa S., Cabanes D.
L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane. PLoS Pathogens11(5):, 2015. [Journal: Article] [CI: 79] [IF: 7]
DOI: 10.1371/journal.ppat.1004919 SCOPUS: 84930354332
Lebreton A., Lakisic G., Job V., Fritsch L., Tham T.N., Camejo A., Matteï P.J., Regnault B., Nahori M.A., Cabanes D., Gautreau A., Ait-Si-Ali S., Dessen A., Cossart P., Bierne H.
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science331(6022):1319-1321, 2011. [Journal: Article] [CI: 165] [IF: 31,2]
DOI: 10.1126/science.1200120 SCOPUS: 79952515250
Camejo A., Buchrieser C., Couvé E., Carvalho F., Reis O., Ferreira P., Sousa S., Cossart P., Cabanes D.
In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection. PLoS Pathogens5(5):, 2009. [Journal: Article] [CI: 191] [IF: 9]
DOI: 10.1371/journal.ppat.1000449 SCOPUS: 67249147690
