Mónica Botelho

Metabesity

Associate Researcher

Monica C. Botelho has completed her PhD with Distinction in 2011 from the Faculty of Medicine of Porto University. She is the Head of Lab of Health Promotion and Chronic Diseases Unit of the National Institute of Health Dr. Ricardo Jorge at Porto, a premier health service organization in Portugal. She has published more than 50 papers, with 1370 citations, and an H Index of 24 (Google Scholar metrics). She has been serving as an editorial board member of the following journals: Frontiers in Cellular and Infection Microbiology, Frontiers in Parasitology, Frontiers in Medicine, Frontiers in Public Health, Journal of Integrated OMICS, Analytical Cellular Pathology and Current Cancer Therapy Reviews.

Research topics:

-Neglected Tropical Diseases associated Cancers and Infertility

-Molecular carcinogenesis of schistosome associated squamous cell carcinoma of the bladder with mouse experiments as models of carcinogenesis

-Effects of schistosoma-derived estrogenic molecules on cell lines and the accumulation and biodistribution of these molecules in animal models, and their possible carcinogenic effect

-Schistosomiasis associated catechol-estrogens as biomarkers of cancer and infertility

Selected Publications

Cardoso R., Lacerda P.C., Costa P.P., Machado A., Carvalho A., Bordalo A., Fernandes R., Soares R., Richter J., Alves H., Botelho M.C.,

Estrogen metabolism-associated CYP2D6 and IL6-174g/c polymorphisms in schistosoma haematobium infection. International Journal of Molecular Sciences18(12):, 2017. [Journal: Article] [CI: 6] [IF: 3,7]
DOI: 10.3390/ijms18122560 SCOPUS: 85036574880.

Botelho M.C., Machado A., Carvalho A., Vilaça M., Conceição O., Rosa F., Alves H., Richter J., Bordalo A.A.,

Schistosoma haematobium in Guinea-Bissau: unacknowledged morbidity due to a particularly neglected parasite in a particularly neglected country. Parasitology Research115(4):1567-1572, 2016. [Journal: Article] [CI: 12] [IF: 2,3]
DOI: 10.1007/s00436-015-4891-3 SCOPUS: 84954119883.

Botelho M.C., Alves H., Barros A., Rinaldi G., Brindley P.J., Sousa M.,

The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: The case of schistosomes. Trends in Parasitology31(6):246-250, 2015. [Journal: Review] [CI: 22] [IF: 7,3]
DOI: 10.1016/j.pt.2015.03.005 SCOPUS: 84930483034.

Santos J., Gouveia M.J., Vale N., De Lurdes Delgado M., Gonçalves A., Da Silva J.M.T., Oliveira C., Xavier P., Gomes P., Santos L.L., Lopes C., Barros A., Rinaldi G., Brindley P.J., Da Costa J.M.C., Sousa M., Botelho M.C.,

Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium. PLoS ONE9(5):, 2014. [Journal: Article] [CI: 24] [IF: 3,2]
DOI: 10.1371/journal.pone.0096774 SCOPUS: 84901327095.

Botelho M.C., Ribeiro R., Vale N., Oliveira P., Medeiros R., Lopes C., Machado J.C., Correia Da Costa J.M.,

Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncology Reports27(2):356-362, 2012. [Journal: Article] [CI: 19] [IF: 2,3]
DOI: 10.3892/or.2011.1552 SCOPUS: 84855754142.

Botelho M.C., Machado J.C., Brindley P.J., da Costa J.M.C.,

Targeting molecular signaling pathways of Schistosoma haematobium infection in bladder cancer. Virulence2(4):, 2011. [Journal: Review] [CI: 46] [IF: 2,3]
SCOPUS: 79960932496.

Botelho M.C., Oliveira P.A., Lopes C., Correia da Costa J.M., Machado J.C.,

Urothelial dysplasia and inflammation induced by Schistosoma haematobium total antigen instillation in mice normal urothelium. Urologic Oncology: Seminars and Original Investigations29(6):809-814, 2011. [Journal: Article] [CI: 40] [IF: 3,2]
DOI: 10.1016/j.urolonc.2009.09.017 SCOPUS: 81055133635.

Botelho M.C., Soares R., Vale N., Ribeiro R., Camilo V., Almeida R., Medeiros R., Gomes P., Machado J.C., Correia da Costa J.M.,

Schistosoma haematobium: Identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen receptor in mammalian cells. Experimental Parasitology126(4):526-535, 2010. [Journal: Article] [CI: 31] [IF: 1,9]
DOI: 10.1016/j.exppara.2010.06.012 SCOPUS: 79960934913.

Botelho M.C., Crespo M., Almeida A., Vieira P., Delgado M.L., Araujo L., Machado J.C., Correia da Costa J.M.,

Schistosoma haematobium and Schistosomiasis mansoni: Production of an estradiol-related compound detected by elisa. Experimental Parasitology122(3):250-253, 2009. [Journal: Article] [CI: 27] [IF: 1,8]
DOI: 10.1016/j.exppara.2009.04.001 SCOPUS: 65749109751.

Botelho M., Ferreira A.C., Oliveira M.J., Domingues A., Machado J.C., da Costa J.M.C.,

Schistosoma haematobium total antigen induces increased proliferation, migration and invasion, and decreases apoptosis of normal epithelial cells. International Journal for Parasitology39(10):1083-1091, 2009. [Journal: Article] [CI: 51] [IF: 3,8]
DOI: 10.1016/j.ijpara.2009.02.016 SCOPUS: 67649440716.