Alexandre Carmo
Cell Activation & Gene Expression
Group leader
I was born in Lisbon in 1964. Graduated in Biochemistry at the Faculty of Sciences of the University of Lisbon in 1987 and moved at the end of the year to Porto, where in January 1991 I concluded an M.Sc. in Immunology at the Abel Salazar Institute of the University of Porto, under the supervision of Maria de Sousa. In 1991 I went to the laboratory of Alan Williams at the Sir William Dunn School of Pathology, University of Oxford, having obtained my D.Phil. in Immunology from Wolfson College in 1995. In the beginning of 1997 I returned to Porto to work at the IBMC-Institute of Molecular and Cell Biology as a post-doc in the lab of Maria de Sousa, and in 2002 started the group of Cell Activation and Gene Expression. My research has focused on the study of T cell activation and signal transduction mechanisms, and their impact in inflammation and in the development of autoimmunity.
Selected Publications
Santos R.F., Oliveira L., Carmo A.M.,
Domingues R.G., Lago-Baldaia I., Pereira-Castro I., Fachini J.M., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J.R., Carmo A.M., Moreira A.,
Pereira C.B., Bocková M., Santos R.F., Santos A.M., de Araújo M.M., Oliveira L., Homola J., Carmo A.M.,
Da Glória V.G., De Araújo M.M., Santos A.M., Leal R., De Almeida S.F., Carmo A.M., Moreira A.,
Oliveira M.I., Gonçalves C.M., Pinto M., Fabre S., Santos A.M., Lee S.F., Castro M.A.A., Nunes R.J., Barbosa R.R., Parnes J.R., Yu C., Davis S.J., Moreira A., Bismuth G., Carmo A.M.,
Rollett A., Reiter T., Nogueira P., Cardinale M., Loureiro A., Gomes A., Cavaco-Paulo A., Moreira A., Carmo A.M., Guebitz G.M.,
Bamberger M., Santos A.M., Gonçalves C.M., Oliveira M.I., James J.R., Moreira A., Lozano F., Davis S.J., Carmo A.M.,
Pinto P.A.B., Henriques T., Freitas M.O., Martins T., Domingues R.G., Wyrzykowska P.S., Coelho P.A., Carmo A.M., Sunkel C.E., Proudfoot N.J., Moreira A.,
Fernandes R.A., Yu C., Carmo A.M., Evans E.J., Anton van der Merwe P., Davis S.J.,
Gonçalves C.M., Castro M.A.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M.,
Tuning T cell activation: The function of CD6 at the immunological synapse and in T cell responses. Current Drug Targets17(6):630-639, 2016. [Journal: Article] [CI: 37] [IF: 3,2]
DOI: 10.2174/1389450116666150531152439 SCOPUS: 84964055216.
DOI: 10.2174/1389450116666150531152439 SCOPUS: 84964055216.
Domingues R.G., Lago-Baldaia I., Pereira-Castro I., Fachini J.M., Oliveira L., Drpic D., Lopes N., Henriques T., Neilson J.R., Carmo A.M., Moreira A.,
CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. European Journal of Immunology46(6):1490-1503, 2016. [Journal: Article] [CI: 28] [IF: 4,2]
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630.
DOI: 10.1002/eji.201545663 SCOPUS: 84973661630.
Pereira C.B., Bocková M., Santos R.F., Santos A.M., de Araújo M.M., Oliveira L., Homola J., Carmo A.M.,
The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain. Frontiers in Immunology7(OCT):, 2016. [Journal: Article] [CI: 14] [IF: 6,4]
DOI: 10.3389/fimmu.2016.00416 SCOPUS: 84997514499.
DOI: 10.3389/fimmu.2016.00416 SCOPUS: 84997514499.
Da Glória V.G., De Araújo M.M., Santos A.M., Leal R., De Almeida S.F., Carmo A.M., Moreira A.,
T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1. Journal of Immunology193(1):391-399, 2014. [Journal: Article] [CI: 24] [IF: 4,9]
DOI: 10.4049/jimmunol.1400038 SCOPUS: 84903626125.
DOI: 10.4049/jimmunol.1400038 SCOPUS: 84903626125.
Oliveira M.I., Gonçalves C.M., Pinto M., Fabre S., Santos A.M., Lee S.F., Castro M.A.A., Nunes R.J., Barbosa R.R., Parnes J.R., Yu C., Davis S.J., Moreira A., Bismuth G., Carmo A.M.,
CD6 attenuates early and late signaling events, setting thresholds for T-cell activation. European Journal of Immunology42(1):195-205, 2012. [Journal: Article] [CI: 57] [IF: 5]
DOI: 10.1002/eji.201040528 SCOPUS: 84855225261.
DOI: 10.1002/eji.201040528 SCOPUS: 84855225261.
Rollett A., Reiter T., Nogueira P., Cardinale M., Loureiro A., Gomes A., Cavaco-Paulo A., Moreira A., Carmo A.M., Guebitz G.M.,
Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages. International Journal of Pharmaceutics427(2):460-466, 2012. [Journal: Article] [CI: 77] [IF: 3,5]
DOI: 10.1016/j.ijpharm.2012.02.028 SCOPUS: 84859105871.
DOI: 10.1016/j.ijpharm.2012.02.028 SCOPUS: 84859105871.
Bamberger M., Santos A.M., Gonçalves C.M., Oliveira M.I., James J.R., Moreira A., Lozano F., Davis S.J., Carmo A.M.,
A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of fyn kinase. Journal of Biological Chemistry286(35):30324-30336, 2011. [Journal: Article] [CI: 33] [IF: 4,8]
DOI: 10.1074/jbc.M111.230102 SCOPUS: 80052235105.
DOI: 10.1074/jbc.M111.230102 SCOPUS: 80052235105.
Pinto P.A.B., Henriques T., Freitas M.O., Martins T., Domingues R.G., Wyrzykowska P.S., Coelho P.A., Carmo A.M., Sunkel C.E., Proudfoot N.J., Moreira A.,
RNA polymerase II kinetics in polo polyadenylation signal selection. EMBO Journal30(12):2431-2444, 2011. [Journal: Article] [CI: 102] [IF: 9,2]
DOI: 10.1038/emboj.2011.156 SCOPUS: 79958859723.
DOI: 10.1038/emboj.2011.156 SCOPUS: 79958859723.
Fernandes R.A., Yu C., Carmo A.M., Evans E.J., Anton van der Merwe P., Davis S.J.,
What Controls T Cell Receptor Phosphorylation?. Cell142(5):668-669, 2010. [Journal: Letter] [CI: 34] [IF: 32,4]
DOI: 10.1016/j.cell.2010.08.018 SCOPUS: 77956167214.
DOI: 10.1016/j.cell.2010.08.018 SCOPUS: 77956167214.
Gonçalves C.M., Castro M.A.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M.,
Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily. Molecular Immunology46(13):2585-2596, 2009. [Journal: Article] [CI: 15] [IF: 3,2]
DOI: 10.1016/j.molimm.2009.05.006 SCOPUS: 67650569240.
DOI: 10.1016/j.molimm.2009.05.006 SCOPUS: 67650569240.