Alexandre Carmo
Cell Activation & Gene Expression
Group leader
I was born in Lisbon in 1964. Graduated in Biochemistry at the Faculty of Sciences of the University of Lisbon in 1987 and moved at the end of the year to Porto, where in January 1991 I concluded an M.Sc. in Immunology at the Abel Salazar Institute of the University of Porto, under the supervision of Maria de Sousa. In 1991 I went to the laboratory of Alan Williams at the Sir William Dunn School of Pathology, University of Oxford, having obtained my D.Phil. in Immunology from Wolfson College in 1995. In the beginning of 1997 I returned to Porto to work at the IBMC-Institute of Molecular and Cell Biology as a post-doc in the lab of Maria de Sousa, and in 2002 started the group of Cell Activation and Gene Expression. My research has focused on the study of T cell activation and signal transduction mechanisms, and their impact in inflammation and in the development of autoimmunity.
Selected Publications
Do J.s., Chen W.K., Hung Y.W., Arribas-Layton D., Lu C., Gu A., Montero E., Carmo A.M., Reijonen H.
CD318 expression defines a novel subset of human CD8+ regulatory T cells. Science Advances12(4):1-13, 2026. [Journal: Article] [IF: 13.9 (*)]
DOI: 10.1126/sciadv.adz4203 SCOPUS: 105028457533
Bicho D., Erlandsson M.C., Svensson D., Comas E., Silva M.C., Chandrasekaran V., Lundgren V.M.E., Santos R.F., Oliveira L., Bokarewa M.I., Carmo A.M.
CD5L insufficiency exacerbates skeletal joint damage in rheumatoid arthritis. Molecular Medicine32(1):, 2026. [Journal: Article] [IF: 8.3 (*)]
DOI: 10.1186/s10020-026-01456-x SCOPUS: 105037871035
Inácio D., Amado T., Pamplona A., Sobral D., Cunha C., Santos R.F., Oliveira L., Rouquié N., Carmo A.M., Lesourne R., Gomes A.Q., Silva-Santos B.
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation. Nature Immunology26(3):497-510, 2025. [Journal: Article] [CI: 11] [IF: 26.5]
DOI: 10.1038/s41590-024-02073-8 SCOPUS: 85217211196
Pereira J.L., Arede L., Ferreira F., Matos A., Pereira D., Santos R.F., Carmo A.M., Oliveira M.J., Machado J.C., Duarte D., dos Santos N.R.
Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma. Leukemia39(1):178-188, 2025. [Journal: Article] [CI: 1] [IF: 8.8]
DOI: 10.1038/s41375-024-02446-w SCOPUS: 85207331538
Oliveira L., Silva M.C., Gomes A.P., Santos R.F., Cardoso M.S., Nóvoa A., Luche H., Cavadas B., Amorim I., Gärtner F., Malissen B., Mallo M., Carmo A.M.
CD5L as a promising biological therapeutic for treating sepsis. Nature Communications15(1):, 2024. [Journal: Article] [CI: 25] [IF: 14.7 (*)]
DOI: 10.1038/s41467-024-48360-8 SCOPUS: 85193351776
Santos R.F., de Sousa Linhares A., Steinberger P., Davis S.J., Oliveira L., Carmo A.M.
The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling. Cell communication and signaling : CCS22(1):, 2024. [Journal: Article] [CI: 9] [IF: 8.2 (*)]
DOI: 10.1186/s12964-024-01658-y SCOPUS: 85194218997
Henriques S.N., Oliveira L., Santos R.F., Carmo A.M.
CD6-mediated inhibition of T cell activation via modulation of Ras. Cell communication and signaling : CCS20(1):, 2022. [Journal: Article] [CI: 18] [IF: 8,4]
DOI: 10.1186/s12964-022-00998-x SCOPUS: 85142255413
Cardoso M.S., Santos R.F., Almeida S., Sá M., Pérez-Cabezas B., Oliveira L., Tavares J., Carmo A.M.
Physical Interactions With Bacteria and Protozoan Parasites Establish the Scavenger Receptor SSC4D as a Broad-Spectrum Pattern Recognition Receptor. Frontiers in Immunology12:, 2021. [Journal: Article] [CI: 13] [IF: 8,8]
DOI: 10.3389/fimmu.2021.760770 SCOPUS: 85122481820
Freitas R.F., Basto A., Almeida S.C.P., Santos R.F., Gonçalves C.M., Corria-Osorio J., Carvalho T., Carmo A.M., Oliveira V.G., Leon K., Graca L.
Modulation of CD4 T cell function via CD6-targeting. EBioMedicine47:427-435, 2019. [Journal: Article] [CI: 11] [IF: 5,7]
DOI: 10.1016/j.ebiom.2019.08.008 SCOPUS: 85072256661
Gonçalves C.M., Henriques S.N., Santos R.F., Carmo A.M.
CD6, a rheostat-type signalosome that tunes T cell activation. Frontiers in Immunology9:, 2018. [Journal: Review] [CI: 51] [IF: 4,7]
DOI: 10.3389/fimmu.2018.02994 SCOPUS: 85059925855
CD318 expression defines a novel subset of human CD8+ regulatory T cells. Science Advances12(4):1-13, 2026. [Journal: Article] [IF: 13.9 (*)]
DOI: 10.1126/sciadv.adz4203 SCOPUS: 105028457533
Bicho D., Erlandsson M.C., Svensson D., Comas E., Silva M.C., Chandrasekaran V., Lundgren V.M.E., Santos R.F., Oliveira L., Bokarewa M.I., Carmo A.M.
CD5L insufficiency exacerbates skeletal joint damage in rheumatoid arthritis. Molecular Medicine32(1):, 2026. [Journal: Article] [IF: 8.3 (*)]
DOI: 10.1186/s10020-026-01456-x SCOPUS: 105037871035
Inácio D., Amado T., Pamplona A., Sobral D., Cunha C., Santos R.F., Oliveira L., Rouquié N., Carmo A.M., Lesourne R., Gomes A.Q., Silva-Santos B.
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation. Nature Immunology26(3):497-510, 2025. [Journal: Article] [CI: 11] [IF: 26.5]
DOI: 10.1038/s41590-024-02073-8 SCOPUS: 85217211196
Pereira J.L., Arede L., Ferreira F., Matos A., Pereira D., Santos R.F., Carmo A.M., Oliveira M.J., Machado J.C., Duarte D., dos Santos N.R.
Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma. Leukemia39(1):178-188, 2025. [Journal: Article] [CI: 1] [IF: 8.8]
DOI: 10.1038/s41375-024-02446-w SCOPUS: 85207331538
Oliveira L., Silva M.C., Gomes A.P., Santos R.F., Cardoso M.S., Nóvoa A., Luche H., Cavadas B., Amorim I., Gärtner F., Malissen B., Mallo M., Carmo A.M.
CD5L as a promising biological therapeutic for treating sepsis. Nature Communications15(1):, 2024. [Journal: Article] [CI: 25] [IF: 14.7 (*)]
DOI: 10.1038/s41467-024-48360-8 SCOPUS: 85193351776
Santos R.F., de Sousa Linhares A., Steinberger P., Davis S.J., Oliveira L., Carmo A.M.
The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling. Cell communication and signaling : CCS22(1):, 2024. [Journal: Article] [CI: 9] [IF: 8.2 (*)]
DOI: 10.1186/s12964-024-01658-y SCOPUS: 85194218997
Henriques S.N., Oliveira L., Santos R.F., Carmo A.M.
CD6-mediated inhibition of T cell activation via modulation of Ras. Cell communication and signaling : CCS20(1):, 2022. [Journal: Article] [CI: 18] [IF: 8,4]
DOI: 10.1186/s12964-022-00998-x SCOPUS: 85142255413
Cardoso M.S., Santos R.F., Almeida S., Sá M., Pérez-Cabezas B., Oliveira L., Tavares J., Carmo A.M.
Physical Interactions With Bacteria and Protozoan Parasites Establish the Scavenger Receptor SSC4D as a Broad-Spectrum Pattern Recognition Receptor. Frontiers in Immunology12:, 2021. [Journal: Article] [CI: 13] [IF: 8,8]
DOI: 10.3389/fimmu.2021.760770 SCOPUS: 85122481820
Freitas R.F., Basto A., Almeida S.C.P., Santos R.F., Gonçalves C.M., Corria-Osorio J., Carvalho T., Carmo A.M., Oliveira V.G., Leon K., Graca L.
Modulation of CD4 T cell function via CD6-targeting. EBioMedicine47:427-435, 2019. [Journal: Article] [CI: 11] [IF: 5,7]
DOI: 10.1016/j.ebiom.2019.08.008 SCOPUS: 85072256661
Gonçalves C.M., Henriques S.N., Santos R.F., Carmo A.M.
CD6, a rheostat-type signalosome that tunes T cell activation. Frontiers in Immunology9:, 2018. [Journal: Review] [CI: 51] [IF: 4,7]
DOI: 10.3389/fimmu.2018.02994 SCOPUS: 85059925855
