Where Ideas Grow
Fátima Macedo
Cell Activation & Gene Expression
Associate Researcher
Fatima Macedo started her scientific career at IPATIMUP. Subsequently she moved to Loyola University of Chicago to work on Tumor Immunology. She conducted her PhD studies, in Immunology, under the GABBA program at IBMC-ICBAS and Harvard University, graduating in 2006. In 2005 she took a full time position as an assistant Professor at Piaget Institute and later moved to Aveiro University (where she still works part time). It is with great pleasure that she shares her passion for science with students. At IBMC, in 2011, she got her first research project as principal investigator. Her team?s research interests are to identify sphingolipids important for the modulation of CD1 restricted T cell activation and understanding the role of this modulation in different pathological conditions.

Selected Publications

Pereira C.S., Pérez-Cabezas B., Ribeiro H., Maia M.L., Cardoso M.T., Dias A.F., Azevedo O., Ferreira M.F., Garcia P., Rodrigues E., Castro-Chaves P., Martins E., Aguiar P., Pineda M., Amraoui Y., Fecarotta S., Leão-Teles E., Deng S., Savage P.B., MacEdo M.F.,
Lipid antigen presentation by CD1b and CD1d in lysosomal storage disease patients. Frontiers in Immunology10(JUN):, 2019. [Journal: Article] [CI: 9] [IF: 5,1]
DOI: 10.3389/fimmu.2019.01264 SCOPUS: 85068479519.


Melum E., Jiang X., Baker K.D., Macedo M.F., Fritsch J., Dowds C.M., Wang J., Pharo A., Kaser A., Tan C., Pereira C.S., Kelly S.L., Duan J., Karlsen T.H., Exley M.A., Schütze S., Zajonc D.M., Merrill A.H., Schuchman E.H., Zeissig S., Blumberg R.S.,
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology20(12):1644-1655, 2019. [Journal: Article] [CI: 34] [IF: 20,5]
DOI: 10.1038/s41590-019-0504-0 SCOPUS: 85074348323.


Deng S., Kain L., Pereira C.S., Mata S., Macedo M.F., Bendelac A., Teyton L., Savage P.B.,
Psychosine variants as antigens for natural killer T cells. Chemical Science8(3):2204-2208, 2017. [Journal: Article] [CI: 6] [IF: 9,1]
DOI: 10.1039/c6sc04218j SCOPUS: 85014114931.


Pereira C.S., Sa-Miranda C., De Libero G., Mori L., Macedo M.F.,
Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner. European Journal of Immunology46(1):147-153, 2016. [Journal: Article] [CI: 14] [IF: 4,2]
DOI: 10.1002/eji.201545725 SCOPUS: 84953835270.


Pereira C.S., Ribeiro H., Macedo M.F.,
From lysosomal storage diseases to NKT cell activation and back. International Journal of Molecular Sciences18(3):, 2017. [Journal: Review] [CI: 15] [IF: 3,7]
DOI: 10.3390/ijms18030502 SCOPUS: 85014064972.


Pereira C.S., Azevedo O., Maia M.L., Dias A.F., Sa-Miranda C., Macedo M.F.,
Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease. Molecular Genetics and Metabolism108(4):241-248, 2013. [Journal: Article] [CI: 28] [IF: 2,8]
DOI: 10.1016/j.ymgme.2013.01.018 SCOPUS: 84875249971.


Macedo M.F., Quinta R., Pereira C.S., Sa Miranda M.C.,
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. Molecular Genetics and Metabolism106(1):83-91, 2012. [Journal: Article] [CI: 15] [IF: 2,8]
DOI: 10.1016/j.ymgme.2012.02.014 SCOPUS: 84860197221.