Where Ideas Grow
Mariana Resende
Collaborator
Mariana Resende is as PhD student. Her work focuses on the assembly of granulomas during mycobacterial infections. Although it has been believed that these structures provide protection, recent evidences raised the possibility that granulomas may provide a sanctuary to microbes. Hence is crucial to understand the inflammation type genesis and clarify its role in the protective immunity development.

Selected Publications

Resende M., Ferreira C.M., Barbosa A.M., Cardoso M.S., Sousa J., Saraiva M., Castro A.G., Appelberg R., Torrado E.,
Myeloid HIF-1a regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection. Immunology159(1):121-129, 2020. [Journal: Article] [CI: 10] [IF: 7,4]
DOI: 10.1111/imm.13131 SCOPUS: 85074809578.


Resende M., Cardoso M.S., Fróis-Martins R., Borges M., Jordan M.B., Castro A.G., Appelberg R.,
TNF-mediated compensatory immunity to mycobacterium avium in the absence of macrophage activation by IFN-γ. Journal of Immunology203(9):2451-2458, 2019. [Journal: Article] [CI: 3] [IF: 4,9]
DOI: 10.4049/jimmunol.1801594 SCOPUS: 85073667502.


Gomes A.C., Moreira A.C., Silva T., Neves J.V., Mesquita G., Almeida A.A., Barreira-Silva P., Fernandes R., Resende M., Appelberg R., Rodrigues P.N.S., Gomes M.S.,
IFN-γ-dependent reduction of erythrocyte life span leads to anemia during mycobacterial infection. Journal of Immunology203(9):2485-2496, 2019. [Journal: Article] [CI: 17] [IF: 4,9]
DOI: 10.4049/jimmunol.1900382 SCOPUS: 85073667610.


Resende M., Cardoso M.S., Ribeiro A.R., Flórido M., Borges M., Gil Castro A., Alves N.L., Cooper A.M., Appelberg R.,
Innate IFN-γ-Producing cells developing in the absence of IL-2 receptor common γ-chain. Journal of Immunology199(4):1429-1439, 2017. [Journal: Article] [CI: 7] [IF: 4,5]
DOI: 10.4049/jimmunol.1601701 SCOPUS: 85027298608.


Cardoso M.S., Silva T.M., Resende M., Appelberg R., Borges M.,
Lack of the transcription factor hypoxia-inducible factor 1a (HIF- 1a) in macrophages accelerates the necrosis of Mycobacterium avium-induced granulomas. Infection and Immunity83(9):3534-3544, 2015. [Journal: Article] [CI: 23] [IF: 3,6]
DOI: 10.1128/IAI.00144-15 SCOPUS: 84939546765.


Appelberg R., Moreira D., Barreira-Silva P., Borges M., Silva L., Dinis-Oliveira R.J., Resende M., Correia-Neves M., Jordan M.B., Ferreira N.C., Abrunhosa A.J., Silvestre R.,
The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ. Immunology145(4):498-507, 2015. [Journal: Article] [CI: 38] [IF: 4,1]
DOI: 10.1111/imm.12464 SCOPUS: 84936175105.


Resende M., Moreira D., Augusto J., Cunha J., Neves B., Cruz M.T., Estaquier J., Cordeiro-da-Silva A., Silvestre R.,
Leishmania-infected MHC class IIhigh dendritic cells polarize CD4+ T cells toward a nonprotective T-bet+ IFN-γ+ IL-10+ phenotype. Journal of Immunology191(1):262-273, 2013. [Journal: Article] [CI: 28] [IF: 5,4]
DOI: 10.4049/jimmunol.1203518 SCOPUS: 84879675210.


Moreira-Teixeira L., Resende M., Devergne O., Herbeuval J.P., Hermine O., Schneider E., Dy M., Cordeiro-da-Silva A., Leite-de-Moraes M.C.,
Rapamycin combined with TGF-ß converts human invariant NKT Cells into suppressive Foxp3 + regulatory cells. Journal of Immunology188(2):624-631, 2012. [Journal: Article] [CI: 46] [IF: 5,5]
DOI: 10.4049/jimmunol.1102281 SCOPUS: 84855999082.


Moreira-Teixeira L., Resende M., Coffre M., Devergne O., Herbeuval J.P., Hermine O., Schneider E., Rogge L., Ruemmele F.M., Dy M., Cordeiro-da-Silva A., Leite-de-Moraes M.C.,
Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells. Journal of Immunology186(10):5758-5765, 2011. [Journal: Article] [CI: 79] [IF: 5,8]
DOI: 10.4049/jimmunol.1003043 SCOPUS: 79956212653.