Rui Fernandes

Histology and Electron Microscopy

Platform Head

Rui Fernandes graduated in Biology in 1996 at the Faculty of Sciences of the University of Porto, and is completing his PhD at the Faculty of Medicine - FMUP / i3S.

His first contact with research was in 1995 with Professors Isabel Santos and Roberto Salema at Centro de Citologia Experimental. In 1996, he started working at Centro de Estudos de Paramiloidose, Hospital Santo António with Joana Palha and after he began a research project in the area of Familial Amyloidotic Polyneuropathy (FAP), with Professor Maria João Saraiva at the Institute for Molecular and Cell Biology (IBMC).

In 2002, he started a position as the head of the Advance Tissue Analysis Facility (ATAF) at the Institute for Molecular and Cell Biology, currently Histology and Electron Microscopy (HEMS). This service gives support on Transmission Electronic Microscopy (TEM), and Histology. The Facility provides both the equipment and technical support to researchers needing high level optical and TEM to tackle studies either of biological samples or in the area of material sciences. Besides the instruction for researchers, the Facility also offers training courses on master and PhD programs of University of Porto, as well as guided visits to high school students. Rui Fernandes has participated in numerous studies, namely: conventional Ultrastructure; immunoelectromicroscopy; elemental analysis EDX; STEM among others.

He has more than 60 publications in international peer reviewed journals.

Selected Publications

Sousa A., Rufino A.T., Fernandes R., Malheiro A., Carvalho F., Fernandes E., Freitas M.,

Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of ΔΨm and release of pro-inflammatory cytokines. Archives of Toxicology97(2):405-420, 2023. [Journal: Article] [CI: 2] [IF: 6,1 (*)]
DOI: 10.1007/s00204-022-03415-x SCOPUS: 85142511559.

de Sousa A., AbdElgawad H., Fidalgo F., Teixeira J., Matos M., Tamagnini P., Fernandes R., Figueiredo F., Azenha M., Teles L.O., Korany S.M., Alsherif E.A., Selim S., Beemster G.T.S., Asard H.,

Subcellular compartmentalization of aluminum reduced its hazardous impact on rye photosynthesis. Environmental Pollution315:, 2022. [Journal: Article] [CI: 2] [IF: 8,9]
DOI: 10.1016/j.envpol.2022.120313 SCOPUS: 85139853913.

Morais M., Machado V., Dias F., Figueiredo P., Palmeira C., Martins G., Fernandes R., Malheiro A.R., Mikkonen K.S., Teixeira A.L., Medeiros R.,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells. International Journal of Nanomedicine17:4321-4337, 2022. [Journal: Article] [CI: 9] [IF: 8]
DOI: 10.2147/IJN.S364862 SCOPUS: 85138245812.

Vilaça N., Bertão A.R., Prasetyanto E.A., Granja S., Costa M., Fernandes R., Figueiredo F., Fonseca A.M., De Cola L., Baltazar F., Neves I.C.,

Surface functionalization of zeolite-based drug delivery systems enhances their antitumoral activity in vivo. Materials Science and Engineering C120:, 2021. [Journal: Article] [CI: 20] [IF: 8,5]
DOI: 10.1016/j.msec.2020.111721 SCOPUS: 85097160036.

Aday S., Zoldan J., Besnier M., Carreto L., Saif J., Fernandes R., Santos T., Bernardino L., Langer R., Emanueli C., Ferreira L.,

Synthetic microparticles conjugated with VEGF₁₆₅ improve the survival of endothelial progenitor cells via microRNA-17 inhibition. Nature Communications8(1):, 2017. [Journal: Article] [CI: 35] [IF: 12,4]
DOI: 10.1038/s41467-017-00746-7 SCOPUS: 85030330994.

Santos S.D., Fernandes R., Saraiva M.J.,

The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems. Neurobiology of Aging31(2):280-289, 2010. [Journal: Article] [CI: 54] [IF: 6,6]
DOI: 10.1016/j.neurobiolaging.2008.04.001 SCOPUS: 71349088766.

Evangelista M.B., Hsiong S.X., Fernandes R., Sampaio P., Kong H.J., Barrias C.C., Salema R., Barbosa M.A., Mooney D.J., Granja P.L.,

Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix. Biomaterials28(25):3644-3655, 2007. [Journal: Article] [CI: 141] [IF: 6,3]
DOI: 10.1016/j.biomaterials.2007.04.028 SCOPUS: 34249870130.

Palha J.A., Ballinari D., Amboldi N., Cardoso I., Fernandes R., Bellotti V., Merlini G., Saraiva M.J.,

4'-iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. American Journal of Pathology156(6):1919-1925, 2000. [Journal: Article] [CI: 56] [IF: 7]
DOI: 10.1016/S0002-9440(10)65065-1 SCOPUS: 0033872046.