Where Ideas Grow
Rui Fernandes
Platform Head

Rui Fernandes graduated in Biology in 1996 at Faculty of Sciences, University of Porto. His first contact with research was in 1995 with Professors Isabel Santos and Roberto Salema at ?Centro de Citologia Experimental?. In 1996, he started working at ?Centro de Estudos de Paramiloidose, Hospital Santo António? with Joana Palha and after he began a research project in the area of Familial Amyloidotic Polyneuropathy (FAP), with Professor Maria João Saraiva at the Institute for Molecular and Cell Biology (IBMC).

In 2002, he started a position as the head of the Advance Tissue Analysis Facility (ATAF) at the Institute for Molecular and Cell Biology.

Currently, this facility is called Histology and Electron Microscopy (HEMS). This service gives support on Transmission Electronic Microscopy (TEM), and Histology.

The Facility provides both the equipment and technical support to researchers needing high level optical and TEM to tackle studies either of biological samples or in the area of material sciences.

Besides the instruction for researchers, the Facility also offers training courses on master and PhD programs of University of Porto, as well as guided visits to high school students.

Rui Fernandes has participated in numerous studies, namely: conventional Ultrastructure; immunoelectromicroscopy; elemental analysis ? EDS; STEM, among others.

He has more than 35 publications in international peer reviewed journals.

Selected Publications

Aday S., Zoldan J., Besnier M., Carreto L., Saif J., Fernandes R., Santos T., Bernardino L., Langer R., Emanueli C., Ferreira L.,
Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition. Nature Communications8(1):, 2017. [Journal: Article] [CI: 20] [IF: 12,4]
DOI: 10.1038/s41467-017-00746-7 SCOPUS: 85030330994.

Inácio Â.S., Domingues N.S., Nunes A., Martins P.T., Moreno M.J., Estronca L.M., Fernandes R., Moreno A.J.M., Borrego M.J., Gomes J.P., Vaz W.L.C., Vieira O.V.,
Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: Mechanisms of action and clinical implications in antibacterial prophylaxis. Journal of Antimicrobial Chemotherapy71(3):641-654, 2016. [Journal: Article] [CI: 42] [IF: 5,1]
DOI: 10.1093/jac/dkv405 SCOPUS: 84960839711.

Pinheiro A.M., Carreira A., Rollo F., Fernandes R., Ferreira R.B., Monteiro S.A.,
Blad-containing oligomer fungicidal activity on human pathogenic yeasts. From the outside to the inside of the target cell. Frontiers in Microbiology7(NOV):, 2016. [Journal: Article] [CI: 7] [IF: 4,1]
DOI: 10.3389/fmicb.2016.01803 SCOPUS: 85006725797.

Montani L., Buerki-Thurnherr T., de Faria J.P., Pereira J.A., Dias N.G., Fernandes R., Gonçalves A.F., Braun A., Benninger Y., Böttcher R.T., Costell M., Nave K.A., Franklin R.J.M., Meijer D., Suter U., Relvas J.B.,
Profilin 1 is required for peripheral nervous system myelination. Development141(7):1553-1561, 2014. [Journal: Article] [CI: 28] [IF: 6,5]
DOI: 10.1242/dev.101840 SCOPUS: 84896286838.

Santos S.D., Fernandes R., Saraiva M.J.,
The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems. Neurobiology of Aging31(2):280-289, 2010. [Journal: Article] [CI: 46] [IF: 6,6]
DOI: 10.1016/j.neurobiolaging.2008.04.001 SCOPUS: 71349088766.

Evangelista M.B., Hsiong S.X., Fernandes R., Sampaio P., Kong H.J., Barrias C.C., Salema R., Barbosa M.A., Mooney D.J., Granja P.L.,
Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix. Biomaterials28(25):3644-3655, 2007. [Journal: Article] [CI: 130] [IF: 6,3]
DOI: 10.1016/j.biomaterials.2007.04.028 SCOPUS: 34249870130.

Mendes Sousa M.M., Cardoso I., Fernandes R., Guimarães A., João Saraiva M.,
Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: Evidence for toxicity of nonfibrillar aggregates. American Journal of Pathology159(6):1993-2000, 2001. [Journal: Article] [CI: 300] [IF: 7,1]
DOI: 10.1016/S0002-9440(10)63050-7 SCOPUS: 0035180285.

Palha J.A., Ballinari D., Amboldi N., Cardoso I., Fernandes R., Bellotti V., Merlini G., Saraiva M.J.,
4'-iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. American Journal of Pathology156(6):1919-1925, 2000. [Journal: Article] [CI: 52] [IF: 7]
DOI: 10.1016/S0002-9440(10)65065-1 SCOPUS: 0033872046.