Ana Magalhães

Glycobiology in Cancer

Associate Researcher

Ana Magalhães graduated in Biochemistry (2005) and holds a PhD in Biomedicine (2011) by University of Porto. She got trained in proteomics at the BRC-Centre of Excellence of the European Union (Hungary), in Proximity Ligation Assays at Uppsala University (Sweden), in cancer glycobiology at the Institute of Molecular Pathology and Immunology of University of Porto (Portugal) and in bacterial adhesion and pathogen adaptation at Umea University (Sweden).
Ana co-authored more than 50 scientific articles, including highly prestigious journals such as Cancer Cell, PNAS, Nature Cell Biology, Developmental Cell and J Biol Chem. Her publications have received more than 2400 citations (H-index 29). She has successfully complete the supervision of 4 PhD and 6 MSc students, as main or co-supervisor. All these dissertations articulate fundamental and clinical research.
At present, Ana is an Assistant Professor of Biochemistry at ICBAS- Scholl of Medicine and Biomedical Science and Investigator at i3S - University of Porto and her main research interests are focused on the mechanistic roles of proteoglycans in cancer-extracellular matrix dynamics and cell communication and signaling.

Selected Publications

Poças J., Marques C., Gomes C., Otake A.H., Pinto F., Ferreira M., Silva T., Faria-Ramos I., Matos R., Ribeiro A.R., Senra E., Cavadas B., Batista S., Maia J., Macedo J.A., Lima L., Afonso L.P., Ferreira J.A., Santos L.L., Polónia A., Osório H., Belting M., Reis C.A., Costa-Silva B., Magalhães A.,

Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival. Proceedings of the National Academy of Sciences of the United States of America120(20):, 2023. [Journal: Article] [CI: 4] [IF: 11,1 (*)]
DOI: 10.1073/pnas.2214853120 SCOPUS: 85158135443.

Marques C., Poças J., Gomes C., Faria-Ramos I., Reis C.A., Vivès R.R., Magalhães A.,

Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion. Journal of Biological Chemistry298(11):, 2022. [Journal: Article] [CI: 3] [IF: 4,8]
DOI: 10.1016/j.jbc.2022.102546 SCOPUS: 85142940251.

Magalhães A., Duarte H.O., Reis C.A.,

The role of O-glycosylation in human disease. Molecular Aspects of Medicine79:, 2021. [Journal: Article] [CI: 47] [IF: 16,3]
DOI: 10.1016/j.mam.2021.100964 SCOPUS: 85103339673.

Magalhães A., Duarte H.O., Reis C.A.,

Glycans and Cancer. Encyclopedia of Cell Biology: Volume 1-6, Second Edition4:373-384, 2022. [Book: Book Chapter]
DOI: 10.1016/B978-0-12-821618-7.00019-5 SCOPUS: 85158933728.

Marques C., Reis C.A., Vivès R.R., Magalhães A.,

Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression. Frontiers in Oncology11:, 2021. [Journal: Review] [CI: 32] [IF: 5,7]
DOI: 10.3389/fonc.2021.778752 SCOPUS: 85120413881.

Nogueira-Rodrigues J., Leite S.C., Pinto-Costa R., Sousa S.C., Luz L.L., Sintra M.A., Oliveira R., Monteiro A.C., Pinheiro G.G., Vitorino M., Silva J.A., Simão S., Fernandes V.E., Provazník J., Benes V., Cruz C.D., Safronov B.V., Magalhães A., Reis C.A., Vieira J., Vieira C.P., Tiscórnia G., Araújo I.M., Sousa M.M.,

Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection. Developmental Cell57(4):440-450.e7, 2022. [Journal: Article] [CI: 19] [IF: 11,8]
DOI: 10.1016/j.devcel.2021.12.008 SCOPUS: 85123830565.

Fonseca K.L., Maceiras A.R., Matos R., Simoes-Costa L., Sousa J., Cá B., Barros L., Fernandes A.I., Mereiter S., Reis R., Gomes J., Tapia G., Rodríguez-Martínez P., Martín-Céspedes M., Vashakidze S., Gogishvili S., Nikolaishvili K., Appelberg R., Gärtner F., Rodrigues P.N.S., Vilaplana C., Reis C.A., Magalhães A., Saraiva M.,

Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils. Mucosal Immunology13(5):836-848, 2020. [Journal: Article] [CI: 15] [IF: 7,3]
DOI: 10.1038/s41385-020-0277-7 SCOPUS: 85082197621.

Magalhães A., Duarte H.O., Reis C.A.,

Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer Cell31(6):733-735, 2017. [Journal: Short Survey] [CI: 108] [IF: 22,8]
DOI: 10.1016/j.ccell.2017.05.012 SCOPUS: 85020642808.

Magalhães A., Marcos-Pinto R., Nairn A.V., dela Rosa M., Ferreira R.M., Junqueira-Neto S., Freitas D., Gomes J., Oliveira P., Santos M.R., Marcos N.T., Xiaogang W., Figueiredo C., Oliveira C., Dinis-Ribeiro M., Carneiro F., Moremen K.W., David L., Reis C.A.,

Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. Biochimica et Biophysica Acta - Molecular Basis of Disease1852(9):1928-1939, 2015. [Journal: Article] [CI: 63] [IF: 5,2]
DOI: 10.1016/j.bbadis.2015.07.001 SCOPUS: 84940455366.

Magalhães A., Gomes J., Ismail M.N., Haslam S.M., Mendes N., Osório H., David L., Le Pendu J., Haas R., Dell A., Borén T., Reis C.A.,

Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa. Glycobiology19(12):1525-1536, 2009. [Journal: Article] [CI: 89] [IF: 3,9]
DOI: 10.1093/glycob/cwp131 SCOPUS: 71049182586.