I am a PhD candidate with a strong background in entrepreneurship and management, pursuing research on the molecular mechanisms governing invasive cell migration. My work focuses on cell motility, cytoskeletal dynamics, and Rho GTPase signalling, using the Drosophila melanogaster egg chamber as an in vivo model. During oogenesis, a small cluster of migratory border cells undergoes highly coordinated collective movement that recapitulates key features of cancer cell invasion. By dissecting the regulatory networks controlling cytoskeletal organisation and force generation in this system, my research aims to identify conserved mechanisms that are directly relevant to human disease. In parallel, I apply skills in data analysis, process optimisation, and computational troubleshooting to enhance experimental efficiency and reproducibility.
Selected Publications
Breast cancer: Insights in disease and influence of drug methotrexate. RSC Medicinal Chemistry11(6):646-664, 2020. [Journal: Review] [CI: 63]
DOI: 10.1039/d0md00051e SCOPUS: 85089575777
Yang V., Pedrosa S.S., Fernandes R., Maurício A.C., Koksch B., Gärtner F., Amorim I., Vale N.
Synthesis of PEGylated methotrexate conjugated with a novel CPP6, in sillico structural insights and activity in MCF-7 cells. Journal of Molecular Structure1192:201-207, 2019. [Journal: Article] [CI: 5] [IF: 2,5]
DOI: 10.1016/j.molstruc.2019.04.118 SCOPUS: 85065813795
Silva F., Huang Y., Yang V., Mu X., Shi Q., Antunes A.
Transcriptomic characterization of the south american freshwater stingray potamotrygon motoro venom apparatus. Toxins10(12):, 2018. [Journal: Article] [CI: 15] [IF: 3,9]
DOI: 10.3390/toxins10120544 SCOPUS: 85058873833
