José Mateus

Neuroengineering and Computational Neuroscience

Junior Researcher

I got my BSc in Biomedical Sciences and MSc in Molecular Biomedicine at the University of Aveiro in 2013 and 2015. In 2016, I was accepted in the BiotechHealth Doctoral Programme from Instituto de Ciências Biomédicas Abel Salazar (ICBAS) and started working on my PhD project at INEB-i3S in 2017. I completed my PhD at the beginning of 2022, within the Neuroengineering and Computational Neuroscience (NCN) group, under the supervision of Paulo Aguiar (i3S) and Mónica Sousa (i3S) and in collaboration with the lab of János Vörös (ETH Zurich, Switzerland). This work has led to the publication of 8 international peer-reviewed publications. I am currently a post-doc researcher at the NCN group.

I am particularly interested in building neuronal circuits in vitro with realistic connectivity, which can be probed with advanced electrophysiology and imaging techniques.

Selected Publications

Mateus J.C., Weaver S., Van Swaay D., Renz A.F., Hengsteler J., Aguiar P., Vörös J.,

Nanoscale Patterning of in Vitro Neuronal Circuits. ACS Nano16(4):5731-5742, 2022. [Journal: Article] [CI: 5] [IF: 17,1]
DOI: 10.1021/acsnano.1c10750 SCOPUS: 85129103498.

Girardin S., Clément B., Ihle S.J., Weaver S., Petr J.B., Mateus J.C., Duru J., Krubner M., Forró C., Ruff T., Fruh I., Müller M., Vörös J.,

Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings. Lab on a Chip22(7):1386-1403, 2022. [Journal: Article] [CI: 7] [IF: 6,1]
DOI: 10.1039/d1lc01110c SCOPUS: 85127217072.

Neto E., Leitão L., Mateus J.C., Sousa D.M., Alves C.J., Aroso M., Monteiro A.C., Conceição F., Oreffo R.O.C., West J., Aguiar P., Lamghari M.,

Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling. Cell and Bioscience12(1):, 2022. [Journal: Article] [CI: 1] [IF: 7,5]
DOI: 10.1186/s13578-022-00864-w SCOPUS: 85135937935.

Mateus J.C., Lopes C.D.F., Aroso M., Costa A.R., Gerós A., Meneses J., Faria P., Neto E., Lamghari M., Sousa M.M., Aguiar P.,

Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures. Journal of Neural Engineering18(6):, 2021. [Journal: Article] [CI: 5] [IF: 5]
DOI: 10.1088/1741-2552/ac41db SCOPUS: 85122868659.

Costa A.R., Sousa S.C., Pinto-Costa R., Mateus J.C., Lopes C.D.F., Costa A.C., Rosa D., Machado D., Pajuelo L., Wang X., Zhou F.Q., Pereira A.J., Sampaio P., Rubinstein B.Y., Pinto I.M., Lampe M., Aguiar P., Sousa M.M.,

The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction. eLife9:, 2020. [Journal: Article] [CI: 37] [IF: 8,1]
DOI: 10.7554/eLife.55471 SCOPUS: 85082635132.

Heiney K., Mateus J.C., Lopes C.D.F., Neto E., Lamghari M., Aguiar P.,

µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms. Scientific Reports9(1):, 2019. [Journal: Article] [CI: 6] [IF: 4]
DOI: 10.1038/s41598-019-42148-3 SCOPUS: 85064068131.

Mateus J.C., Lopes C.D.F., Cerquido M., Leitão L., Leitão D., Cardoso S., Ventura J., Aguiar P.,

Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis. Journal of Neural Engineering16(3):, 2019. [Journal: Article] [CI: 10] [IF: 4,1]
DOI: 10.1088/1741-2552/ab0b86 SCOPUS: 85065810756.

Lopes C.D.F., Mateus J.C., Aguiar P.,

Interfacing microfluidics with microelectrode arrays for studying neuronal communication and axonal signal propagation. Journal of Visualized Experiments2018(142):, 2018. [Journal: Article] [CI: 9] [IF: 1,1]
DOI: 10.3791/58878 SCOPUS: 85058915521.