Where Ideas grow
Carla Oliveira
Principal Researcher

Carla Oliveira, BSc, PhD

2015-present       Group Leader/Principal Investigator (tenure), Expression Regulation in Cancer Group, i3S Porto, PT

2013-present       Group Leader/Principal Investigator (tenure), Expression Regulation in Cancer Group, Ipatimup, Porto, PT

2013-present       Co-founder, Scientific Head and CEO, Bioinf2Bio Bioinformatics Company, Porto, PT

2006-present       Affiliated Professor, Dept. Pathology, Fac. Medicine, Univ. Porto, PT

2005-present       Consultant for gastric-cancer related syndromes, IPATIMUP Diagnostics, Porto, PT

2011-2012           Invited researcher, Max Planck Institute for Developmental Biology, Tubingen, DE (E. Isaurralde Lab)

2008-2012            Junior Group Leader, Ipatimup, Porto, PT (Ciência 2008 – FCT)   

2005-2008           Team Leader, Ipatimup, Porto, PT (Agência de Inovação - FCT)   

2004-2005            Post-doc Researcher, Univ. British Columbia, Vancouver, CA (D. Huntsman Lab)

2002-2003            Post-doc Researcher, Ipatimup, Porto, PT (R. Seruca Lab) & INSERM, Paris, FR (R. Hamelin Lab)

March-2002         GABBA PhD in Human Biology, Fac. Medicine, Univ. Porto, PT

2001-2002           Visiting Ph.D. student, Ipatimup, PT (R. Seruca Lab)

1999-2000           Ph.D. student, CIMR - Cambridge Institute for Medical Research (C. Caldas Lab), Cambridge Univ., UK

1997-1998            Research Fellowship recipient, Ipatimup-Institute of Molecular Pathology and Immunology UPorto, PT

1991-1996            Biochemistry Degree, Fac. Science and Technology, Univ. Coimbra, PT


In March2021

H-INDEX = 49 (SCOPUS/ResearcherID) or 60 (GoogleScholar) 

PUBLICATIONS: 152 peer-reviewed articles with >10.000 (SCOPUS) or >15000 citations (GoogleScholar) in the fields of Human Genetics and Molecular Oncology; 

Accumulated Impact Factor: >1.000,00

C. Oliveira is recognized internationally for her work in E-cadherin/CDH1-related diseases and hereditary cancer. She disclosed novel germline causes of Hereditary Gastrointestinal Cancer and defined somatic events in tumours with impact for patient management and therapy.

Her main scientific aim is to disclose the missing heritability in Hereditary Gastric Cancer. For this, her team is exploring the whole genome, with particular emphasis in the noncoding genome. She also aims at finding biomarkers with clinical utility for earlier detection of sporadic and hereditary gastric cancer and to disclose actionable genotype-phenotype relationships in these diseases. The social and economic impact of hereditary cancer is a transversal aspect in her research and she privileges the interaction with Patient’s associations, such as EVITA. 

C. Oliveira has been a PI of 23 projects funded with >3.5M€ and team member in 17 projects with equivalent total budget. She independently raised additional 2.5M€ for human resources. She was invited speaker in >100 National and International conferences; she is Scientific and Executive Committee Member of the European Society of Human Genetics and its Portuguese sister society; National Representative of the European Reference Network ERN-GENTURIS on genetic tumour risk syndromes, and; the head the Hereditary Diffuse Gastric Cancer branch of the SolveRD (Solving Rare diseases) EU-Project. She is regular reviewer of National and International fellowship and grant applications. She successfully supervised 13 Masters and 13 PhD students to completion, 10 post-docs and recruited 3 junior project leaders (iFCT) for her team.

C. Oliveira’s group has also gained expertise and visibility in genomics and bioinformatics, due to active participation in international consortia and large European Projects including the European-wide research project SOLVE-RD – Solve Rare diseases; the Consortium GEUVADIS and GTEx; Several COST actions, as well as the Marie Skłodowska-Curie Innovative Training Networks ITN TRAIN-EV. The group has relevant roles in management and executive functions in the GenomePT National Infrastructure for genome sequencing and the 1 Million European Genomes project. Her team is multidisciplinary with strong background in oncobiology and genetics, and supported by technical expertise in molecular and cellular biology, NGS, bioinformatics and a strong link with hospitals and clinical professionals. 

Selected Publications

Oliveira C., Pinheiro H., Figueiredo J., Seruca R., Carneiro F.,
Familial gastric cancer: Genetic susceptibility, pathology, and implications for management. The Lancet Oncology16(2):e60-e70, 2015. [Journal: Review] [CI: 154] [IF: 26,5]
DOI: 10.1016/S1470-2045(14)71016-2 SCOPUS: 84921774175.

Corso G., Carvalho J., Marrelli D., Vindigni C., Carvalho B., Seruca R., Roviello F., Oliveira C.,
Somatic mutations and deletions of the e-cadherin gene predict poor survival of patients with gastric cancer. Journal of Clinical Oncology31(7):868-875, 2013. [Journal: Article] [CI: 104] [IF: 17,9]
DOI: 10.1200/JCO.2012.44.4612 SCOPUS: 84875753760.

Pinheiro H., Bordeira-Carriço R., Seixas S., Carvalho J., Senz J., Oliveira P., Inácio P., Gusmão L., Rocha J., Huntsman D., Seruca R., Oliveira C.,
Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. Human Molecular Genetics19(5):943-952, 2010. [Journal: Article] [CI: 72] [IF: 8,1]
DOI: 10.1093/hmg/ddp537 SCOPUS: 77950533734.

Oliveira C., Senz J., Kaurah P., Pinheiro H., Sanges R., Haegert A., Corso G., Schouten J., Fitzgerald R., Vogelsang H., Keller G., Dwerryhouse S., Grimmer D., Chin S.F., Yang H.K., Jackson C.E., Seruca R., Roviello F., Stupka E., Caldas C., Huntsman D.,
Germline CDH1 deletions in hereditary diffuse gastric cancer families. Human Molecular Genetics18(9):1545-1555, 2009. [Journal: Article] [CI: 141] [IF: 7,4]
DOI: 10.1093/hmg/ddp046 SCOPUS: 64549109715.

Oliveira C., Sousa S., Pinheiro H., Karam R., Bordeira-Carriço R., Senz J., Kaurah P., Carvalho J., Pereira R., Gusmão L., Wen X., Cipriano M.A., Yokota J., Carneiro F., Huntsman D., Seruca R.,
Quantification of Epigenetic and Genetic 2nd Hits in CDH1 During Hereditary Diffuse Gastric Cancer Syndrome Progression. Gastroenterology136(7):2137-2148, 2009. [Journal: Article] [CI: 121] [IF: 12,9]
DOI: 10.1053/j.gastro.2009.02.065 SCOPUS: 66149108352.

Ferreira D.A., Rothbauer M., Conde J.P., Ertl P., Oliveira C., Granja P.L.,
A Fast Alternative to Soft Lithography for the Fabrication of Organ-on-a-Chip Elastomeric-Based Devices and Microactuators. Advanced Science:, 2021. [Journal: Article] [IF: 15,8 (*)]
DOI: 10.1002/advs.202003273 SCOPUS: 85100571451.

Blair V.R., McLeod M., Carneiro F., Coit D.G., D'Addario J.L., van Dieren J.M., Harris K.L., Hoogerbrugge N., Oliveira C., van der Post R.S., Arnold J., Benusiglio P.R., Bisseling T.M., Boussioutas A., Cats A., Charlton A., Schreiber K.E.C., Davis J.L., Pietro M.d., Fitzgerald R.C., Ford J.M., Gamet K., Gullo I., Hardwick R.H., Huntsman D.G., Kaurah P., Kupfer S.S., Latchford A., Mansfield P.F., Nakajima T., Parry S., Rossaak J., Sugimura H., Svrcek M., Tischkowitz M., Ushijima T., Yamada H., Yang H.K., Claydon A., Figueiredo J., Paringatai K., Seruca R., Bougen-Zhukov N., Brew T., Busija S., Carneiro P., DeGregorio L., Fisher H., Gardner E., Godwin T.D., Holm K.N., Humar B., Lintott C.J., Monroe E.C., Muller M.D., Norero E., Nouri Y., Paredes J., Sanches J.M., Schulpen E., Ribeiro A.S., Sporle A., Whitworth J., Zhang L., Reeve A.E., Guilford P.,
Hereditary diffuse gastric cancer: updated clinical practice guidelines. The Lancet Oncology21(8):e386-e397, 2020. [Journal: Review] [CI: 11] [IF: 33,8 (*)]
DOI: 10.1016/S1470-2045(20)30219-9 SCOPUS: 85088930288.

Rocha S., Carvalho J., Oliveira P., Voglstaetter M., Schvartz D., Thomsen A.R., Walter N., Khanduri R., Sanchez J.C., Keller A., Oliveira C., Nazarenko I.,
3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles. Advanced Science6(4):, 2019. [Journal: Article] [CI: 18] [IF: 15,8]
DOI: 10.1002/advs.201800948 SCOPUS: 85058843482.

Santos M., Fidalgo A., Varanda A.S., Oliveira C., Santos M.A.S.,
tRNA Deregulation and Its Consequences in Cancer. Trends in Molecular Medicine25(10):853-865, 2019. [Journal: Review] [CI: 18] [IF: 11,1]
DOI: 10.1016/j.molmed.2019.05.011 SCOPUS: 85067658954.

Rocha S., Basto A.P., Ijsselsteijn M.E., Teles S.P., Azevedo M.M., Gonçalves G., Gullo I., Almeida G.M., Maqueda J.J., Oliveira M.I., Carneiro F., Barata J.T., Graça L., de Miranda N.F.C.C., Carvalho J., Oliveira C.,
Immunophenotype of gastric tumors unveils a pleiotropic role of regulatory t cells in tumor development. Cancers13(3):1-20, 2021. [Journal: Article] [IF: 6,1 (*)]
DOI: 10.3390/cancers13030421 SCOPUS: 85099977279.