Delfim Duarte

Basic & Clinical Research on Iron Biology

Project Leader

I am physician-scientist interested in understanding ecological interactions between malignant and non-malignant cells and their surrounding microenvironments. I have a particular interest in bone marrow (BM) niches, leukemia, hematopoiesis, vascular biology and intravital microscopy.

I have previously performed research in the fields of angiogenesis, inflammation and cell microparticles in Raquel Soares' lab (FMUP). In 2014, I moved to Cristina Lo Celso's lab (Imperial College London; GABBA program) where I studied the interaction between acute leukaemic cells and BM niches. As part of my studies, I reported that T-ALL is niche-agnostic and extremely motile (Hawkins* and Duarte* et al. Nature 2016). I have also investigated acute leukemia cell in vivo migration at different disease stages (Immunology and Cell Biology, 2019) and the disruption of HSC-supporting niches in AML (Duarte et al. Cell Stem Cell. 2018; Akinduro et al. Nat Comms. 2018). In 2017, I was part of the European Hematology Association (EHA)-American Society Hematology (ASH) Translational Research Training in Hematology (TRTH) program.

I am currently developing my clinical activity at IPO-Porto and performing translational research ai i3S. My research program is currently funded by EHA, NBF, Fundação Amélia de Mello and SPH.

Selected Publications

Duarte D., Hawkins E.D., Akinduro O., Ang H., De Filippo K., Kong I.Y., Haltalli M., Ruivo N., Straszkowski L., Vervoort S.J., McLean C., Weber T.S., Khorshed R., Pirillo C., Wei A., Ramasamy S.K., Kusumbe A.P., Duffy K., Adams R.H., Purton L.E., Carlin L.M., Lo Celso C.,

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML. Cell Stem Cell22(1):64-77.e6, 2018. [Journal: Article] [CI: 59] [IF: 21,5]
DOI: 10.1016/j.stem.2017.11.006 SCOPUS: 85038843065.

Hawkins E.D., Duarte D., Akinduro O., Khorshed R.A., Passaro D., Nowicka M., Straszkowski L., Scott M.K., Rothery S., Ruivo N., Foster K., Waibel M., Johnstone R.W., Harrison S.J., Westerman D.A., Quach H., Gribben J., Robinson M.D., Purton L.E., Bonnet D., Lo Celso C.,

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments. Nature538(7626):518-522, 2016. [Journal: Article] [CI: 84] [IF: 40,1]
DOI: 10.1038/nature19801 SCOPUS: 84994005268.

Duarte D., Amarteifio S., Ang H., Kong I.Y., Ruivo N., Pruessner G., Hawkins E.D., Lo Celso C.,

Defining the inαvivo characteristics of acute myeloid leukemia cells behavior by intravital imaging. Immunology and Cell Biology97(2):229-235, 2019. [Journal: Article] [CI: 6] [IF: 3,7]
DOI: 10.1111/imcb.12216 SCOPUS: 85058390194.

Duarte D., Hawkins E.D., Lo Celso C.,

The interplay of leukemia cells and the bone marrow microenvironment. Blood131(14):1507-1511, 2018. [Journal: Review] [CI: 17] [IF: 16,6]
DOI: 10.1182/blood-2017-12-784132 SCOPUS: 85047608213.

Akinduro O., Weber T.S., Ang H., Haltalli M.L.R., Ruivo N., Duarte D., Rashidi N.M., Hawkins E.D., Duffy K.R., Lo Celso C.,

Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space. Nature Communications9(1):, 2018. [Journal: Article] [CI: 13] [IF: 11,9]
DOI: 10.1038/s41467-017-02376-5 SCOPUS: 85041639415.

Tjin G., Flores-Figueroa E., Duarte D., Straszkowski L., Scott M., Khorshed R.A., Purton L.E., Lo Celso C.,

Imaging methods used to study mouse and human HSC niches: Current and emerging technologies. Bone119:19-35, 2019. [Journal: Review] [CI: 4] [IF: 4,1]
DOI: 10.1016/j.bone.2018.04.022 SCOPUS: 85046379604.

Duarte D., Taveira-Gomes T., Sokhatska O., Palmares C., Costa R., Negrão R., Guimarães J.T., Delgado L., Soares R., Moreira A.,

Increased circulating platelet microparticles as a potential biomarker in asthma. Allergy: European Journal of Allergy and Clinical Immunology68(8):1073-1075, 2013. [Journal: Article] [CI: 26] [IF: 6]
DOI: 10.1111/all.12190 SCOPUS: 84883181922.

Khorshed R.A., Hawkins E.D., Duarte D., Scott M.K., Akinduro O.A., Rashidi N.M., Spitaler M., Lo Celso C.,

Automated Identification and Localization of Hematopoietic Stem Cells in 3D Intravital Microscopy Data. Stem Cell Reports5(1):139-153, 2015. [Journal: Article] [CI: 15] [IF: 7]
DOI: 10.1016/j.stemcr.2015.05.017 SCOPUS: 84937523490.

Negrão R., Duarte D., Costa R., Soares R.,

Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways. BioFactors39(6):608-622, 2013. [Journal: Article] [CI: 15] [IF: 3]
DOI: 10.1002/biof.1122 SCOPUS: 84888135448.

Athanasiou D., Edgar L.T., Jafarnejad M., Nixon K., Duarte D., Hawkins E.D., Jamalian S., Cunnea P., Lo Celso C., Kobayashi S., Fotopoulou C., Moore J.E.,

The passive biomechanics of human pelvic collecting lymphatic vessels. PLoS ONE12(8):, 2017. [Journal: Article] [CI: 2] [IF: 2,8]
DOI: 10.1371/journal.pone.0183222 SCOPUS: 85027868260.