Delfim Duarte

Hematopoiesis and Microenvironments

Group leader

I am physician-scientist and leader of the Hematopoiesis and Microenvironments group. My teams’ goals are to study the cell extrinsic regulation of leukemia and hematopoiesis at the local and systemic levels and to unravel new biological mechanisms in leukemia through in vivo studies. I am also a clinician at the Dept of Hematology and Bone Marrow Transplantation in IPO-Porto and an Invited Assistant Professor at the Faculty of Medicine, University of Porto (FMUP).

I previously performed research in the fields of angiogenesis and inflammation (FMUP). In my PhD studies (Lo Celso's lab, Imperial College London), I reported that T-ALL is niche-agnostic and extremely motile (Hawkins* and Duarte* et al. Nature 2016), investigated acute leukemia cell in vivo migration (Immunology and Cell Biology, 2019) and studied how HSC-supporting niches are disrupted in AML (Duarte et al. Cell Stem Cell. 2018). In 2017, I was part of the EHA-ASH Translational Research Training in Hematology (TRTH) program. More recently, in collaboration with Graça Porto, we showed how iron is redistributed in AML and what are the clinical implications of this redistribution (Lopes M et al. Blood Advances. 2021) and demonstrated that Nrf2-mediated anti-oxidant cellular defense is crucial to prevent the emergence of myelodysplasia and innefective hematopoiesis (Duarte TL et al. Leukemia 2023)

List of Publications: https://tinyurl.com/3rrtjeys

Selected Publications

Duarte T.L., Lopes M., Oliveira M., Santos A.G., Vasco C., Reis J.P., Antunes A.R., Gonçalves A., Chacim S., Oliveira C., Porto B., Teles M.J., Moreira A.C., Silva A.M.N., Schwessinger R., Drakesmith H., Henrique R., Porto G., Duarte D.,

Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice. Leukemia:, 2023. [Journal: Article] [IF: 11,4 (*)]
DOI: 10.1038/s41375-023-02067-9 SCOPUS: 85174512949.

Lopes M., Duarte T.L., Teles M.J., Mosteo L., Chacim S., Aguiar E., Pereira-Reis J., Oliveira M., Silva A.M.N., Goncalves N., Martins G., Kong I.Y., Zethoven M., Vervoort S., Martins S., Quintela M., Hawkins E.D., Trigo F., Guimaraes J.T., Mariz J.M., Porto G., Duarte D.,

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications. Blood Advances5(16):3102-3112, 2021. [Journal: Article] [CI: 6] [IF: 7,6]
DOI: 10.1182/bloodadvances.2021004373 SCOPUS: 85113994709.

Sinha S., Pereira-Reis J., Guerra A., Rivella S., Duarte D.,

The Role of Iron in Benign and Malignant Hematopoiesis. Antioxidants and Redox Signaling35(6):415-432, 2021. [Journal: Review] [CI: 13] [IF: 7,5]
DOI: 10.1089/ars.2020.8155 SCOPUS: 85105672354.

Ombrato L., Nolan E., Passaro D., Kurelac I., Bridgeman V.L., Waclawiczek A., Duarte D., Lo Celso C., Bonnet D., Malanchi I.,

Generation of neighbor-labeling cells to study intercellular interactions in vivo. Nature Protocols16(2):872-892, 2021. [Journal: Article] [CI: 13] [IF: 17]
DOI: 10.1038/s41596-020-00438-5 SCOPUS: 85100956227.

Duarte D., Amarteifio S., Ang H., Kong I.Y., Ruivo N., Pruessner G., Hawkins E.D., Lo Celso C.,

Defining the inαvivo characteristics of acute myeloid leukemia cells behavior by intravital imaging. Immunology and Cell Biology97(2):229-235, 2019. [Journal: Article] [CI: 18] [IF: 3,7]
DOI: 10.1111/imcb.12216 SCOPUS: 85058390194.

Duarte D., Hawkins E.D., Akinduro O., Ang H., De Filippo K., Kong I.Y., Haltalli M., Ruivo N., Straszkowski L., Vervoort S.J., McLean C., Weber T.S., Khorshed R., Pirillo C., Wei A., Ramasamy S.K., Kusumbe A.P., Duffy K., Adams R.H., Purton L.E., Carlin L.M., Lo Celso C.,

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML. Cell Stem Cell22(1):64-77.e6, 2018. [Journal: Article] [CI: 203] [IF: 21,5]
DOI: 10.1016/j.stem.2017.11.006 SCOPUS: 85038843065.

Duarte D., Hawkins E.D., Lo Celso C.,

The interplay of leukemia cells and the bone marrow microenvironment. Blood131(14):1507-1511, 2018. [Journal: Review] [CI: 73] [IF: 16,6]
DOI: 10.1182/blood-2017-12-784132 SCOPUS: 85047608213.

Akinduro O., Weber T.S., Ang H., Haltalli M.L.R., Ruivo N., Duarte D., Rashidi N.M., Hawkins E.D., Duffy K.R., Lo Celso C.,

Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space. Nature Communications9(1):, 2018. [Journal: Article] [CI: 56] [IF: 11,9]
DOI: 10.1038/s41467-017-02376-5 SCOPUS: 85041639415.

Hawkins E.D., Duarte D., Akinduro O., Khorshed R.A., Passaro D., Nowicka M., Straszkowski L., Scott M.K., Rothery S., Ruivo N., Foster K., Waibel M., Johnstone R.W., Harrison S.J., Westerman D.A., Quach H., Gribben J., Robinson M.D., Purton L.E., Bonnet D., Lo Celso C.,

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments. Nature538(7626):518-522, 2016. [Journal: Article] [CI: 139] [IF: 40,1]
DOI: 10.1038/nature19801 SCOPUS: 84994005268.

Duarte D., Taveira-Gomes T., Sokhatska O., Palmares C., Costa R., Negrão R., Guimarães J.T., Delgado L., Soares R., Moreira A.,

Increased circulating platelet microparticles as a potential biomarker in asthma. Allergy: European Journal of Allergy and Clinical Immunology68(8):1073-1075, 2013. [Journal: Article] [CI: 43] [IF: 6]
DOI: 10.1111/all.12190 SCOPUS: 84883181922.