I am physician-scientist interested in understanding ecological interactions between malignant and non-malignant cells and their surrounding microenvironments. I have a particular interest in bone marrow (BM) niches, leukemia, hematopoiesis, vascular biology and intravital microscopy.
I have previously performed research in the fields of angiogenesis, inflammation and cell microparticles in Raquel Soares' lab (FMUP). In 2014, I moved to Cristina Lo Celso's lab (Imperial College London; GABBA program) where I studied the interaction between acute leukaemic cells and BM niches. As part of my studies, I reported that T-ALL is niche-agnostic and extremely motile (Hawkins* and Duarte* et al. Nature 2016). I have also investigated acute leukemia cell in vivo migration at different disease stages (Immunology and Cell Biology, 2019) and the disruption of HSC-supporting niches in AML (Duarte et al. Cell Stem Cell. 2018; Akinduro et al. Nat Comms. 2018). In 2017, I was part of the European Hematology Association (EHA)-American Society Hematology (ASH) Translational Research Training in Hematology (TRTH) program.
I am currently developing my clinical activity at IPO-Porto and performing translational research ai i3S. My research program is currently funded by EHA, NBF, Fundação Amélia de Mello and SPH.
Selected Publications
DOI: 10.1016/j.stem.2017.11.006 SCOPUS: 85038843065.
Hawkins E.D., Duarte D., Akinduro O., Khorshed R.A., Passaro D., Nowicka M., Straszkowski L., Scott M.K., Rothery S., Ruivo N., Foster K., Waibel M., Johnstone R.W., Harrison S.J., Westerman D.A., Quach H., Gribben J., Robinson M.D., Purton L.E., Bonnet D., Lo Celso C.,
DOI: 10.1038/nature19801 SCOPUS: 84994005268.
Duarte D., Amarteifio S., Ang H., Kong I.Y., Ruivo N., Pruessner G., Hawkins E.D., Lo Celso C.,
DOI: 10.1111/imcb.12216 SCOPUS: 85058390194.
Duarte D., Hawkins E.D., Lo Celso C.,
DOI: 10.1182/blood-2017-12-784132 SCOPUS: 85047608213.
Akinduro O., Weber T.S., Ang H., Haltalli M.L.R., Ruivo N., Duarte D., Rashidi N.M., Hawkins E.D., Duffy K.R., Lo Celso C.,
DOI: 10.1038/s41467-017-02376-5 SCOPUS: 85041639415.
Tjin G., Flores-Figueroa E., Duarte D., Straszkowski L., Scott M., Khorshed R.A., Purton L.E., Lo Celso C.,
DOI: 10.1016/j.bone.2018.04.022 SCOPUS: 85046379604.
Duarte D., Taveira-Gomes T., Sokhatska O., Palmares C., Costa R., Negrão R., Guimarães J.T., Delgado L., Soares R., Moreira A.,
DOI: 10.1111/all.12190 SCOPUS: 84883181922.
Khorshed R.A., Hawkins E.D., Duarte D., Scott M.K., Akinduro O.A., Rashidi N.M., Spitaler M., Lo Celso C.,
DOI: 10.1016/j.stemcr.2015.05.017 SCOPUS: 84937523490.
Negrão R., Duarte D., Costa R., Soares R.,
DOI: 10.1002/biof.1122 SCOPUS: 84888135448.
Athanasiou D., Edgar L.T., Jafarnejad M., Nixon K., Duarte D., Hawkins E.D., Jamalian S., Cunnea P., Lo Celso C., Kobayashi S., Fotopoulou C., Moore J.E.,
DOI: 10.1371/journal.pone.0183222 SCOPUS: 85027868260.