Where Ideas grow
Cristina Martins
Principal Researcher
M Cristina L Martins is an expert in the development of biomaterial coatings designed at the nanoscale using self-assembled monolayers (SAMs) and biomedical polymers. She got her PhD in Engineering Sciences at Faculty of Engineering of the University of Porto (FEUP) in 2003. Her PhD studies were performed at INEB (Instituto de Engenharia Biomédica) and UWEB (University of Washington Engineered Biomaterials, Seattle, Washington, USA). She is Assistant Investigator of INEB since 2005 and Affiliated Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of the University of Porto. Her group is investigating the effect of surface immobilized ligands (proteins/peptides; fatty acids like and glycosylated compounds) in the guiding of specific protein/cell binding to control bacterial adhesion (e.g., for gastric infection or osteomyelitis prevention) and/or thrombus formation. Full CV available here

Selected Publications

Seabra C.L., Nunes C., Gomez-Lazaro M., Correia M., Machado J.C., Gonçalves I.C., Reis C.A., Reis S., Martins M.C.L.,
Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori. International Journal of Pharmaceutics519(1-2):128-137, 2017. [Journal: Article] [CI: 17] [IF: 3,9]
DOI: 10.1016/j.ijpharm.2017.01.014 SCOPUS: 85010199517.

Felgueiras H.P., Wang L.M., Ren K.F., Querido M.M., Jin Q., Barbosa M.A., Ji J., Martins M.C.L.,
Octadecyl Chains Immobilized onto Hyaluronic Acid Coatings by Thiol-ene “Click Chemistry” Increase the Surface Antimicrobial Properties and Prevent Platelet Adhesion and Activation to Polyurethane. ACS Applied Materials and Interfaces9(9):7979-7989, 2017. [Journal: Article] [CI: 24] [IF: 8,1]
DOI: 10.1021/acsami.6b16415 SCOPUS: 85014824553.

Barbosa M., Vale N., Costa F.M.T.A., Martins M.C.L., Gomes P.,
Tethering antimicrobial peptides onto chitosan: Optimization of azide-alkyne “click” reaction conditions. Carbohydrate Polymers165:384-393, 2017. [Journal: Article] [CI: 22] [IF: 5,2]
DOI: 10.1016/j.carbpol.2017.02.050 SCOPUS: 85013929503.

Gonçalves I.C., Magalhães A., Costa A.M.S., Oliveira J.R., Henriques P.C., Gomes P., Reis C.A., Martins M.C.L.,
Bacteria-targeted biomaterials: Glycan-coated microspheres to bind Helicobacter pylori. Acta Biomaterialia33:40-50, 2016. [Journal: Article] [CI: 9] [IF: 6,3]
DOI: 10.1016/j.actbio.2016.01.029 SCOPUS: 84959468144.

Monteiro C., Pinheiro M., Fernandes M., Maia S., Seabra C.L., Ferreira-Da-Silva F., Reis S., Gomes P., Martins M.C.L.,
A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells. Molecular Pharmaceutics12(8):2904-2911, 2015. [Journal: Article] [CI: 14] [IF: 4,3]
DOI: 10.1021/acs.molpharmaceut.5b00113 SCOPUS: 84938303316.

Costa F.M.T.A., Maia S.R., Gomes P.A.C., Martins M.C.L.,
Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption. Biomaterials52(1):531-538, 2015. [Journal: Article] [CI: 42] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2015.02.049 SCOPUS: 84932632783.

Costa F., Maia S., Gomes J., Gomes P., Martins M.C.L.,
Characterization of hLF1-11 immobilization onto chitosan ultrathin films, and its effects on antimicrobial activity. Acta Biomaterialia10(8):3513-3521, 2014. [Journal: Article] [CI: 50] [IF: 6]
DOI: 10.1016/j.actbio.2014.02.028 SCOPUS: 84903724424.

Parreira P., Magalhães A., Reis C.A., Borén T., Leckband D., Martins M.C.L.,
Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori. Acta Biomaterialia9(11):8885-8893, 2013. [Journal: Article] [CI: 14] [IF: 5,7]
DOI: 10.1016/j.actbio.2013.06.042 SCOPUS: 84885052038.

Nogueira F., Gonçalves I.C., Martins M.C.L.,
Effect of gastric environment on Helicobacter pylori adhesion to a mucoadhesive polymer. Acta Biomaterialia9(2):5208-5215, 2013. [Journal: Article] [CI: 31] [IF: 5,7]
DOI: 10.1016/j.actbio.2012.09.011 SCOPUS: 84872069015.

Fernandes M., Gonçalves I.C., Nardecchia S., Amaral I.F., Barbosa M.A., Martins M.C.L.,
Modulation of stability and mucoadhesive properties of chitosan microspheres for therapeutic gastric application. International Journal of Pharmaceutics454(1):116-124, 2013. [Journal: Article] [CI: 39] [IF: 3,8]
DOI: 10.1016/j.ijpharm.2013.06.068 SCOPUS: 84884163785.

Costa F., Carvalho I.F., Montelaro R.C., Gomes P., Martins M.C.L.,
Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces. Acta Biomaterialia7(4):1431-1440, 2011. [Journal: Review] [CI: 370] [IF: 4,9]
DOI: 10.1016/j.actbio.2010.11.005 SCOPUS: 79952187401.

Rodrigues S.N., Gonçalves I.C., Martins M.C.L., Barbosa M.A., Ratner B.D.,
Fibrinogen adsorption, platelet adhesion and activation on mixed hydroxyl-/methyl-terminated self-assembled monolayers. Biomaterials27(31):5357-5367, 2006. [Journal: Article] [CI: 168] [IF: 5,2]
DOI: 10.1016/j.biomaterials.2006.06.010 SCOPUS: 33746216936.