Cristina Martins
BioEngineered Surfaces
Group leader
M Cristina L Martins is an expert in the development of biomaterial coatings designed at the nanoscale using self-assembled monolayers (SAMs) and biomedical polymers. She got her PhD in Engineering Sciences at Faculty of Engineering of the University of Porto (FEUP) in 2003. Her PhD studies were performed at INEB (Instituto de Engenharia Biomédica) and UWEB (University of Washington Engineered Biomaterials, Seattle, Washington, USA). She is Principal Investigator of INEB/i3S and Invited Assistant Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of the University of Porto. Her group is investigating the effect of surface immobilized ligands (proteins/peptides; fatty acids like and glycosylated compounds) in the guiding of specific protein/cell binding to control bacterial adhesion (e.g., for gastric infection or osteomyelitis prevention) and/or thrombus formation. Full CV available here
Selected Publications
Mousavifar L., Parreira P., Taponard A., Graça V.C.D., Martins M.C.L., Roy R.,
Alves P.M., Pereira R.F., Costa B., Tassi N., Teixeira C., Leiro V., Monteiro C., Gomes P., Costa F., Martins M.C.L.,
Chitas R., Nunes C., Reis S., Parreira P., Martins M.C.L.,
Ramôa A.M., Campos F., Moreira L., Teixeira C., Leiro V., Gomes P., das Neves J., Martins M.C.L., Monteiro C.,
Fonseca D.R., Moura A., Leiro V., Silva-Carvalho R., Estevinho B.N., Seabra C.L., Henriques P.C., Lucena M., Teixeira C., Gomes P., Parreira P., Martins M.C.L.,
Huang Y., Li D., Wang D., Chen X., Ferreira L., Martins M.C.L., Wang Y., Jin Q., Wang D., Tang B.Z., Ji J.,
Pinho A.S., Seabra C.L., Nunes C., Reis S., L. Martins M.C., Parreira P.,
Matinha-Cardoso J., Mota R., Gomes L.C., Gomes M., Mergulhão F.J., Tamagnini P., Martins M.C.L., Costa F.,
Monteiro C., Fernandes H., Oliveira D., Vale N., Barbosa M., Gomes P., Martins M.C.L.,
Parreira P., Monteiro C., Graça V., Gomes J., Maia S., Gomes P., Gonçalves I.C., Martins M.C.L.,
Barbosa M., Costa F., Monteiro C., Duarte F., Martins M.C.L., Gomes P.,
Maitz M.F., Martins M.C.L., Grabow N., Matschegewski C., Huang N., Chaikof E.L., Barbosa M.A., Werner C., Sperling C.,
Monteiro C., Costa F., Pirttilä A.M., Tejesvi M.V., Martins M.C.L.,
Querido M.M., Felgueiras H.P., Rai A., Costa F., Monteiro C., Borges I., Oliveira D., Ferreira L., Martins M.C.L.,
Felgueiras H.P., Wang L.M., Ren K.F., Querido M.M., Jin Q., Barbosa M.A., Ji J., Martins M.C.L.,
Seabra C.L., Nunes C., Gomez-Lazaro M., Correia M., Machado J.C., Gonçalves I.C., Reis C.A., Reis S., Martins M.C.L.,
Gonçalves I.C., Magalhães A., Costa A.M.S., Oliveira J.R., Henriques P.C., Gomes P., Reis C.A., Martins M.C.L.,
Costa F.M.T.A., Maia S.R., Gomes P.A.C., Martins M.C.L.,
Monteiro C., Pinheiro M., Fernandes M., Maia S., Seabra C.L., Ferreira-Da-Silva F., Reis S., Gomes P., Martins M.C.L.,
Costa F., Carvalho I.F., Montelaro R.C., Gomes P., Martins M.C.L.,
Rodrigues S.N., Gonçalves I.C., Martins M.C.L., Barbosa M.A., Ratner B.D.,
Validation of Selective Capture of Fimbriated Uropathogenic Escherichia coli by a Label-free Engineering Detection System Using Mannosylated Surfaces. ACS Applied Bio Materials5(12):5877-5886, 2022. [Journal: Article] [CI: 2] [IF: 4,7]
DOI: 10.1021/acsabm.2c00838 SCOPUS: 85143063099.
DOI: 10.1021/acsabm.2c00838 SCOPUS: 85143063099.
Alves P.M., Pereira R.F., Costa B., Tassi N., Teixeira C., Leiro V., Monteiro C., Gomes P., Costa F., Martins M.C.L.,
Thiol-Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials. ACS Applied Polymer Materials4(7):5012-5026, 2022. [Journal: Article] [CI: 5] [IF: 5]
DOI: 10.1021/acsapm.2c00563 SCOPUS: 85135691768.
DOI: 10.1021/acsapm.2c00563 SCOPUS: 85135691768.
Chitas R., Nunes C., Reis S., Parreira P., Martins M.C.L.,
How Charge, Size and Protein Corona Modulate the Specific Activity of Nanostructured Lipid Carriers (NLC) against Helicobacter pylori. Pharmaceutics14(12):, 2022. [Journal: Article] [CI: 1] [IF: 5,4]
DOI: 10.3390/pharmaceutics14122745 SCOPUS: 85144862441.
DOI: 10.3390/pharmaceutics14122745 SCOPUS: 85144862441.
Ramôa A.M., Campos F., Moreira L., Teixeira C., Leiro V., Gomes P., das Neves J., Martins M.C.L., Monteiro C.,
Antimicrobial peptide-grafted PLGA-PEG nanoparticles to fight bacterial wound infections. Biomaterials Science11(2):499-508, 2022. [Journal: Article] [CI: 2] [IF: 6,6]
DOI: 10.1039/d2bm01127a SCOPUS: 85144032387.
DOI: 10.1039/d2bm01127a SCOPUS: 85144032387.
Fonseca D.R., Moura A., Leiro V., Silva-Carvalho R., Estevinho B.N., Seabra C.L., Henriques P.C., Lucena M., Teixeira C., Gomes P., Parreira P., Martins M.C.L.,
Grafting MSI-78A onto chitosan microspheres enhances its antimicrobial activity. Acta Biomaterialia137:186-198, 2022. [Journal: Article] [CI: 8] [IF: 9,7]
DOI: 10.1016/j.actbio.2021.09.063 SCOPUS: 85118721492.
DOI: 10.1016/j.actbio.2021.09.063 SCOPUS: 85118721492.
Huang Y., Li D., Wang D., Chen X., Ferreira L., Martins M.C.L., Wang Y., Jin Q., Wang D., Tang B.Z., Ji J.,
A NIR-II emissive polymer AIEgen for imaging-guided photothermal elimination of bacterial infection. Biomaterials286:, 2022. [Journal: Article] [CI: 28] [IF: 14]
DOI: 10.1016/j.biomaterials.2022.121579 SCOPUS: 85130475890.
DOI: 10.1016/j.biomaterials.2022.121579 SCOPUS: 85130475890.
Pinho A.S., Seabra C.L., Nunes C., Reis S., L. Martins M.C., Parreira P.,
Helicobacter pylori biofilms are disrupted by nanostructured lipid carriers: A path to eradication?. Journal of Controlled Release348:489-498, 2022. [Journal: Article] [CI: 5] [IF: 10,8]
DOI: 10.1016/j.jconrel.2022.05.050 SCOPUS: 85132423536.
DOI: 10.1016/j.jconrel.2022.05.050 SCOPUS: 85132423536.
Matinha-Cardoso J., Mota R., Gomes L.C., Gomes M., Mergulhão F.J., Tamagnini P., Martins M.C.L., Costa F.,
Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating. Journal of Materials Chemistry B9(17):3705-3715, 2021. [Journal: Article] [CI: 7] [IF: 7,6]
DOI: 10.1039/d1tb00278c SCOPUS: 85105524958.
DOI: 10.1039/d1tb00278c SCOPUS: 85105524958.
Monteiro C., Fernandes H., Oliveira D., Vale N., Barbosa M., Gomes P., Martins M.C.L.,
AMP-chitosan coating with bactericidal activity in the presence of human plasma proteins. Molecules25(13):, 2020. [Journal: Article] [CI: 13] [IF: 4,4]
DOI: 10.3390/molecules25133046 SCOPUS: 85087666295.
DOI: 10.3390/molecules25133046 SCOPUS: 85087666295.
Parreira P., Monteiro C., Graça V., Gomes J., Maia S., Gomes P., Gonçalves I.C., Martins M.C.L.,
Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management. Scientific Reports9(1):, 2019. [Journal: Article] [CI: 16] [IF: 4]
DOI: 10.1038/s41598-019-53918-4 SCOPUS: 85075982293.
DOI: 10.1038/s41598-019-53918-4 SCOPUS: 85075982293.
Barbosa M., Costa F., Monteiro C., Duarte F., Martins M.C.L., Gomes P.,
Antimicrobial coatings prepared from Dhvar-5-click-grafted chitosan powders. Acta Biomaterialia84:242-256, 2019. [Journal: Article] [CI: 41] [IF: 7,2]
DOI: 10.1016/j.actbio.2018.12.001 SCOPUS: 85058393291.
DOI: 10.1016/j.actbio.2018.12.001 SCOPUS: 85058393291.
Maitz M.F., Martins M.C.L., Grabow N., Matschegewski C., Huang N., Chaikof E.L., Barbosa M.A., Werner C., Sperling C.,
The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions. Acta Biomaterialia94:33-43, 2019. [Journal: Review] [CI: 75] [IF: 7,2]
DOI: 10.1016/j.actbio.2019.06.019 SCOPUS: 85067887675.
DOI: 10.1016/j.actbio.2019.06.019 SCOPUS: 85067887675.
Monteiro C., Costa F., Pirttilä A.M., Tejesvi M.V., Martins M.C.L.,
Prevention of urinary catheter-associated infections by coating antimicrobial peptides from crowberry endophytes. Scientific Reports9(1):, 2019. [Journal: Article] [CI: 44] [IF: 4]
DOI: 10.1038/s41598-019-47108-5 SCOPUS: 85069748855.
DOI: 10.1038/s41598-019-47108-5 SCOPUS: 85069748855.
Querido M.M., Felgueiras H.P., Rai A., Costa F., Monteiro C., Borges I., Oliveira D., Ferreira L., Martins M.C.L.,
Cecropin–Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation. Advanced Materials Interfaces5(24):, 2018. [Journal: Article] [CI: 16] [IF: 4,7]
DOI: 10.1002/admi.201801390 SCOPUS: 85055708783.
DOI: 10.1002/admi.201801390 SCOPUS: 85055708783.
Felgueiras H.P., Wang L.M., Ren K.F., Querido M.M., Jin Q., Barbosa M.A., Ji J., Martins M.C.L.,
Octadecyl Chains Immobilized onto Hyaluronic Acid Coatings by Thiol-ene “Click Chemistry” Increase the Surface Antimicrobial Properties and Prevent Platelet Adhesion and Activation to Polyurethane. ACS Applied Materials and Interfaces9(9):7979-7989, 2017. [Journal: Article] [CI: 45] [IF: 8,1]
DOI: 10.1021/acsami.6b16415 SCOPUS: 85014824553.
DOI: 10.1021/acsami.6b16415 SCOPUS: 85014824553.
Seabra C.L., Nunes C., Gomez-Lazaro M., Correia M., Machado J.C., Gonçalves I.C., Reis C.A., Reis S., Martins M.C.L.,
Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori. International Journal of Pharmaceutics519(1-2):128-137, 2017. [Journal: Article] [CI: 40] [IF: 3,9]
DOI: 10.1016/j.ijpharm.2017.01.014 SCOPUS: 85010199517.
DOI: 10.1016/j.ijpharm.2017.01.014 SCOPUS: 85010199517.
Gonçalves I.C., Magalhães A., Costa A.M.S., Oliveira J.R., Henriques P.C., Gomes P., Reis C.A., Martins M.C.L.,
Bacteria-targeted biomaterials: Glycan-coated microspheres to bind Helicobacter pylori. Acta Biomaterialia33:40-50, 2016. [Journal: Article] [CI: 13] [IF: 6,3]
DOI: 10.1016/j.actbio.2016.01.029 SCOPUS: 84959468144.
DOI: 10.1016/j.actbio.2016.01.029 SCOPUS: 84959468144.
Costa F.M.T.A., Maia S.R., Gomes P.A.C., Martins M.C.L.,
Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption. Biomaterials52(1):531-538, 2015. [Journal: Article] [CI: 72] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2015.02.049 SCOPUS: 84932632783.
DOI: 10.1016/j.biomaterials.2015.02.049 SCOPUS: 84932632783.
Monteiro C., Pinheiro M., Fernandes M., Maia S., Seabra C.L., Ferreira-Da-Silva F., Reis S., Gomes P., Martins M.C.L.,
A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells. Molecular Pharmaceutics12(8):2904-2911, 2015. [Journal: Article] [CI: 21] [IF: 4,3]
DOI: 10.1021/acs.molpharmaceut.5b00113 SCOPUS: 84938303316.
DOI: 10.1021/acs.molpharmaceut.5b00113 SCOPUS: 84938303316.
Costa F., Carvalho I.F., Montelaro R.C., Gomes P., Martins M.C.L.,
Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces. Acta Biomaterialia7(4):1431-1440, 2011. [Journal: Review] [CI: 485] [IF: 4,9]
DOI: 10.1016/j.actbio.2010.11.005 SCOPUS: 79952187401.
DOI: 10.1016/j.actbio.2010.11.005 SCOPUS: 79952187401.
Rodrigues S.N., Gonçalves I.C., Martins M.C.L., Barbosa M.A., Ratner B.D.,
Fibrinogen adsorption, platelet adhesion and activation on mixed hydroxyl-/methyl-terminated self-assembled monolayers. Biomaterials27(31):5357-5367, 2006. [Journal: Article] [CI: 204] [IF: 5,2]
DOI: 10.1016/j.biomaterials.2006.06.010 SCOPUS: 33746216936.
DOI: 10.1016/j.biomaterials.2006.06.010 SCOPUS: 33746216936.