creating a
healthier future
Cristina Martins
Group leader

M Cristina L Martins is an expert in the development of biomaterial coatings designed at the nanoscale using self-assembled monolayers (SAMs) and biomedical polymers. She got her PhD in Engineering Sciences at Faculty of Engineering of the University of Porto (FEUP) in 2003. Her PhD studies were performed at INEB (Instituto de Engenharia Biomédica) and UWEB (University of Washington Engineered Biomaterials, Seattle, Washington, USA). She is Principal Investigator of INEB/i3S and Invited Assistant Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of the University of Porto. Her group is investigating the effect of surface immobilized ligands (proteins/peptides; fatty acids like and glycosylated compounds) in the guiding of specific protein/cell binding to control bacterial adhesion (e.g., for gastric infection or osteomyelitis prevention) and/or thrombus formation. Full CV available here

Selected Publications

Fonseca D.R., Alves P.M., Neto E., Custódio B., Guimarães S., Moura D., Annis F., Martins M., Gomes A., Teixeira C., Gomes P., Pereira R.F., Freitas P., Parreira P., Martins M.C.L.,
One-Pot Microfluidics to Engineer Chitosan Nanoparticles Conjugated with Antimicrobial Peptides Using “Photoclick” Chemistry: Validation Using the Gastric Bacterium Helicobacter pylori. ACS Applied Materials and Interfaces16(12):14533-14547, 2024. [Journal: Article] [CI: 1] [IF: 9,5 (*)]
DOI: 10.1021/acsami.3c18772 SCOPUS: 85187652527.


Redondo-Gómez C., Parreira P., Martins M.C.L., Azevedo H.S.,
Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa. Chemical Society Reviews53(8):3714-3773, 2024. [Journal: Review] [IF: 46,2 (*)]
DOI: 10.1039/d3cs00921a SCOPUS: 85187679238.


Seabra C.L., Pinho A.S., Nunes C., Amorim I., Pedro N., Henriques P., Monteiro C., Gomes J., Machado C., Gartner F., Pereira L., Reis S., Reis C.A., Touati E., Gonçalves I.C., Parreira P., Martins M.C.L.,
Paving the way for a non-antibiotic and microbiota friendly therapy for Helicobacter pylori: Inαvitro and inαvivo performance of lipid nanoparticles. Helicobacter29(1):, 2024. [Journal: Article] [IF: 4,4 (*)]
DOI: 10.1111/hel.13050 SCOPUS: 85182844513.


Alves P.M., Fonseca D.R., Bidarra S.J., Gomes A., Gomes P., Barrias C.C., Martins M.C.L.,
Norbornene-chitosan nanoparticles with and without a conjugated VEGF-peptide analog to promote vascularization. Materials Today Chemistry36:, 2024. [Journal: Article] [IF: 7,3 (*)]
DOI: 10.1016/j.mtchem.2024.101942 SCOPUS: 85184149781.


Fonseca D.R., Chitas R., Parreira P., Martins M.C.L.,
How to manage Helicobacter pylori infection beyond antibiotics: The bioengineering quest. Applied Materials Today37:, 2024. [Journal: Review] [CI: 2] [IF: 8,3 (*)]
DOI: 10.1016/j.apmt.2024.102123 SCOPUS: 85185511905.


Alves P.M., Barrias C.C., Gomes P., Martins M.C.L.,
How can biomaterial-conjugated antimicrobial peptides fight bacteria and be protected from degradation?. Acta Biomaterialia:, 2024. [Journal: Review] [IF: 9,7 (*)]
DOI: 10.1016/j.actbio.2024.04.043 SCOPUS: 85192685915.


Fonseca D.R., Moura A., Leiro V., Silva-Carvalho R., Estevinho B.N., Seabra C.L., Henriques P.C., Lucena M., Teixeira C., Gomes P., Parreira P., Martins M.C.L.,
Grafting MSI-78A onto chitosan microspheres enhances its antimicrobial activity. Acta Biomaterialia137:186-198, 2022. [Journal: Article] [CI: 8] [IF: 9,7]
DOI: 10.1016/j.actbio.2021.09.063 SCOPUS: 85118721492.


Pinho A.S., Seabra C.L., Nunes C., Reis S., L. Martins M.C., Parreira P.,
Helicobacter pylori biofilms are disrupted by nanostructured lipid carriers: A path to eradication?. Journal of Controlled Release348:489-498, 2022. [Journal: Article] [CI: 5] [IF: 10,8]
DOI: 10.1016/j.jconrel.2022.05.050 SCOPUS: 85132423536.


Alves P.M., Pereira R.F., Costa B., Tassi N., Teixeira C., Leiro V., Monteiro C., Gomes P., Costa F., Martins M.C.L.,
Thiol-Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials. ACS Applied Polymer Materials4(7):5012-5026, 2022. [Journal: Article] [CI: 5] [IF: 5]
DOI: 10.1021/acsapm.2c00563 SCOPUS: 85135691768.


Chitas R., Nunes C., Reis S., Parreira P., Martins M.C.L.,
How Charge, Size and Protein Corona Modulate the Specific Activity of Nanostructured Lipid Carriers (NLC) against Helicobacter pylori. Pharmaceutics14(12):, 2022. [Journal: Article] [CI: 1] [IF: 5,4]
DOI: 10.3390/pharmaceutics14122745 SCOPUS: 85144862441.


Ramôa A.M., Campos F., Moreira L., Teixeira C., Leiro V., Gomes P., das Neves J., Martins M.C.L., Monteiro C.,
Antimicrobial peptide-grafted PLGA-PEG nanoparticles to fight bacterial wound infections. Biomaterials Science11(2):499-508, 2022. [Journal: Article] [CI: 2] [IF: 6,6]
DOI: 10.1039/d2bm01127a SCOPUS: 85144032387.


Matinha-Cardoso J., Mota R., Gomes L.C., Gomes M., Mergulhão F.J., Tamagnini P., Martins M.C.L., Costa F.,
Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating. Journal of Materials Chemistry B9(17):3705-3715, 2021. [Journal: Article] [CI: 7] [IF: 7,6]
DOI: 10.1039/d1tb00278c SCOPUS: 85105524958.


Parreira P., Monteiro C., Graça V., Gomes J., Maia S., Gomes P., Gonçalves I.C., Martins M.C.L.,
Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management. Scientific Reports9(1):, 2019. [Journal: Article] [CI: 16] [IF: 4]
DOI: 10.1038/s41598-019-53918-4 SCOPUS: 85075982293.


Maitz M.F., Martins M.C.L., Grabow N., Matschegewski C., Huang N., Chaikof E.L., Barbosa M.A., Werner C., Sperling C.,
The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions. Acta Biomaterialia94:33-43, 2019. [Journal: Review] [CI: 75] [IF: 7,2]
DOI: 10.1016/j.actbio.2019.06.019 SCOPUS: 85067887675.