Where Ideas grow
João Morais Cabral
Principal Researcher
Undergraduate degree in Biochemistry from University of Porto, followed by a research assistant position at the University´s Chemistry department. From 1988 to 1993 I did my PhD at the University of Edinburgh in Scotland after which I went for a postdoc with Robert Liddington, first at the Dana-Farber Cancer Institute/Harvard University in Boston and then at the University of Leicester in the UK. From 1997 to 2000 I did a second postdoc with Roderick MacKinnon at Rockefeller University in New York. I then joined the faculty of the MBB department at Yale University as Assistant professor. In 2007 I was promoted to Associate professor. In 2008 I moved to the IBMC as a Principal Investigator.

Selected Publications

Teixeira-Duarte C.M., Fonseca F., Morais-Cabral J.H.,
Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site. eLife8:, 2019. [Journal: Article] [CI: 2] [IF: 7,1]
DOI: 10.7554/eLife.50661 SCOPUS: 85077594921.


Rocha R., Teixeira-Duarte C.M., Jorge J.M.P., Morais-Cabral J.H.,
Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis. Journal of Structural Biology205(3):34-43, 2019. [Journal: Article] [CI: 10] [IF: 3,1]
DOI: 10.1016/j.jsb.2019.02.002 SCOPUS: 85061548530.


Castro-Rodrigues A.F., Zhao Y., Fonseca F., Gabant G., Cadene M., Robertson G.A., Morais-Cabral J.H.,
The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase. Journal of Molecular Biology430(24):5029-5049, 2018. [Journal: Article] [CI: 1] [IF: 5,1]
DOI: 10.1016/j.jmb.2018.10.015 SCOPUS: 85056216681.


Szollosi A., Vieira-Pires R.S., Teixeira-Duarte C.M., Rocha R., Morais-Cabral J.H.,
Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter. PLoS Biology14(1):, 2016. [Journal: Article] [CI: 11] [IF: 9,8]
DOI: 10.1371/journal.pbio.1002356 SCOPUS: 84961353773.


Marques-Carvalho M.J., Oppermann J., Muñoz E., Fernandes A.S., Gabant G., Cadene M., Heinemann S.H., Schönherr R., Morais-Cabral J.H.,
Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel. Structure24(10):1742-1754, 2016. [Journal: Article] [CI: 7] [IF: 4,9]
DOI: 10.1016/j.str.2016.07.020 SCOPUS: 84989908805.


Harley C.A., Starek G., Jones D.K., Fernandes A.S., Robertson G.A., Morais-Cabral J.H.,
Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain. Proceedings of the National Academy of Sciences of the United States of America113(35):9916-9921, 2016. [Journal: Article] [CI: 8] [IF: 9,7]
DOI: 10.1073/pnas.1601116113 SCOPUS: 84984876913.


Morais-Cabral J.H., Robertson G.A.,
The enigmatic cytoplasmic regions of KCNH channels. Journal of Molecular Biology427(1):67-76, 2015. [Journal: Review] [CI: 27] [IF: 4,5]
DOI: 10.1016/j.jmb.2014.08.008 SCOPUS: 84919618793.


Pessoa J., Fonseca F., Furini S., Morais-Cabral J.H.,
Determinants of ligand selectivity in a cyclic nucleotide-regulated potassium channel. Journal of General Physiology144(1):41-54, 2014. [Journal: Article] [CI: 4] [IF: 4,8]
DOI: 10.1085/jgp.201311145 SCOPUS: 84903790332.


Vieira-Pires R.S., Szollosi A., Morais-Cabral J.H.,
The structure of the KtrAB potassium transporter. Nature496(7445):323-328, 2013. [Journal: Article] [CI: 68] [IF: 42,4]
DOI: 10.1038/nature12055 SCOPUS: 84876273276.


Marques-Carvalho M.J., Sahoo N., Muskett F.W., Vieira-Pires R.S., Gabant G., Cadene M., Schönherr R., Morais-Cabral J.H.,
Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel. Journal of Molecular Biology423(1):34-46, 2012. [Journal: Article] [CI: 43] [IF: 3,9]
DOI: 10.1016/j.jmb.2012.06.025 SCOPUS: 84866343022.