Pedro J. B. Pereira
Macromolecular Structure
Group leader
Graduated in Biochemistry from the University of Porto in 1993. PhD student of Programa Gulbenkian de Doutoramento em Biologia e Medicina from 1993 to 1999. PhD fellow at the Max-Planck-Institut fuer Biochemie (Martinsried, Germany) from 1994 to 1999 (Supervisor: Prof. Dr. Dr. hc mult. Robert Huber). PhD in Biomedical Sciences (Biochemistry) from the University of Porto in 1999. FEBS Long-Term (1999-2000) and FCT (2000-2001) post-doctoral fellow at Institut de Biologia Molecular de Barcelona (IBMB-CSIC, Barcelona, Spain). Investigador Auxiliar (2002-2009) and Investigador Principal (2009-2022) at IBMC (Porto, Portugal). Investigador Principal (since 2023) at i3S (Porto, Portugal).
Selected Publications
José Barbosa Pereira P., Bergner A., Macedo-Ribeiro S., Huber R., Matschiner G., Fritz H., Sommerhoff C., Bode W.
Human β-tryptase is a ring-like tetramer with active sites facing a central pore. Nature392(6673):306-311, 1998. [Journal: Article] [CI: 292] [IF: 28,8]
DOI: 10.1038/32703 SCOPUS: 2642600031
Pereira P.J.B., Lozanov V., Patthy A., Huber R., Bode W., Pongor S., Strobl S.
Specific inhibition of insect α-amylases: Yellow meal worm α-amylase in complex with the Amaranth α-amylase inhibitor at 2.0 Å resolution. Structure7(9):1079-1088, 1999. [Journal: Article] [CI: 87] [IF: 7,3]
DOI: 10.1016/S0969-2126(99)80175-0 SCOPUS: 0006750734
Pereira P., Macedo-Ribeiro S., Párraga A., Pérez-Luque R., Cunningham O., Darcy K., Mantle T., Coll M.
Structure of human biliverdin IXβ reductase, an early fetal bilirubin IXβ producing enzyme. Nature Structural Biology8(3):215-220, 2001. [Journal: Article] [CI: 104] [IF: 11,7]
DOI: 10.1038/84948 SCOPUS: 0035119623
Barbosa Pereira P.J., Segura-Martín S., Oliva B., Ferrer-Orta C., Avilés F.X., Coll M., Gomis-Rüth F.X., Vendrell J.
Human procarboxypeptidase B: Three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). Journal of Molecular Biology321(3):537-547, 2002. [Journal: Article] [CI: 64] [IF: 5,4]
DOI: 10.1016/S0022-2836(02)00648-4 SCOPUS: 0036384505
Rocha R., Pereira P., Santos M., Macedo-Ribeiro S.
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen. Proceedings of the National Academy of Sciences of the United States of America108(34):14091-14096, 2011. [Journal: Article] [CI: 40] [IF: 9,7]
DOI: 10.1073/pnas.1102835108 SCOPUS: 80052182956
Thompson R.E., Liu X., Alonso-García N., Pereira P.J.B., Jolliffe K.A., Payne R.J.
Trifluoroethanethiol: An additive for efficient one-pot peptide ligation - Desulfurization chemistry. Journal of the American Chemical Society136(23):8161-8164, 2014. [Journal: Article] [CI: 116] [IF: 12,1]
DOI: 10.1021/ja502806r SCOPUS: 84902270939
Meyer P.A., Socias S., Key J., Ransey E., Tjon E.C., Buschiazzo A., Lei M., Botka C., Withrow J., Neau D., Rajashankar K., Anderson K.S., Baxter R.H., Blacklow S.C., Boggon T.J., Bonvin A.M.J.J., Borek D., Brett T.J., Caflisch A., Chang C.I., Chazin W.J., Corbett K.D., Cosgrove M.S., Crosson S., Dhe-Paganon S., Di Cera E., Drennan C.L., Eck M.J., Eichman B.F., Fan Q.R., Ferré-D'Amaré A.R., Fromme J.C., Garcia K.C., Gaudet R., Gong P., Harrison S.C., Heldwein E.E., Jia Z., Keenan R.J., Kruse A.C., Kvansakul M., McLellan J.S., Modis Y., Nam Y., Otwinowski Z., Pai E.F., Pereira P.J.B., Petosa C., Raman C.S., Rapoport T.A., Roll-Mecak A., Rosen M.K., Rudenko G., Schlessinger J., Schwartz T.U., Shamoo Y., Sondermann H., Tao Y.J., Tolia N.H., Tsodikov O.V., Westover K.D., Wu H., Foster I., Fraser J.S., Maia F.R.N.C., Gonen T., Kirchhausen T., Diederichs K., Crosas M., Sliz P.
Data publication with the structural biology data grid supports live analysis. Nature Communications7:, 2016. [Journal: Article] [CI: 104] [IF: 12,1]
DOI: 10.1038/ncomms10882 SCOPUS: 84960381776
Mitchell N.J., Sayers J., Kulkarni S.S., Clayton D., Goldys A.M., Ripoll-Rozada J., Barbosa Pereira P.J., Chan B., Radom L., Payne R.J.
Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry. Chem2(5):703-715, 2017. [Journal: Article] [CI: 56] [IF: 14,1]
DOI: 10.1016/j.chempr.2017.04.003 SCOPUS: 85019057964
Watson E.E., Liu X., Thompson R.E., Ripoll-Rozada J., Wu M., Alwis I., Gori A., Loh C.T., Parker B.L., Otting G., Jackson S., Pereira P.J.B., Payne R.J.
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics. ACS Central Science4(4):468-476, 2018. [Journal: Article] [CI: 32] [IF: 12,8]
DOI: 10.1021/acscentsci.7b00612 SCOPUS: 85045964682
Watson E.E., Ripoll-Rozada J., Lee A.C., Wu M.C.L., Franck C., Pasch T., Premdjee B., Sayers J., Pinto M.F., Martins P.M., Jackson S.P., Pereira P.J.B., Payne R.J.
Rapid assembly and profiling of an anticoagulant sulfoprotein library. Proceedings of the National Academy of Sciences of the United States of America116(28):13873-13878, 2019. [Journal: Article] [CI: 24] [IF: 9,4]
DOI: 10.1073/pnas.1905177116 SCOPUS: 85066962891
Human β-tryptase is a ring-like tetramer with active sites facing a central pore. Nature392(6673):306-311, 1998. [Journal: Article] [CI: 292] [IF: 28,8]
DOI: 10.1038/32703 SCOPUS: 2642600031
Pereira P.J.B., Lozanov V., Patthy A., Huber R., Bode W., Pongor S., Strobl S.
Specific inhibition of insect α-amylases: Yellow meal worm α-amylase in complex with the Amaranth α-amylase inhibitor at 2.0 Å resolution. Structure7(9):1079-1088, 1999. [Journal: Article] [CI: 87] [IF: 7,3]
DOI: 10.1016/S0969-2126(99)80175-0 SCOPUS: 0006750734
Pereira P., Macedo-Ribeiro S., Párraga A., Pérez-Luque R., Cunningham O., Darcy K., Mantle T., Coll M.
Structure of human biliverdin IXβ reductase, an early fetal bilirubin IXβ producing enzyme. Nature Structural Biology8(3):215-220, 2001. [Journal: Article] [CI: 104] [IF: 11,7]
DOI: 10.1038/84948 SCOPUS: 0035119623
Barbosa Pereira P.J., Segura-Martín S., Oliva B., Ferrer-Orta C., Avilés F.X., Coll M., Gomis-Rüth F.X., Vendrell J.
Human procarboxypeptidase B: Three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). Journal of Molecular Biology321(3):537-547, 2002. [Journal: Article] [CI: 64] [IF: 5,4]
DOI: 10.1016/S0022-2836(02)00648-4 SCOPUS: 0036384505
Rocha R., Pereira P., Santos M., Macedo-Ribeiro S.
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen. Proceedings of the National Academy of Sciences of the United States of America108(34):14091-14096, 2011. [Journal: Article] [CI: 40] [IF: 9,7]
DOI: 10.1073/pnas.1102835108 SCOPUS: 80052182956
Thompson R.E., Liu X., Alonso-García N., Pereira P.J.B., Jolliffe K.A., Payne R.J.
Trifluoroethanethiol: An additive for efficient one-pot peptide ligation - Desulfurization chemistry. Journal of the American Chemical Society136(23):8161-8164, 2014. [Journal: Article] [CI: 116] [IF: 12,1]
DOI: 10.1021/ja502806r SCOPUS: 84902270939
Meyer P.A., Socias S., Key J., Ransey E., Tjon E.C., Buschiazzo A., Lei M., Botka C., Withrow J., Neau D., Rajashankar K., Anderson K.S., Baxter R.H., Blacklow S.C., Boggon T.J., Bonvin A.M.J.J., Borek D., Brett T.J., Caflisch A., Chang C.I., Chazin W.J., Corbett K.D., Cosgrove M.S., Crosson S., Dhe-Paganon S., Di Cera E., Drennan C.L., Eck M.J., Eichman B.F., Fan Q.R., Ferré-D'Amaré A.R., Fromme J.C., Garcia K.C., Gaudet R., Gong P., Harrison S.C., Heldwein E.E., Jia Z., Keenan R.J., Kruse A.C., Kvansakul M., McLellan J.S., Modis Y., Nam Y., Otwinowski Z., Pai E.F., Pereira P.J.B., Petosa C., Raman C.S., Rapoport T.A., Roll-Mecak A., Rosen M.K., Rudenko G., Schlessinger J., Schwartz T.U., Shamoo Y., Sondermann H., Tao Y.J., Tolia N.H., Tsodikov O.V., Westover K.D., Wu H., Foster I., Fraser J.S., Maia F.R.N.C., Gonen T., Kirchhausen T., Diederichs K., Crosas M., Sliz P.
Data publication with the structural biology data grid supports live analysis. Nature Communications7:, 2016. [Journal: Article] [CI: 104] [IF: 12,1]
DOI: 10.1038/ncomms10882 SCOPUS: 84960381776
Mitchell N.J., Sayers J., Kulkarni S.S., Clayton D., Goldys A.M., Ripoll-Rozada J., Barbosa Pereira P.J., Chan B., Radom L., Payne R.J.
Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry. Chem2(5):703-715, 2017. [Journal: Article] [CI: 56] [IF: 14,1]
DOI: 10.1016/j.chempr.2017.04.003 SCOPUS: 85019057964
Watson E.E., Liu X., Thompson R.E., Ripoll-Rozada J., Wu M., Alwis I., Gori A., Loh C.T., Parker B.L., Otting G., Jackson S., Pereira P.J.B., Payne R.J.
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics. ACS Central Science4(4):468-476, 2018. [Journal: Article] [CI: 32] [IF: 12,8]
DOI: 10.1021/acscentsci.7b00612 SCOPUS: 85045964682
Watson E.E., Ripoll-Rozada J., Lee A.C., Wu M.C.L., Franck C., Pasch T., Premdjee B., Sayers J., Pinto M.F., Martins P.M., Jackson S.P., Pereira P.J.B., Payne R.J.
Rapid assembly and profiling of an anticoagulant sulfoprotein library. Proceedings of the National Academy of Sciences of the United States of America116(28):13873-13878, 2019. [Journal: Article] [CI: 24] [IF: 9,4]
DOI: 10.1073/pnas.1905177116 SCOPUS: 85066962891