creating a
healthier future
Pedro J. B. Pereira
Group leader

Graduated in Biochemistry from the University of Porto in 1993. PhD student of Programa Gulbenkian de Doutoramento em Biologia e Medicina from 1993 to 1999. PhD fellow at the Max-Planck-Institut fuer Biochemie (Martinsried, Germany) from 1994 to 1999 (Supervisor: Prof. Dr. Dr. hc mult. Robert Huber). PhD in Biomedical Sciences (Biochemistry) from the University of Porto in 1999. FEBS Long-Term (1999-2000) and FCT (2000-2001) post-doctoral fellow at Institut de Biologia Molecular de Barcelona (IBMB-CSIC, Barcelona, Spain). Investigador Auxiliar (2002-2009) and Investigador Principal (2009-2022) at IBMC (Porto, Portugal). Investigador Principal (since 2023) at i3S (Porto, Portugal).

Selected Publications

José Barbosa Pereira P., Bergner A., Macedo-Ribeiro S., Huber R., Matschiner G., Fritz H., Sommerhoff C.P., Bode W.,
Human ß-tryptase is a ring-like tetramer with active sites facing a central pore. Nature392(6673):306-311, 1998. [Journal: Article] [CI: 287] [IF: 28,8]
DOI: 10.1038/32703 SCOPUS: 2642600031.

Pereira P.J.B., Lozanov V., Patthy A., Huber R., Bode W., Pongor S., Strobl S.,
Specific inhibition of insect a-amylases: Yellow meal worm a-amylase in complex with the Amaranth a-amylase inhibitor at 2.0 Å resolution. Structure7(9):1079-1088, 1999. [Journal: Article] [CI: 84] [IF: 7,3]
DOI: 10.1016/S0969-2126(99)80175-0 SCOPUS: 0006750734.

Pereira P.J.B., Macedo-Ribeiro S., Párraga A., Pérez-Luque R., Cunningham O., Darcy K., Mantle T.J., Coll M.,
Structure of human biliverdin IXß reductase, an early fetal bilirubin IXß producing enzyme. Nature Structural Biology8(3):215-220, 2001. [Journal: Article] [CI: 103] [IF: 11,7]
DOI: 10.1038/84948 SCOPUS: 0035119623.

Barbosa Pereira P.J., Segura-Martín S., Oliva B., Ferrer-Orta C., Avilés F.X., Coll M., Gomis-Rüth F.X., Vendrell J.,
Human procarboxypeptidase B: Three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). Journal of Molecular Biology321(3):537-547, 2002. [Journal: Article] [CI: 62] [IF: 5,4]
DOI: 10.1016/S0022-2836(02)00648-4 SCOPUS: 0036384505.

Rocha R., Pereira P.J.B., Santos M.A.S., Macedo-Ribeiro S.,
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen. Proceedings of the National Academy of Sciences of the United States of America108(34):14091-14096, 2011. [Journal: Article] [CI: 36] [IF: 9,7]
DOI: 10.1073/pnas.1102835108 SCOPUS: 80052182956.

Thompson R.E., Liu X., Alonso-García N., Pereira P.J.B., Jolliffe K.A., Payne R.J.,
Trifluoroethanethiol: An additive for efficient one-pot peptide ligation - Desulfurization chemistry. Journal of the American Chemical Society136(23):8161-8164, 2014. [Journal: Article] [CI: 107] [IF: 12,1]
DOI: 10.1021/ja502806r SCOPUS: 84902270939.

Meyer P.A., Socias S., Key J., Ransey E., Tjon E.C., Buschiazzo A., Lei M., Botka C., Withrow J., Neau D., Rajashankar K., Anderson K.S., Baxter R.H., Blacklow S.C., Boggon T.J., Bonvin A.M.J.J., Borek D., Brett T.J., Caflisch A., Chang C.I., Chazin W.J., Corbett K.D., Cosgrove M.S., Crosson S., Dhe-Paganon S., Di Cera E., Drennan C.L., Eck M.J., Eichman B.F., Fan Q.R., Ferré-D'Amaré A.R., Fromme J.C., Garcia K.C., Gaudet R., Gong P., Harrison S.C., Heldwein E.E., Jia Z., Keenan R.J., Kruse A.C., Kvansakul M., McLellan J.S., Modis Y., Nam Y., Otwinowski Z., Pai E.F., Pereira P.J.B., Petosa C., Raman C.S., Rapoport T.A., Roll-Mecak A., Rosen M.K., Rudenko G., Schlessinger J., Schwartz T.U., Shamoo Y., Sondermann H., Tao Y.J., Tolia N.H., Tsodikov O.V., Westover K.D., Wu H., Foster I., Fraser J.S., Maia F.R.N.C., Gonen T., Kirchhausen T., Diederichs K., Crosas M., Sliz P.,
Data publication with the structural biology data grid supports live analysis. Nature Communications7:, 2016. [Journal: Article] [CI: 96] [IF: 12,1]
DOI: 10.1038/ncomms10882 SCOPUS: 84960381776.

Mitchell N.J., Sayers J., Kulkarni S.S., Clayton D., Goldys A.M., Ripoll-Rozada J., Barbosa Pereira P.J., Chan B., Radom L., Payne R.J.,
Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry. Chem2(5):703-715, 2017. [Journal: Article] [CI: 54] [IF: 14,1]
DOI: 10.1016/j.chempr.2017.04.003 SCOPUS: 85019057964.

Watson E.E., Liu X., Thompson R.E., Ripoll-Rozada J., Wu M., Alwis I., Gori A., Loh C.T., Parker B.L., Otting G., Jackson S., Pereira P.J.B., Payne R.J.,
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics. ACS Central Science4(4):468-476, 2018. [Journal: Article] [CI: 30] [IF: 12,8]
DOI: 10.1021/acscentsci.7b00612 SCOPUS: 85045964682.

Watson E.E., Ripoll-Rozada J., Lee A.C., Wu M.C.L., Franck C., Pasch T., Premdjee B., Sayers J., Pinto M.F., Martins P.M., Jackson S.P., Pereira P.J.B., Payne R.J.,
Rapid assembly and profiling of an anticoagulant sulfoprotein library. Proceedings of the National Academy of Sciences of the United States of America116(28):13873-13878, 2019. [Journal: Article] [CI: 23] [IF: 9,4]
DOI: 10.1073/pnas.1905177116 SCOPUS: 85066962891.