Where Ideas grow
Pedro J. B. Pereira
Principal Researcher
Graduated in Biochemistry from the University of Porto in 1993. PhD student of Programa Gulbenkian de Doutoramento em Biologia e Medicina from 1993 to 1999. PhD fellow at the Max-Planck-Institut fuer Biochemie (Martinsried, Germany) from 1994 to 1999 (Supervisor: Prof. Dr. Dr. hc mult. Robert Huber). PhD in Biomedical Sciences (Biochemistry) from the University of Porto in 1999. FEBS Long-Term (1999-2000) and FCT (2000-2001) post-doctoral fellow at Institut de Biologia Molecular de Barcelona (IBMB-CSIC, Barcelona, Spain). Assistant Researcher (2002-2009) and Associate Researcher (since 2009) at IBMC (Porto, Portugal).

Selected Publications

José Barbosa Pereira P., Bergner A., Macedo-Ribeiro S., Huber R., Matschiner G., Fritz H., Sommerhoff C.P., Bode W.,
Human ß-tryptase is a ring-like tetramer with active sites facing a central pore. Nature392(6673):306-311, 1998. [Journal: Article] [CI: 270] [IF: 28,8]
DOI: 10.1038/32703 SCOPUS: 2642600031.


Pereira P.J.B., Macedo-Ribeiro S., Párraga A., Pérez-Luque R., Cunningham O., Darcy K., Mantle T.J., Coll M.,
Structure of human biliverdin IXß reductase, an early fetal bilirubin IXß producing enzyme. Nature Structural Biology8(3):215-220, 2001. [Journal: Article] [CI: 86] [IF: 11,7]
DOI: 10.1038/84948 SCOPUS: 0035119623.


Macedo-Ribeiro S., Almeida C., Calisto B.M., Friedrich T., Mentele R., Stürzebecher J., Fuentes-Prior P., Pereira P.J.B.,
Isolation, cloning and structural characterization of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick. PLoS ONE3(2):1-17, 2008. [Journal: Article] [CI: 82]
DOI: 10.1371/journal.pone.0001624 SCOPUS: 45849130590.


Rocha R., Pereira P.J.B., Santos M.A.S., Macedo-Ribeiro S.,
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen. Proceedings of the National Academy of Sciences of the United States of America108(34):14091-14096, 2011. [Journal: Article] [CI: 29] [IF: 9,7]
DOI: 10.1073/pnas.1102835108 SCOPUS: 80052182956.


Figueiredo A.C., De Sanctis D., Gutiérrez-Gallego R., Cereija T.B., Macedo-Ribeiro S., Fuentes-Prior P., Pereira P.J.B.,
Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proceedings of the National Academy of Sciences of the United States of America109(52):, 2012. [Journal: Article] [CI: 27] [IF: 9,7]
DOI: 10.1073/pnas.1211614109 SCOPUS: 84871839379.


Santos J.A., Alonso-Garciá N., Macedo-Ribeiro S., Barbosa Pereira P.J.,
The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium. Proceedings of the National Academy of Sciences of the United States of America111(22):, 2014. [Journal: Article] [CI: 25] [IF: 9,7]
DOI: 10.1073/pnas.1322728111 SCOPUS: 84901821729.


Meyer P.A., Socias S., Key J., Ransey E., Tjon E.C., Buschiazzo A., Lei M., Botka C., Withrow J., Neau D., Rajashankar K., Anderson K.S., Baxter R.H., Blacklow S.C., Boggon T.J., Bonvin A.M.J.J., Borek D., Brett T.J., Caflisch A., Chang C.I., Chazin W.J., Corbett K.D., Cosgrove M.S., Crosson S., Dhe-Paganon S., Di Cera E., Drennan C.L., Eck M.J., Eichman B.F., Fan Q.R., Ferré-D'Amaré A.R., Fromme J.C., Garcia K.C., Gaudet R., Gong P., Harrison S.C., Heldwein E.E., Jia Z., Keenan R.J., Kruse A.C., Kvansakul M., McLellan J.S., Modis Y., Nam Y., Otwinowski Z., Pai E.F., Pereira P.J.B., Petosa C., Raman C.S., Rapoport T.A., Roll-Mecak A., Rosen M.K., Rudenko G., Schlessinger J., Schwartz T.U., Shamoo Y., Sondermann H., Tao Y.J., Tolia N.H., Tsodikov O.V., Westover K.D., Wu H., Foster I., Fraser J.S., Maia F.R.N.C., Gonen T., Kirchhausen T., Diederichs K., Crosas M., Sliz P.,
Data publication with the structural biology data grid supports live analysis. Nature Communications7:, 2016. [Journal: Article] [CI: 71] [IF: 12,1]
DOI: 10.1038/ncomms10882 SCOPUS: 84960381776.


Thompson R.E., Liu X., Ripoll-Rozada J., Alonso-García N., Parker B.L., Pereira P.J.B., Payne R.J.,
Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. Nature Chemistry9(9):909-917, 2017. [Journal: Article] [CI: 37] [IF: 26,2]
DOI: 10.1038/NCHEM.2744 SCOPUS: 85028339870.


Manso J.A., Nunes-Costa D., Macedo-Ribeiro S., Empadinhas N., Pereira P.J.B.,
Molecular fingerprints for a novel enzyme family in actinobacteria with glucosamine kinase activity. mBio10(3):, 2019. [Journal: Article] [CI: 1] [IF: 6,8]
DOI: 10.1128/mBio.00239-19 SCOPUS: 85066245592.


Ripoll-Rozada J., Costa M., Manso J.A., Maranha A., Miranda V., Sequeira A., Rita Ventura M., Macedo-Ribeiro S., Pereira P.J.B., Empadinhas N.,
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. Proceedings of the National Academy of Sciences of the United States of America116(3):835-844, 2019. [Journal: Article] [IF: 9,4]
DOI: 10.1073/pnas.1813450116 SCOPUS: 85060031004.