Paula Soares

Histology and Electron Microscopy

Scientific Coordinator

Paula Soares, BSc, MSc, PhD, is Assistant Professor of Biopathology at the Medical Faculty of Porto and coordinates the Group of Cancer Biology at the IPATIMUP/Cancer signaling and Metabolism at I3S. She received her Biology degree in Science Faculty, University of Porto and MSc and PhD degrees at the Medical Faculty, University of Porto. Her main research interests include oncobiology of thyroid and other neuroendocrine tumors, mainly addressing the cellular and molecular biology of thyroid tumors. Her team identify BRAF and TERT promoter mutations in thyroid tumors and become one of the world?s most cited group in thyroid carcinogenesis. Besides participating or leading several national and international funded projects, the practical relevance of Paula?s work has allowed her to secure funding and collaborations from several major pharmaceutical companies. She has over 240 papers (including book chapters) in peer-reviewed journals, mainly addressing the cellular and molecular biology of thyroid tumors, with over 8.000 citations and an h-index of 45. She is also a member of numerous scientific committees and evaluation boards and serves on grant review committees and in journal editorial and review boards.

Selected Publications

Soares P., Trovisco V., Rocha A.S., Lima J., Castro P., Preto A., Máximo V., Botelho T., Seruca R., Sobrinho-Simões M.,

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene22(29):4578-4580, 2003. [Journal: Article] [CI: 579] [IF: 6,5]
DOI: 10.1038/sj.onc.1206706 SCOPUS: 0043170833.

Soares P., Sobrinho-Simões M.,

Cancer: Small papillary thyroid cancers-is BRAF of prognostic value?. Nature Reviews Endocrinology7(1):9-10, 2011. [Journal: Note] [CI: 17] [IF: 10]
DOI: 10.1038/nrendo.2010.213 SCOPUS: 78650410409.

Vinagre J., Almeida A., Pópulo H., Batista R., Lyra J., Pinto V., Coelho R., Celestino R., Prazeres H., Lima L., Melo M., Rocha A.G.D., Preto A., Castro P., Castro L., Pardal F., Lopes J.M., Santos L.L., Reis R.M., Cameselle-Teijeiro J., Sobrinho-Simões M., Lima J., Máximo V., Soares P.,

Frequency of TERT promoter mutations in human cancers. Nature Communications4:, 2013. [Journal: Article] [CI: 682] [IF: 10,7]
DOI: 10.1038/ncomms3185 SCOPUS: 84884524540.

Melo M., Da Rocha A.G., Vinagre J., Batista R., Peixoto J., Tavares C., Celestino R., Almeida A., Salgado C., Eloy C., Castro P., Prazeres H., Lima J., Amaro T., Lobo C., Martins M.J., Moura M., Cavaco B., Leite V., Cameselle-Teijeiro J.M., Carrilho F., Carvalheiro M., Máximo V., Sobrinho-Simões M., Soares P.,

TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism99(5):, 2014. [Journal: Article] [CI: 413] [IF: 6,2]
DOI: 10.1210/jc.2013-3734 SCOPUS: 84899908886.

Melo M., Da Rocha A.G., Vinagre J., Sobrinho-Simões M., Soares P.,

Coexistence of TERT promoter and BRAF mutations in papillary thyroid carcinoma: Added value in patient prognosis?. Journal of Clinical Oncology33(6):667-668, 2015. [Journal: Letter] [CI: 33] [IF: 21]
DOI: 10.1200/JCO.2014.59.4614 SCOPUS: 84923165572.

Melo M., Da Rocha A.G., Batista R., Vinagre J., Martins M.J., Costa G., Ribeiro C., Carrilho F., Leite V., Lobo C., Cameselle-Teijeiro J.M., Cavadas B., Pereira L., Sobrinho-Simoes M., Soares P.,

TERT, BRAF, and NRAS in primary thyroid cancer and metastatic disease. Journal of Clinical Endocrinology and Metabolism102(6):1898-1907, 2017. [Journal: Article] [CI: 92] [IF: 5,8]
DOI: 10.1210/jc.2016-2785 SCOPUS: 85020422515.

Vinagre J., Nabais J., Pinheiro J., Batista R., Oliveira R.C., Gonçalves A.P., Pestana A., Reis M., Mesquita B., Pinto V., Lyra J., Cipriano M.A., Ferreira M.G., Lopes J.M., Sobrinho-Simões M., Soares P.,

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes. Scientific Reports6:, 2016. [Journal: Article] [CI: 12] [IF: 4,3]
DOI: 10.1038/srep29714 SCOPUS: 84978645289.

Prazeres H., Torres J., Rodrigues F., Pinto M., Pastoriza M.C., Gomes D., Cameselle-Teijeiro J., Vidal A., Martins T.C., Sobrinho-Simões M., Soares P.,

Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells. Oncogene30(11):1302-1317, 2011. [Journal: Article] [CI: 64] [IF: 6,4]
DOI: 10.1038/onc.2010.512 SCOPUS: 79952775150.

Couto J.P., Daly L., Almeida A., Knauf J.A., Fagin J.A., Sobrinho-Simões M., Lima J., Máximo V., Soares P., Lyden D., Bromberg J.F.,

STAT3 negatively regulates thyroid tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America109(35):E2361-E2370, 2012. [Journal: Article] [CI: 110] [IF: 9,7]
DOI: 10.1073/pnas.1201232109 SCOPUS: 84871862427.

Boaventura P., Soares P., Pereira D., Teixeira-Gomes J., Sobrinho-Simões M.,

Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment. The Lancet Infectious Diseases11(3):163-164, 2011. [Journal: Letter] [CI: 14] [IF: 17,4]
DOI: 10.1016/S1473-3099(11)70047-0 SCOPUS: 79952026090.

Máximo V., Botelho T., Capela J., Soares P., Lima J., Taveira A., Amaro T., Barbosa A.P., Preto A., Harach H.R., Williams D., Sobrinho-Simões M.,

Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid. British Journal of Cancer92(10):1892-1898, 2005. [Journal: Article] [CI: 178] [IF: 4,1]
DOI: 10.1038/sj.bjc.6602547 SCOPUS: 20344366798.