creating a
healthier future
Cristina Barrias
Group leader

Cristina Barrias is Principal Investigator and Group Leader at Instituto de Investigação e Inovação em Saúde/ Instituto de Engenharia Biomédica (i3S/INEB, University of Porto), and invited Associate Professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS, University of Porto) and at Instituto Superior de Engenharia do Porto (ISEP, Polytechnic of Porto). Currently, she is also a member of the Board of Directors of INEB and a member of the Council of the European Society for Biomaterials (ESB). Her group at i3S ( focuses on (micro)tissue engineering for regenerative therapies and in vitro disease modeling. She has been working on the design of customized hydrogel 3D matrices and biofabrication tools to direct cellular self-organization into different types of micro-sized building blocks for bottom-up tissue engineering. These microsystems recapitulate complex tissue morphogenesis processes and are being used to investigate the dynamics of cell-cell and cell-matrix interactions in 3D, in pathophysiological contexts, and to decipher key biochemical and biomechanical regulators of cell response. Currently, this knowledge is being translated into the design of advanced 3D in vitro models and of improved therapies for tissue (re)vascularization.

Selected Publications

Feijão T., Neves M.I., Sousa A., Torres A.L., Bidarra S.J., Orge I.D., Carvalho D.T.O., Barrias C.C.,
Engineering injectable vascularized tissues from the bottom-up: Dynamics of in-gel extra-spheroid dermal tissue assembly. Biomaterials279:, 2021. [Journal: Article] [CI: 8] [IF: 15,3]
DOI: 10.1016/j.biomaterials.2021.121222 SCOPUS: 85118349708.

Carvalho D.T.O., Feijão T., Neves M.I., Da Silva R.M.P., Barrias C.C.,
Directed self-assembly of spheroids into modular vascular beds for engineering large tissue constructs. Biofabrication13(3):, 2021. [Journal: Article] [CI: 7] [IF: 11,1]
DOI: 10.1088/1758-5090/abc790 SCOPUS: 85105354294.

Teixeira F.C., Chaves S., Torres A.L., Barrias C.C., Bidarra S.J.,
Engineering a Vascularized 3D Hybrid System to Model Tumor-Stroma Interactions in Breast Cancer. Frontiers in Bioengineering and Biotechnology9:, 2021. [Journal: Article] [CI: 13] [IF: 6,1]
DOI: 10.3389/fbioe.2021.647031 SCOPUS: 85103053615.

Torres A.L., Bidarra S.J., Vasconcelos D.P., Barbosa J.N., Silva E.A., Nascimento D.S., Barrias C.C.,
Microvascular engineering: Dynamic changes in microgel-entrapped vascular cells correlates with higher vasculogenic/angiogenic potential. Biomaterials228:, 2020. [Journal: Article] [CI: 24] [IF: 12,5]
DOI: 10.1016/j.biomaterials.2019.119554 SCOPUS: 85074166551.

Neves S.C., Moroni L., Barrias C.C., Granja P.L.,
Leveling Up Hydrogels: Hybrid Systems in Tissue Engineering. Trends in Biotechnology38(3):292-315, 2020. [Journal: Review] [CI: 63] [IF: 19,5]
DOI: 10.1016/j.tibtech.2019.09.004 SCOPUS: 85075891574.

Campiglio C.E., Bidarra S.J., Draghi L., Barrias C.C.,
Bottom-up engineering of cell-laden hydrogel microfibrous patch for guided tissue regeneration. Materials Science and Engineering C108:, 2020. [Journal: Article] [CI: 17] [IF: 7,3]
DOI: 10.1016/j.msec.2019.110488 SCOPUS: 85075568685.

Araújo M., Bidarra S.J., Alves P.M., Valcarcel J., Vázquez J.A., Barrias C.C.,
Coumarin-grafted blue-emitting fluorescent alginate as a potentially valuable tool for biomedical applications. Journal of Materials Chemistry B8(4):813-825, 2020. [Journal: Article] [CI: 13] [IF: 6,3]
DOI: 10.1039/c9tb01402k SCOPUS: 85078683860.

Barros da Silva P., Coelho M., Bidarra S.J., Neves S.C., Barrias C.C.,
Reshaping in vitro Models of Breast Tissue: Integration of Stromal and Parenchymal Compartments in 3D Printed Hydrogels. Frontiers in Bioengineering and Biotechnology8:, 2020. [Journal: Article] [CI: 8] [IF: 5,9]
DOI: 10.3389/fbioe.2020.00494 SCOPUS: 85087017058.

Torres A.L., Bidarra S.J., Pinto M.T., Aguiar P.C., Silva E.A., Barrias C.C.,
Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis. Biomaterials154:34-47, 2018. [Journal: Article] [CI: 43] [IF: 10,3]
DOI: 10.1016/j.biomaterials.2017.10.051 SCOPUS: 85032820887.

Bidarra S.J., Oliveira P., Rocha S., Saraiva D.P., Oliveira C., Barrias C.C.,
A 3D in vitro model to explore the inter-conversion between epithelial and mesenchymal states during EMT and its reversion. Scientific Reports6:, 2016. [Journal: Article] [CI: 45] [IF: 4,3]
DOI: 10.1038/srep27072 SCOPUS: 84973343030.