Where Ideas grow
Eurico Morais de Sá
Group leader

Eurico Morais-de-Sá graduated at the University of Porto. Biochemist at heart, his first research experience was in X-ray protein Crystallography at IBMC, Porto (2003 to 2004). The GABBA PhD program made him trade the beauty of symmetric crystals for the challenge of asymmetric cells. This led him to the Gurdon Institute at the University of Cambridge (UK) to study cell polarity and body-axis specification for his PhD. In 2011, he obtained EMBO postdoctoral and Marie Curie Fellowships to come full circle, joining IBMC to understand how epithelial cells remodel their spatial organization to cope with the many challenges of cell division. He leads the group Epithelial Polarity & Cell Division since 2018.

Selected Publications

Ventura G., Moreira S., Barros-Carvalho A., Osswald M., Morais-de-Sá E.,
Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKC. Development147(15):, 2020. [Journal: Article] [IF: 5,6 (*)]
DOI: 10.1242/dev.186593 SCOPUS: 85089300645.

Moreira S., Osswald M., Ventura G., Gonçalves M., Sunkel C.E., Morais-de-Sá E.,
PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity. Cell Reports26(2):293-301.e7, 2019. [Journal: Article] [CI: 7] [IF: 8,1]
DOI: 10.1016/j.celrep.2018.12.060 SCOPUS: 85059397223.

Osswald M., Morais-de-Sá E.,
Dealing with apical–basal polarity and intercellular junctions: a multidimensional challenge for epithelial cell division. Current Opinion in Cell Biology60:75-83, 2019. [Journal: Review] [CI: 1] [IF: 8,2]
DOI: 10.1016/j.ceb.2019.04.006 SCOPUS: 85066055206.

Osswald M., Santos A.F., Morais-De-sá E.,
Light-induced protein clustering for optogenetic interference and protein interaction analysis in drosophila S2 cells. Biomolecules9(2):, 2019. [Journal: Article] [CI: 3] [IF: 4,1]
DOI: 10.3390/biom9020061 SCOPUS: 85061569009.

Carvalho C.A., Moreira S., Ventura G., Sunkel C.E., Morais-De-Sá E.,
Aurora a triggers Lgl cortical release during symmetric division to control planar spindle orientation. Current Biology25(1):53-60, 2015. [Journal: Article] [CI: 53] [IF: 9]
DOI: 10.1016/j.cub.2014.10.053 SCOPUS: 84920415073.

Morais-De-Sá E., Sunkel C.,
Adherens junctions determine the apical position of the midbody during follicular epithelial cell division. EMBO Reports14(8):696-703, 2013. [Journal: Article] [CI: 55] [IF: 7,9]
DOI: 10.1038/embor.2013.85 SCOPUS: 84881480225.

Morais-de-Sá E., Vega-Rioja A., Trovisco V., StJohnston D.,
Oskar is targeted for degradation by the sequential action of Par-1, GSK-3, and the SCF-Slimb ubiquitin ligase. Developmental Cell26(3):303-314, 2013. [Journal: Article] [CI: 12] [IF: 10,4]
DOI: 10.1016/j.devcel.2013.06.011 SCOPUS: 84881486520.

Morais-de-Sá E., Mirouse V., St Johnston D.,
aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells. Cell141(3):509-523, 2010. [Journal: Article] [CI: 184] [IF: 32,4]
DOI: 10.1016/j.cell.2010.02.040 SCOPUS: 77951911203.

Morais-de-Sá E., Pereira P.J.B., Saraiva M.J., Damas A.M.,
The crystal structure of transthyretin in complex with diethylstilbestrol: A promising template for the design of amyloid inhibitors. Journal of Biological Chemistry279(51):53483-53490, 2004. [Journal: Article] [CI: 46] [IF: 6,4]
DOI: 10.1074/jbc.M408053200 SCOPUS: 11144228259.