Where Ideas Grow
Paulo Aguiar
Group leader

Paulo Aguiar graduated in Physics (“Engª Física Tecnológica”) from Instituto Superior Técnico, U. of Lisbon, PT, and completed his PhD in Computational Neuroscience from the Institute for Adaptive and Neural Computation, U. of Edinburgh, UK, in 2006. Between 2006 and 2008 he worked as a postdoc at the Institute for Molecular and Cellular Biology (IBMC), PT, in the Neuroscience Research Unit. In 2008 he was awarded an “FCT Ciência” position (Assistant Researcher) and became Lecturer in Biomathematics and Computational Biology at the Center for Mathematics of U of Porto (CMUP), PT. In 2014 he joined the Institute for Biomedical Engineering (INEB), PT, as Assistant Researcher. To add to this multidisciplinary path, since 2014 he is also Affiliate Professor (“Professor Afiliado”) in Biophysics in the Faculty of Medicine of University of Porto. He has been responsible for MSc and PhD level courses in physics, mathematics, neurobiology and engineering in three Faculties at UP (Sciences, Medicine, Engineering).

Presently he is a Principal Investigator at i3S, holds an “IF Position” (Inv. FCT, DevG), and is leader of the research group “Neuroengineering and Computational Neuroscience”. His group follows a “neural computation” perspective and is focused on understanding how neural circuits are capable of transmitting, processing and storing information. The team combines expertise in neurobiology, electrophysiology and in vitro neuronal cultures with computational models and neuroengineering tools, to reveal and repair neural function. Paulo Aguiar is author in 60+ international peer-reviewed publications (including in Science, Nat. Cell Biology, J. Neuroscience, PNAS, J. Neural Eng., Medical Image Analysis; over 2100 citations and an h-factor of 21) and is the core developer of several scientific open-source software (collectively with +13,000 registered downloads). He has been already (co)PI/Task Leader in 11 national and international research projects, obtained in competitive calls.

Selected Publications

Mateus J.C., Lopes C.D.F., Cerquido M., Leitão L., Leitão D., Cardoso S., Ventura J., Aguiar P.,
Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis. Journal of Neural Engineering16(3):, 2019. [Journal: Article] [CI: 3] [IF: 4,1]
DOI: 10.1088/1741-2552/ab0b86 SCOPUS: 85065810756.

Heiney K., Mateus J.C., Lopes C.D.F., Neto E., Lamghari M., Aguiar P.,
µSpikeHunter: An advanced computational tool for the analysis of neuronal communication and action potential propagation in microfluidic platforms. Scientific Reports9(1):, 2019. [Journal: Article] [CI: 1] [IF: 4]
DOI: 10.1038/s41598-019-42148-3 SCOPUS: 85064068131.

Aresta G., Araújo T., Kwok S., Chennamsetty S.S., Safwan M., Alex V., Marami B., Prastawa M., Chan M., Donovan M., Fernandez G., Zeineh J., Kohl M., Walz C., Ludwig F., Braunewell S., Baust M., Vu Q.D., To M.N.N., Kim E., Kwak J.T., Galal S., Sanchez-Freire V., Brancati N., Frucci M., Riccio D., Wang Y., Sun L., Ma K., Fang J., Kone I., Boulmane L., Campilho A., Eloy C., Polónia A., Aguiar P.,
BACH: Grand challenge on breast cancer histology images. Medical Image Analysis56:122-139, 2019. [Journal: Article] [CI: 117] [IF: 11,1]
DOI: 10.1016/j.media.2019.05.010 SCOPUS: 85067343074.

Cerquido M., Proenca M.P., Dias C., Leitao D.C., Cardoso S., Freitas P.P., Aguiar P., Ventura J.,
Tailoring the cap's morphology of electrodeposited gold micro-mushrooms. Applied Surface Science445:512-518, 2018. [Journal: Article] [CI: 4] [IF: 5,2]
DOI: 10.1016/j.apsusc.2018.03.158 SCOPUS: 85044588454.

Mestre A.L.G., Cerquido M., Inácio P.M.C., Asgarifar S., Lourenço A.S., Cristiano M.L.S., Aguiar P., Medeiros M.C.R., Araújo I.M., Ventura J., Gomes H.L.,
Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations. Scientific Reports7(1):, 2017. [Journal: Article] [CI: 9] [IF: 4,1]
DOI: 10.1038/s41598-017-14697-y SCOPUS: 85032462728.

Mestre A.L.G., Inácio P.M.C., Elamine Y., Asgarifar S., Lourenço A.S., Cristiano M.L.S., Aguiar P., Medeiros M.C.R., Araújo I.M., Ventura J., Gomes H.L.,
Extracellular electrophysiological measurements of cooperative signals in astrocytes populations. Frontiers in Neural Circuits11:, 2017. [Journal: Article] [CI: 3] [IF: 3,1]
DOI: 10.3389/fncir.2017.00080 SCOPUS: 85032285952.

Neto E., Leitão L., Sousa D.M., Alves C.J., Alencastre I.S., Aguiar P., Lamghari M.,
Compartmentalized microfluidic platforms: The unrivaled breakthrough of in vitro tools for neurobiological research. Journal of Neuroscience36(46):11573-11584, 2016. [Journal: Article] [CI: 50] [IF: 6]
DOI: 10.1523/JNEUROSCI.1748-16.2016 SCOPUS: 84996552043.

Dias C., Guerra L.M., Ventura J., Aguiar P.,
Memristor-based Willshaw network: Capacity and robustness to noise in the presence of defects. Applied Physics Letters106(22):, 2015. [Journal: Article] [CI: 9] [IF: 3,1]
DOI: 10.1063/1.4922148 SCOPUS: 84930960301.

Neto E., Alves C.J., Sousa D.M., Alencastre I.S., Lourenço A.H., Leitão L., Ryu H.R., Jeon N.L., Fernandes R., Aguiar P., Almeida R.D., Lamghari M.,
Sensory neurons and osteoblasts: Close partners in a microfluidic platform. Integrative biology : quantitative biosciences from nano to macro6(6):586-595, 2014. [Journal: Article] [CI: 34] [IF: 3,8]
DOI: 10.1039/c4ib00035h SCOPUS: 84901624359.

Aguiar P., Sousa M., Szucs P.,
Versatile morphometric analysis and visualization of the three-dimensional structure of neurons. Neuroinformatics11(4):393-403, 2013. [Journal: Article] [CI: 16] [IF: 3,1]
DOI: 10.1007/s12021-013-9188-z SCOPUS: 84886291005.

Szucs P., Luz L.L., Pinho R., Aguiar P., Antal Z., Tiong S.Y.X., Todd A.J., Safronov B.V.,
Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord. Journal of Comparative Neurology521(12):2719-2741, 2013. [Journal: Article] [CI: 24] [IF: 3,5]
DOI: 10.1002/cne.23311 SCOPUS: 84879484866.

Pinto S., Krishna R., Dias C., Pimentel G., Oliveira G.N.P., Teixeira J.M., Aguiar P., Titus E., Gracio J., Ventura J., Araujo J.P.,
Resistive switching and activity-dependent modifications in Ni-doped graphene oxide thin films. Applied Physics Letters101(6):, 2012. [Journal: Article] [CI: 31] [IF: 3,8]
DOI: 10.1063/1.4742912 SCOPUS: 84865141673.

Aguiar P., Sousa M., Lima D.,
NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons. Journal of Neurophysiology104(2):1155-1166, 2010. [Journal: Article] [CI: 15] [IF: 3,1]
DOI: 10.1152/jn.00834.2009 SCOPUS: 77955972258.

Aguiar P., Mendonça L., Galhardo V.,
OpenControl: A free opensource software for video tracking and automated control of behavioral mazes. Journal of Neuroscience Methods166(1):66-72, 2007. [Journal: Article] [CI: 59] [IF: 1,9]
DOI: 10.1016/j.jneumeth.2007.06.020 SCOPUS: 34548491369.