creating a
healthier future
Margarida Saraiva
Group leader

Margarida Saraiva obtained a degree in Biochemistry in 1997, by Faculdade de Ciências da Universidade do Porto, Portugal. In 2003, Margarida Saraiva obtained a PhD in Pathology awarded by the University of Cambridge, UK. After 4 years (1999-2002) of research on Poxvirus Immune Evasion, in Antonio Alcami?s lab, at Cambridge University (UK), Margarida Saraiva moved to Anne O'Garra's lab, at the MRC-National Institute for Medical Research (London), where she investigated the molecular mechanisms that regulate the expression of Interleukin-10 by immune cells. In 2007, Margarida Saraiva returned to Portugal and joined the Life and Health Sciences Research Institute (ICVS) at Universidade do Minho, as a Ciência 2007 fellow. Since 2013, Margarida Saraiva is a FCT Associate Investigator. Since June 2015, Margarida Saraiva leads the Immune Regulation group at IBMC, aiming at investigating the mechanisms underlying the regulation of host-pathogen interactions. Margarida Saraiva served as President of the Portuguese Society for Immunology between 2018 and 2021.

Selected Publications

Sousa J., Cá B., Maceiras A.R., Simões-Costa L., Fonseca K.L., Fernandes A.I., Ramos A., Carvalho T., Barros L., Magalhães C., Chiner-Oms Á., Machado H., Veiga M.I., Singh A., Pereira R., Amorim A., Vieira J., Vieira C.P., Bhatt A., Rodrigues F., Rodrigues P.N.S., Gagneux S., Castro A.G., Guimarães J.T., Bastos H.N., Osório N.S., Comas I., Saraiva M.,
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production. Nature Communications11(1):, 2020. [Journal: Article] [CI: 45] [IF: 14,9]
DOI: 10.1038/s41467-020-15832-6 SCOPUS: 85083842157.

Fonseca K.L., Maceiras A.R., Matos R., Simoes-Costa L., Sousa J., Cá B., Barros L., Fernandes A.I., Mereiter S., Reis R., Gomes J., Tapia G., Rodríguez-Martínez P., Martín-Céspedes M., Vashakidze S., Gogishvili S., Nikolaishvili K., Appelberg R., Gärtner F., Rodrigues P.N.S., Vilaplana C., Reis C.A., Magalhães A., Saraiva M.,
Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils. Mucosal Immunology13(5):836-848, 2020. [Journal: Article] [CI: 15] [IF: 7,3]
DOI: 10.1038/s41385-020-0277-7 SCOPUS: 85082197621.

Moreira-Teixeira L., Stimpson P.J., Stavropoulos E., Hadebe S., Chakravarty P., Ioannou M., Aramburu I.V., Herbert E., Priestnall S.L., Suarez-Bonnet A., Sousa J., Fonseca K.L., Wang Q., Vashakidze S., Rodríguez-Martínez P., Vilaplana C., Saraiva M., Papayannopoulos V., O’Garra A.,
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis. Nature Communications11(1):, 2020. [Journal: Article] [CI: 80] [IF: 14,9]
DOI: 10.1038/s41467-020-19412-6 SCOPUS: 85094939183.

Moreira-Teixeira L., Sousa J., McNab F.W., Torrado E., Cardoso F., Machado H., Castro F., Cardoso V., Gaifem J., Wu X., Appelberg R., Castro A.G., O'Garra A., Saraiva M.,
Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ signaling. Journal of Immunology197(12):4714-4726, 2016. [Journal: Article] [CI: 69] [IF: 4,9]
DOI: 10.4049/jimmunol.1600584 SCOPUS: 85002328285.

Moreira-Teixeira L., Tabone O., Graham C.M., Singhania A., Stavropoulos E., Redford P.S., Chakravarty P., Priestnall S.L., Suarez-Bonnet A., Herbert E., Mayer-Barber K.D., Sher A., Fonseca K.L., Sousa J., Cá B., Verma R., Haldar P., Saraiva M., O’Garra A.,
Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology21(4):464-476, 2020. [Journal: Article] [CI: 53] [IF: 25,6]
DOI: 10.1038/s41590-020-0610-z SCOPUS: 85082258302.

Carmona J., Cruz A., Moreira-Teixeira L., Sousa C., Sousa J., Osorio N.S., Saraiva A.L., Svenson S., Kallenius G., Pedrosa J., Rodrigues F., Castro A.G., Saraiva M.,
Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. PLoS ONE8(6):, 2013. [Journal: Article] [CI: 65] [IF: 3,5]
DOI: 10.1371/journal.pone.0067277 SCOPUS: 84879468975.

Osório N.S., Rodrigues F., Gagneux S., Pedrosa J., Pinto-Carbó M., Castro A.G., Young D., Comas I., Saraiva M.,
Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure. Molecular Biology and Evolution30(6):1326-1336, 2013. [Journal: Article] [CI: 36] [IF: 14,3]
DOI: 10.1093/molbev/mst038 SCOPUS: 84877727980.

Saraiva M., O'Garra A.,
Biology and therapeutic potential of interleukin-10. Journal of Experimental Medicine217(1):, 2020. [Journal: Review] [CI: 372] [IF: 14,3]
DOI: 10.1084/jem_20190418 SCOPUS: 85076387681.

Maceiras A.R., Silvério D., Gonçalves R., Cardoso M.S., Saraiva M.,
Infection with hypervirulent Mycobacterium tuberculosis triggers emergency myelopoiesis but not trained immunity. Frontiers in Immunology14:, 2023. [Journal: Article] [IF: 7,3 (*)]
DOI: 10.3389/fimmu.2023.1211404 SCOPUS: 85163978125.

Cardoso A., Martins A.C., Maceiras A.R., Liu W., Castro I., Castro A.G., Bandeira A., Di Santo J.P., Cumano A., Li Y., Vieira P., Saraiva M.,
Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis. Cell Reports37(4):, 2021. [Journal: Article] [CI: 13] [IF: 10]
DOI: 10.1016/j.celrep.2021.109887 SCOPUS: 85119977049.