Where Ideas grow
Margarida Saraiva
Principal Researcher
Margarida Saraiva obtained a degree in Biochemistry in 1997, by Faculdade de Ciências da Universidade do Porto, Portugal. In 2003, Margarida Saraiva obtained a PhD in Pathology awarded by the University of Cambridge, UK. After 4 years (1999-2002) of research on Poxvirus Immune Evasion, in Antonio Alcami?s lab, at Cambridge University (UK), Margarida Saraiva moved to Anne O?Garra?s lab, at the MRC-National Institute for Medical Research (London), where she investigated the molecular mechanisms that regulate the expression of Interleukin-10 by immune cells. In 2007, Margarida Saraiva returned to Portugal and joined the Life and Health Sciences Research Institute (ICVS) at Universidade do Minho, as a Ciência 2007 fellow. Since 2013, Margarida Saraiva is a FCT Associate Investigator. Since June 2015, Margarida Saraiva leads the Immune Regulation group at IBMC, aiming at investigating the mechanisms underlying the regulation of host-pathogen interactions. Margarida Saraiva currently serves as board member of the Portuguese Society for Immunology

Selected Publications

Moreira-Teixeira L., Sousa J., McNab F.W., Torrado E., Cardoso F., Machado H., Castro F., Cardoso V., Gaifem J., Wu X., Appelberg R., Castro A.G., O'Garra A., Saraiva M.,
Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ signaling. Journal of Immunology197(12):4714-4726, 2016. [Journal: Article] [CI: 50] [IF: 4,9]
DOI: 10.4049/jimmunol.1600584 SCOPUS: 85002328285.


Bastos H.N., Osório N.S., Gagneux S., Comas I., Saraiva M.,
The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes. Frontiers in Immunology8(JAN):, 2018. [Journal: Review] [CI: 11] [IF: 4,7]
DOI: 10.3389/fimmu.2017.01948 SCOPUS: 85042558392.


Carmona J., Cruz A., Moreira-Teixeira L., Sousa C., Sousa J., Osorio N.S., Saraiva A.L., Svenson S., Kallenius G., Pedrosa J., Rodrigues F., Castro A.G., Saraiva M.,
Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. PLoS ONE8(6):, 2013. [Journal: Article] [CI: 51] [IF: 3,5]
DOI: 10.1371/journal.pone.0067277 SCOPUS: 84879468975.


Osório N.S., Rodrigues F., Gagneux S., Pedrosa J., Pinto-Carbó M., Castro A.G., Young D., Comas I., Saraiva M.,
Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure. Molecular Biology and Evolution30(6):1326-1336, 2013. [Journal: Article] [CI: 25] [IF: 14,3]
DOI: 10.1093/molbev/mst038 SCOPUS: 84877727980.