Mariana Osswald
Epithelial Polarity & Cell Division
Junior Researcher
Mariana Osswald studied bioengineering at the University of Porto. After completing her MSc degree in 2012, she worked on mitosis in the group of Claudio Sunkel at the IBMC in Porto. In 2015, she joined Eurico Morais de Sá’s group at IBMC/i3S for her PhD on cell polarity and cell division in epithelial tissues. She is currently conducting post-doctoral research at this group, aiming to understand mechanisms that ensure tissue architecture and integrity in proliferative epithelia.
Selected Publications
di Pietro F., Osswald M., De las Heras J.M., Cristo I., López-Gay J., Wang Z., Pelletier S., Gaugué I., Leroy A., Martin C., Morais-de-Sá E., Bellaïche Y.,
Osswald M., Barros-Carvalho A., Carmo A.M., Loyer N., Gracio P.C., Sunkel C.E., Homem C.C.F., Januschke J., Morais-de-Sá E.,
Osswald M., Morais-de-Sá E.,
Cunha-Silva S., Osswald M., Goemann J., Barbosa J., Santos L.M., Resende P., Bange T., Ferrás C., Sunkel C.E., Conde C.,
Moura M., Osswald M., Leça N., Barbosa J., Pereira A.J., Maiato H., Sunkel C.E., Conde C.,
Conde C., Osswald M., Barbosa J., Moutinho-Santos T., Pinheiro D., Guimarães S., Matos I., Maiato H., Sunkel C.E.,
Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division. Current Biology33(5):858-874.e7, 2023. [Journal: Article] [CI: 5] [IF: 9,2 (*)]
DOI: 10.1016/j.cub.2023.01.028 SCOPUS: 85149976826.
DOI: 10.1016/j.cub.2023.01.028 SCOPUS: 85149976826.
Osswald M., Barros-Carvalho A., Carmo A.M., Loyer N., Gracio P.C., Sunkel C.E., Homem C.C.F., Januschke J., Morais-de-Sá E.,
aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium. Current Biology32(20):4411-4427.e8, 2022. [Journal: Article] [CI: 8] [IF: 9,2]
DOI: 10.1016/j.cub.2022.08.063 SCOPUS: 85140317779.
DOI: 10.1016/j.cub.2022.08.063 SCOPUS: 85140317779.
Osswald M., Morais-de-Sá E.,
Dealing with apical–basal polarity and intercellular junctions: a multidimensional challenge for epithelial cell division. Current Opinion in Cell Biology60:75-83, 2019. [Journal: Review] [CI: 11] [IF: 8,2]
DOI: 10.1016/j.ceb.2019.04.006 SCOPUS: 85066055206.
DOI: 10.1016/j.ceb.2019.04.006 SCOPUS: 85066055206.
Cunha-Silva S., Osswald M., Goemann J., Barbosa J., Santos L.M., Resende P., Bange T., Ferrás C., Sunkel C.E., Conde C.,
Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology219(3):, 2020. [Journal: Article] [CI: 9] [IF: 10,5]
DOI: 10.1083/jcb.201906039 SCOPUS: 85077707501.
DOI: 10.1083/jcb.201906039 SCOPUS: 85077707501.
Moura M., Osswald M., Leça N., Barbosa J., Pereira A.J., Maiato H., Sunkel C.E., Conde C.,
Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing. eLife6:, 2017. [Journal: Article] [CI: 39] [IF: 7,6]
DOI: 10.7554/eLife.25366 SCOPUS: 85019849461.
DOI: 10.7554/eLife.25366 SCOPUS: 85019849461.
Conde C., Osswald M., Barbosa J., Moutinho-Santos T., Pinheiro D., Guimarães S., Matos I., Maiato H., Sunkel C.E.,
Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation. EMBO Journal32(12):1761-1777, 2013. [Journal: Article] [CI: 37] [IF: 10,7]
DOI: 10.1038/emboj.2013.109 SCOPUS: 84879459640.
DOI: 10.1038/emboj.2013.109 SCOPUS: 84879459640.