Where Ideas grow
Sandra Sousa
Group leader
Sandra Sousa obtained a PhD in Cellular Microbiology from the Université Paris VII-Denis Diderot in 2004. Her PhD studies supervised by Prof. Pascale Cossart at Institut Pasteur Paris, were focused on the mechanisms of Listeria monocytogenes entry into non-phagocytic cells. In 2005 she joined the Group of Molecular Microbiology at the IBMC (Porto, Portugal) as post-doctoral researcher. In 2008, she got a research position and developed her own research line within the Group of Molecular Microbiology, IBMC. Her current research aims to characterize the role of different components of the host cytoskeleton in the cellular infection process of bacterial pathogens.

Selected Publications

Costa A.C., Carvalho F., Cabanes D., Sousa S.,
Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination. Cellular and Molecular Life Sciences76(5):961-975, 2019. [Journal: Article] [CI: 2] [IF: 6,5]
DOI: 10.1007/s00018-018-2977-7 SCOPUS: 85057542589.


Brito C., Cabanes D., Sarmento Mesquita F., Sousa S.,
Mechanisms protecting host cells against bacterial pore-forming toxins. Cellular and Molecular Life Sciences76(7):1319-1339, 2019. [Journal: Review] [CI: 19] [IF: 6,5]
DOI: 10.1007/s00018-018-2992-8 SCOPUS: 85059153781.


Pinheiro J., Lisboa J., Pombinho R., Carvalho F., Carreaux A., Brito C., Pöntinen A., Korkeala H., Dos Santos N.M.S., Morais-Cabral J.H., Sousa S., Cabanes D.,
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. Nucleic Acids Research46(18):9338-9352, 2018. [Journal: Article] [CI: 10] [IF: 11,1]
DOI: 10.1093/nar/gky624 SCOPUS: 85054896319.


Cruz R., Pereira-Castro I., Almeida M.T., Moreira A., Cabanes D., Sousa S.,
Epithelial keratins modulate cMet expression and signaling and promote InlB-mediated Listeria monocytogenes infection of HeLa cells. Frontiers in Cellular and Infection Microbiology8(MAY):, 2018. [Journal: Article] [CI: 6] [IF: 3,5]
DOI: 10.3389/fcimb.2018.00146 SCOPUS: 85046878080.


Mesquita F.S., Brito C., Mazon Moya M.J., Pinheiro J.C., Mostowy S., Cabanes D., Sousa S.,
Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO Reports18(2):303-318, 2017. [Journal: Article] [CI: 9] [IF: 8,7]
DOI: 10.15252/embr.201642833 SCOPUS: 85007487818.


do Vale A., Cabanes D., Sousa S.,
Bacterial toxins as pathogen weapons against phagocytes. Frontiers in Microbiology7(FEB):, 2016. [Journal: Review] [CI: 32] [IF: 4,1]
DOI: 10.3389/fmicb.2016.00042 SCOPUS: 84962082244.


Almeida M.T., Mesquita F.S., Cruz R., Osório H., Custódio R., Brito C., Vingadassalom D., Martins M., Leong J.M., Holden D.W., Cabanes D., Sousa S.,
Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection. Journal of Biological Chemistry290(13):8383-8395, 2015. [Journal: Article] [CI: 11] [IF: 4,3]
DOI: 10.1074/jbc.M114.591313 SCOPUS: 84925760833.


Leitão E., Costa A.C., Brito C., Costa L., Pombinho R., Cabanes D., Sousa S.,
Listeria monocytogenes induces host DNA damage and delays the host cell cycle to promote infection. Cell Cycle13(6):928-940, 2014. [Journal: Article] [CI: 21] [IF: 4,6]
DOI: 10.4161/cc.27780 SCOPUS: 84897994129.


Martins M., Custodio R., Camejo A., Almeida M.T., Cabanes D., Sousa S.,
Listeria monocytogenes triggers the cell surface expression of Gp96 protein and interacts with its N terminus to support cellular infection. Journal of Biological Chemistry287(51):43083-43093, 2012. [Journal: Article] [CI: 19] [IF: 4,7]
DOI: 10.1074/jbc.M112.422568 SCOPUS: 84871163192.