Where Ideas grow

Stem Cells in Regenerative Biology and Repair

Depth colour-coded stack of a E14.5 foetal liver's thick section staining haematopoietic cell

Team Coordinator


Selected Publications

Sampaio-Pinto V., Rodrigues S.C., Laundos T.L., Silva E.D., Vasques-Nóvoa F., Silva A.C., Cerqueira R.J., Resende T.P., Pianca N., Leite-Moreira A., D'Uva G., Thorsteinsdóttir S., Pinto-do-Ó P., Nascimento D.S.,
Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularization and Functional Recovery Despite Local Fibrosis. Stem Cell Reports10(3):860-874, 2018. [Journal: Article] [CI: 8] [IF: 5,5]
DOI: 10.1016/j.stemcr.2018.01.042 SCOPUS: 85042586130. .

Garlíková Z., Silva A.C., Rabata A., Potšil D., Ihnatová I., Dumková J., Koledová Z., Zdráhal Z., Vinarský V., Hampl A., Pinto-Do-Ó P., Nascimento D.S.,
Generation of a close-to-native in vitro system to study lung cells-extracellular matrix crosstalk. Tissue Engineering - Part C: Methods24(1):1-13, 2018. [Journal: Article] [CI: 2] [IF: 2,6]
DOI: 10.1089/ten.tec.2017.0283 SCOPUS: 85040451819. .

Ribeiro-Rodrigues T.M., Laundos T.L., Pereira-Carvalho R., Batista-Almeida D., Pereira R., Coelho-Santos V., Silva A.P., Fernandes R., Zuzarte M., Enguita F.J., Costa M.C., Pinto-Do-O P., Pinto M.T., Gouveia P., Ferreira L., Mason J.C., Pereira P., Kwak B.R., Nascimento D.S., Girao H.,
Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Cardiovascular Research113(11):1338-1350, 2017. [Journal: Article] [CI: 44] [IF: 6,3]
DOI: 10.1093/cvr/cvx118 SCOPUS: 85030638942. .

Ragni C.V., Diguet N., Le Garrec J.F., Novotova M., Resende T.P., Pop S., Charon N., Guillemot L., Kitasato L., Badouel C., Dufour A., Olivo-Marin J.C., Trouvé A., McNeill H., Meilhac S.M.,
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nature Communications8:, 2017. [Journal: Article] [CI: 31] [IF: 12,4]
DOI: 10.1038/ncomms14582 SCOPUS: 85014245581. .

Freire A.G., Waghray A., Soares-da-Silva F., Resende T.P., Lee D.F., Pereira C.F., Nascimento D.S., Lemischka I.R., Pinto-do-Ó P.,
Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. Stem Cell Reports9(1):136-148, 2017. [Journal: Article] [CI: 2] [IF: 6,5]
DOI: 10.1016/j.stemcr.2017.05.025 SCOPUS: 85021126795. .

Pinto M.L., Rios E., Silva A.C., Neves S.C., Caires H.R., Pinto A.T., Durães C., Carvalho F.A., Cardoso A.P., Santos N.C., Barrias C.C., Nascimento D.S., Pinto-do-Ó P., Barbosa M.A., Carneiro F., Oliveira M.J.,
Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18. Biomaterials124:211-224, 2017. [Journal: Article] [CI: 37] [IF: 8,8]
DOI: 10.1016/j.biomaterials.2017.02.004 SCOPUS: 85013069713. .

Silva A.C., Rodrigues S.C., Caldeira J., Nunes A.M., Sampaio-Pinto V., Resende T.P., Oliveira M.J., Barbosa M.A., Thorsteinsdóttir S., Nascimento D.S., Pinto-do-Ó P.,
Three-dimensional scaffolds of fetal decellularized hearts exhibit enhanced potential to support cardiac cells in comparison to the adult. Biomaterials104:52-64, 2016. [Journal: Article] [CI: 15] [IF: 8,4]
DOI: 10.1016/j.biomaterials.2016.06.062 SCOPUS: 84978822623. .

Ferroni M., Giusti S., Nascimento D., Silva A., Boschetti F., Ahluwalia A.,
Modeling the fluid-dynamics and oxygen consumption in a porous scaffold stimulated by cyclic squeeze pressure. Medical Engineering and Physics38(8):725-732, 2016. [Journal: Article] [CI: 8] [IF: 1,8]
DOI: 10.1016/j.medengphy.2016.04.016 SCOPUS: 84966781440. .

Valente M., Araújo A., Esteves T., Laundos T.L., Freire A.G., Quelhas P., Pinto-do-Ó P., Nascimento D.S.,
Optimized Heart Sampling and Systematic Evaluation of Cardiac Therapies in Mouse Models of Ischemic Injury: Assessment of Cardiac Remodeling and Semi-Automated Quantification of Myocardial Infarct Size. Current protocols in mouse biology5(4):359-391, 2015. [Journal: Article] [CI: 2]
DOI: 10.1002/9780470942390.mo140293 SCOPUS: 84988000549. .

Santos J.M., Camões S.P., Filipe E., Cipriano M., Barcia R.N., Filipe M., Teixeira M., Simões S., Gaspar M., Mosqueira D., Nascimento D.S., Pinto-Do-Ó P., Cruz P., Cruz H., Castro M., Miranda J.P.,
Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing. Stem Cell Research and Therapy6(1):, 2015. [Journal: Article] [CI: 55] [IF: 4,5]
DOI: 10.1186/s13287-015-0082-5 SCOPUS: 84930684508. .

Mosqueira D., Pagliari S., Uto K., Ebara M., Romanazzo S., Escobedo-Lucea C., Nakanishi J., Taniguchi A., Franzese O., Di Nardo P., Goumans M.J., Traversa E., Pinto-Do-Ó P., Aoyagi T., Forte G.,
Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure. ACS Nano8(3):2033-2047, 2014. [Journal: Article] [CI: 69] [IF: 12,9]
DOI: 10.1021/nn4058984 SCOPUS: 84896911335. .

Nascimento D.S., Mosqueira D., Sousa L.M., Teixeira M., Filipe M., Resende T.P., Araújo A.F., Valente M., Almeida J., Martins J.P., Santos J.M., Bárcia R.N., Cruz P., Cruz H., Pinto-Do-Ó P.,
Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms. Stem Cell Research and Therapy5(1):, 2014. [Journal: Article] [CI: 77] [IF: 3,4]
DOI: 10.1186/scrt394 SCOPUS: 84896713037. .

Valente M., Nascimento D.S., Cumano A., Pinto-Do-Ó P.,
Sca-1+cardiac progenitor cells and heart-making: A critical synopsis. Stem Cells and Development23(19):2263-2273, 2014. [Journal: Review] [CI: 31] [IF: 3,7]
DOI: 10.1089/scd.2014.0197 SCOPUS: 84907432293. .

Freire A.G., Nascimento D.S., Forte G., Valente M., Resende T.P., Pagliari S., Abreu C., Carvalho I., Nardo P.D., Pinto-Do-Ó P.,
Stable phenotype and function of immortalized Lin-Sca-1 + cardiac progenitor cells in long-term culture: A step closer to standardization. Stem Cells and Development23(9):1012-1026, 2014. [Journal: Article] [CI: 9] [IF: 3,7]
DOI: 10.1089/scd.2013.0305 SCOPUS: 84896901797. .

Miranda C.O., Teixeira C.A., Sousa V.F., Santos T.E., Liz M.A., Marques A.M., Pinto-do-Ó P., Sousa M.M.,
Primary bone marrow mesenchymal stromal cells rescue the axonal phenotype of twitcher mice. Cell Transplantation23(2):239-252, 2014. [Journal: Article] [CI: 7] [IF: 3,1]
DOI: 10.3727/096368913X669752 SCOPUS: 84893339069. .

Freire A.G., Resende T.P., Pinto-Do-Ó P.,
Building and repairing the heart: What can we learn from embryonic development?. BioMed Research International2014:, 2014. [Journal: Review] [CI: 6] [IF: 1,6]
DOI: 10.1155/2014/679168 SCOPUS: 84900022530. .

Pagliari S., Romanazzo S., Mosqueira D., Pinto-Do-Ó P., Aoyagi T., Forte G.,
Adult stem cells and biocompatible scaffolds as smart drug delivery tools for cardiac tissue repair. Current Medicinal Chemistry20(28):3429-3447, 2013. [Journal: Review] [CI: 7] [IF: 3,7]
DOI: 10.2174/09298673113209990032 SCOPUS: 84883267656. .

Esteves T., Valente M., Nascimento D.S., Pinto-Do-Ó P., Quelhas P.,
Automatic myocardial infarction size extraction in an experimental murine model using an anatomical model. Proceedings - International Symposium on Biomedical Imaging:310-313, 2012. [Conference Proceeding: Conference Paper] [CI: 1]
DOI: 10.1109/ISBI.2012.6235546 SCOPUS: 84864832695. .

Nascimento D.S., Valente M., Esteves T., de Fátima de Pina M., Guedes J.G., Freire A., Quelhas P., Pinto-do-Ó P.,
MIQuant - semi-automation of infarct size assessment in models of cardiac ischemic injury. PLoS ONE6(9):, 2011. [Journal: Article] [CI: 23] [IF: 4,1]
DOI: 10.1371/journal.pone.0025045 SCOPUS: 80053583980. .

Miranda C.O., Teixeira C.A., Liz M.A., Sousa V.F., Franquinho F., Forte G., Di Nardo P., Pinto-Do-Ó P., Sousa M.M.,
Systemic delivery of bone marrow-derived mesenchymal stromal cells diminishes neuropathology in a mouse model of Krabbe's disease. Stem Cells29(11):1738-1751, 2011. [Journal: Article] [CI: 17] [IF: 7,8]
DOI: 10.1002/stem.724 SCOPUS: 80054957115. .

Real C., Remédio L., Caiado F., Igreja C., Borges C., Trindade A., Pinto-do-Ó P., Yagita H., Duarte A., Dias S.,
Bone marrow-derived endothelial progenitors expressing delta-like 4 (Dll4) regulate tumor angiogenesis. PLoS ONE6(4):, 2011. [Journal: Article] [CI: 15] [IF: 4,1]
DOI: 10.1371/journal.pone.0018323 SCOPUS: 79953685607. .

Esteves T., Valente M., Nascimento D.S., Pinto-Do-Ó P., Quelhas P.,
Automatic and semi-automatic analysis of the extension of myocardial infarction in an experimental murine model. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)6669 LNCS:151-158, 2011. [Book Series: Conference Paper] [CI: 1] [IF: ,3 (*)]
DOI: 10.1007/978-3-642-21257-4_19 SCOPUS: 79959927807. .

Cachaço A.S., Carvalho T., Santos A.C., Igreja C., Fragoso R., Rio C.O., Ferreira M., Serpa J., Correia S., Pinto-do-Ó P., Dias S.,
TNF-a regulates the effects of irradiation in the mouse bone marrow microenvironment. PLoS ONE5(2):, 2010. [Journal: Article] [CI: 28] [IF: 4,4]
DOI: 10.1371/journal.pone.0008980 SCOPUS: 77749280454. .